Humoral immune responses in CD40 ligand-deficient mice

doi:10.1084/jem.180.5.1889

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Humoral immune responses in CD40 ligand-deficient mice

BR Renshaw, WC Fanslow 3rd, RJ Armitage, KA Campbell, D Liggitt, B Wright, BL Davison and CR Maliszewski
Department of Molecular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101.

Individuals with X-linked hyper-IgM syndrome fail to express functional CD40 ligand (CD40L) and, as a consequence, are incapable of mounting protective antibody responses to opportunistic bacterial infections. To address the role of CD40L in humoral immunity, we created, through homologous recombination, mice deficient in CD40L expression. These mice exhibited no gross developmental deficiencies or health abnormalities and contained normal percentages of B and T cell subpopulations. CD40L-deficient mice did display selective deficiencies in humoral immunity; basal serum isotype levels were significantly lower than observed in normal mice, and IgE was undetectable. Furthermore, the CD40L-deficient mice failed to mount secondary antigen- specific responses to immunization with a thymus-dependent antigen, trinitrophenol-conjugated keyhole limpet hemocyanin (TNP-KLH). By contrast, the CD40L-deficient mice produced antigen-specific antibody of all isotypes except IgE in response to the thymus-independent antigen, DNP-Ficoll. These results underscore the requirement of CD40L for T cell-dependent antibody responses. Moreover, Ig class switching to isotypes other than IgE can occur in vivo in the absence of CD40L, supporting the notion that alternative B cell signaling pathways regulate responses to thymus-independent antigens.
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Yasui, T., Muraoka, M., Takaoka-Shichijo, Y., Ishida, I., Takegahara, N., Uchida, J., Kumanogoh, A., Suematsu, S., Suzuki, M., Kikutani, H. (2002). Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Int Immunol 14: 319-329 [Abstract] [Full Text]
Martinez-Barnetche, J., Madrid-Marina, V., Flavell, R. A., Moreno, J. (2002). Does CD40 Ligation Induce B Cell Negative Selection?. J. Immunol. 168: 1042-1049 [Abstract] [Full Text]
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Nakae, S., Asano, M., Horai, R., Sakaguchi, N., Iwakura, Y. (2001). IL-1 Enhances T Cell-Dependent Antibody Production Through Induction of CD40 Ligand and OX40 on T Cells. J. Immunol. 167: 90-97 [Abstract] [Full Text]
Kang, H. S., Lee, M. J., Song, H., Han, S. H., Kim, Y. M., Im, J. Y., Choi, I. (2001). Molecular Identification of IgE-Dependent Histamine-Releasing Factor as a B Cell Growth Factor. J. Immunol. 166: 6545-6554 [Abstract] [Full Text]
Rossi, G., Sarkar, J., Scandella, D. (2001). Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A. Blood 97: 2750-2757 [Abstract] [Full Text]
Green, K. A., Noelle, R. J., Durell, B. G., Green, W. R. (2001). Characterization of the CD154-Positive and CD40-Positive Cellular Subsets Required for Pathogenesis in Retrovirus-Induced Murine Immunodeficiency. J. Virol. 75: 3581-3589 [Abstract] [Full Text]
Erickson, L. D., Foy, T. M., Waldschmidt, T. J. (2001). Murine B1 B Cells Require IL-5 for Optimal T Cell-Dependent Activation. J. Immunol. 166: 1531-1539 [Abstract] [Full Text]
Weller, S., Faili, A., Garcia, C., Braun, M. C., Le Deist, F., de Saint Basile, G., Hermine, O., Fischer, A., Reynaud, C.-A., Weill, J.-C. (2001). CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc. Natl. Acad. Sci. USA 98: 1166-1170 [Abstract] [Full Text]
Kumanogoh, A., Wang, X., Lee, I., Watanabe, C., Kamanaka, M., Shi, W., Yoshida, K., Sato, T., Habu, S., Itoh, M., Sakaguchi, N., Sakaguchi, S., Kikutani, H. (2001). Increased T Cell Autoreactivity in the Absence of CD40-CD40 Ligand Interactions: A Role of CD40 in Regulatory T Cell Development. J. Immunol. 166: 353-360 [Abstract] [Full Text]
Gartner, F., Alt, F. W., Monroe, R. J., Seidl, K. J. (2000). Antigen-independent Appearance of Recombination Activating Gene (RAG)-positive Bone Marrow B Cells in the Spleens of Immunized Mice. JEM 192: 1745-1754 [Abstract] [Full Text]
Lentz, V. M., Manser, T. (2000). Self-limiting systemic autoimmune disease during reconstitution of T cell-deficient mice with syngeneic T cells: support for a multifaceted role of T cells in the maintenance of peripheral B cell tolerance. Int Immunol 12: 1483-1497 [Abstract] [Full Text]
Brezinschek, H.-P., Dorner, T., Monson, N. L., Brezinschek, R. I., Lipsky, P. E. (2000). The influence of CD40-CD154 interactions on the expressed human VH repertoire: analysis of VH genes expressed by individual B cells of a patient with X-linked hyper-IgM syndrome. Int Immunol 12: 767-775 [Abstract] [Full Text]
Szomolanyi-Tsuda, E., Brien, J. D., Dorgan, J. E., Welsh, R. M., Garcea, R. L. (2000). The Role of CD40-CD154 Interaction in Antiviral T Cell-Independent IgG Responses. J. Immunol. 164: 5877-5882 [Abstract] [Full Text]
Li, L., Zhang, X., Kovacic, S., Long, A. J., Bourque, K., Wood, C. R., Choi, Y. S. (2000). Identification of a Human Follicular Dendritic Cell Molecule That Stimulates Germinal Center B Cell Growth. JEM 191: 1077-1084 [Abstract] [Full Text]
Lee, R. S., Yamada, K., Womer, K. L., Pillsbury, E. P., Allison, K. S., Marolewski, A. E., Geng, D., Thall, A. D., Arn, J. S., Sachs, D. H., Sayegh, M. H., Madsen, J. C. (2000). Blockade of CD28-B7, But Not CD40-CD154, Prevents Costimulation of Allogeneic Porcine and Xenogeneic Human Anti-Porcine T Cell Responses. J. Immunol. 164: 3434-3444 [Abstract] [Full Text]
Boyd, Y., Blair, H. J., Cunliffe, P., Masson, W. K., Reed, V. (2000). A Phenotype Map of the Mouse X Chromosome: Models for Human X-linked Disease. Genome Res 10: 277-292 [Abstract] [Full Text]
Kennedy, M. K., Glaccum, M., Brown, S. N., Butz, E. A., Viney, J. L., Embers, M., Matsuki, N., Charrier, K., Sedger, L., Willis, C. R., Brasel, K., Morrissey, P. J., Stocking, K., Schuh, J. C. L., Joyce, S., Peschon, J. J. (2000). Reversible Defects in Natural Killer and Memory CD8 T Cell Lineages in Interleukin 15-deficient Mice. JEM 191: 771-780 [Abstract] [Full Text]
Hwang, Y.-i., Nahm, M. H., Briles, D. E., Thomas, D., Purkerson, J. M. (2000). Acquired, but Not Innate, Immune Responses to Streptococcus pneumoniae Are Compromised by Neutralization of CD40L. Infect. Immun. 68: 511-517 [Abstract] [Full Text]
Denepoux, S., Fournier, N., Peronne, C., Banchereau, J., Lebecque, S. (2000). T Cells Can Induce Somatic Mutation in B Cell Receptor-Engaged BL2 Burkitt's Lymphoma Cells Independently of CD40-CD40 Ligand Interactions. J. Immunol. 164: 1306-1313 [Abstract] [Full Text]
Karrer, U., Lopez-Macias, C., Oxenius, A., Odermatt, B., Bachmann, M. F., Kalinke, U., Bluethmann, H., Hengartner, H., Zinkernagel, R. M. (2000). Antiviral B Cell Memory in the Absence of Mature Follicular Dendritic Cell Networks and Classical Germinal Centers in TNFR1-/- Mice. J. Immunol. 164: 768-778 [Abstract] [Full Text]
Choe, J., Li, L., Zhang, X., Gregory, C. D., Choi, Y. S. (2000). Distinct Role of Follicular Dendritic Cells and T Cells in the Proliferation, Differentiation, and Apoptosis of a Centroblast Cell Line, L3055. J. Immunol. 164: 56-63 [Abstract] [Full Text]
Chirmule, N., Tazelaar, J., Wilson, J. M. (2000). Th2-Dependent B Cell Responses in the Absence of CD40-CD40 Ligand Interactions. J. Immunol. 164: 248-255 [Abstract] [Full Text]
Golovkina, T. V., Shlomchik, M., Hannum, L., Chervonsky, A. (1999). Organogenic Role of B Lymphocytes in Mucosal Immunity. Science 286: 1965-1968 [Abstract] [Full Text]
Guttormsen, H.-K., Sharpe, A. H., Chandraker, A. K., Brigtsen, A. K., Sayegh, M. H., Kasper, D. L. (1999). Cognate Stimulatory B-Cell-T-Cell Interactions Are Critical for T-Cell Help Recruited by Glycoconjugate Vaccines. Infect. Immun. 67: 6375-6384 [Abstract] [Full Text]
Lefrancois, L., Olson, S., Masopust, D. (1999). A Critical Role for CD40-CD40 Ligand Interactions in Amplification of the Mucosal CD8 T Cell Response. JEM 190: 1275-1284 [Abstract] [Full Text]
Brooks, J. W., Hamilton-Easton, A. M., Christensen, J. P., Cardin, R. D., Hardy, C. L., Doherty, P. C. (1999). Requirement for CD40 Ligand, CD4+ T Cells, and B Cells in an Infectious Mononucleosis-Like Syndrome. J. Virol. 73: 9650-9654 [Abstract] [Full Text]
Tan, J. T., Whitmire, J. K., Ahmed, R., Pearson, T. C., Larsen, C. P. (1999). 4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses. J. Immunol. 163: 4859-4868 [Abstract] [Full Text]
Grammer, A. C., McFarland, R. D., Heaney, J., Darnell, B. F., Lipsky, P. E. (1999). Expression, Regulation, and Function of B Cell-Expressed CD154 in Germinal Centers. J. Immunol. 163: 4150-4159 [Abstract] [Full Text]
Uchida, J., Yasui, T., Takaoka-Shichijo, Y., Muraoka, M., Kulwichit, W., Raab-Traub, N., Kikutani, H. (1999). Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses. Science 286: 300-303 [Abstract] [Full Text]
Marriott, I., Thomas, E. K., Bost, K. L. (1999). CD40-CD40 Ligand Interactions Augment Survival of Normal Mice, but Not CD40 Ligand Knockout Mice, Challenged Orally with Salmonella dublin. Infect. Immun. 67: 5253-5257 [Abstract] [Full Text]
Whitmire, J. K., Flavell, R. A., Grewal, I. S., Larsen, C. P., Pearson, T. C., Ahmed, R. (1999). CD40-CD40 Ligand Costimulation Is Required for Generating Antiviral CD4 T Cell Responses But Is Dispensable for CD8 T Cell Responses. J. Immunol. 163: 3194-3201 [Abstract] [Full Text]
Shepherd, D. M., Kerkvliet, N. I. (1999). Disruption of CD154:CD40 Blocks Generation of Allograft Immunity Without Affecting APC Activation. J. Immunol. 163: 2470-2477 [Abstract] [Full Text]
Murakami, K., Ma, W., Fuleihan, R., Pober, J. S. (1999). Human Endothelial Cells Augment Early CD40 Ligand Expression in Activated CD4+ T Cells Through LFA-3-Mediated Stabilization of mRNA. J. Immunol. 163: 2667-2673 [Abstract] [Full Text]
Borges, L., Miller, R. E., Jones, J., Ariail, K., Whitmore, J., Fanslow, W., Lynch, D. H. (1999). Synergistic Action of fms-Like Tyrosine Kinase 3 Ligand and CD40 Ligand in the Induction of Dendritic Cells and Generation of Antitumor Immunity In Vivo. J. Immunol. 163: 1289-1297 [Abstract] [Full Text]
Wu, Z.-Q., Vos, Q., Shen, Y., Lees, A., Wilson, S. R., Briles, D. E., Gause, W. C., Mond, J. J., Snapper, C. M. (1999). In Vivo Polysaccharide-Specific IgG Isotype Responses to Intact Streptococcus pneumoniae Are T Cell Dependent and Require CD40- and B7-Ligand Interactions. J. Immunol. 163: 659-667 [Abstract] [Full Text]
Hayashi, T., Rao, S. P., Meylan, P. R., Kornbluth, R. S., Catanzaro, A. (1999). Role of CD40 Ligand in Mycobacterium avium Infection. Infect. Immun. 67: 3558-3565 [Abstract] [Full Text]
Martin-Fontecha, A., Assarsson, E., Carbone, E., Karre, K., Ljunggren, H.-G. (1999). Triggering of Murine NK Cells by CD40 and CD86 (B7-2). J. Immunol. 162: 5910-5916 [Abstract] [Full Text]
Sutherland, C. L., Krebs, D. L., Gold, M. R. (1999). An 11-Amino Acid Sequence in the Cytoplasmic Domain of CD40 Is Sufficient for Activation of c-Jun N-Terminal Kinase, Activation of MAPKAP Kinase-2, Phosphorylation of I{kappa}B{alpha}, and Protection of WEHI-231 Cells from Anti-IgM-Induced Growth Arrest. J. Immunol. 162: 4720-4730 [Abstract] [Full Text]
Kweon, M.-N., Fujihashi, K., Wakatsuki, Y., Koga, T., Yamamoto, M., McGhee, J. R., Kiyono, H. (1999). Mucosally Induced Systemic T Cell Unresponsiveness to Ovalbumin Requires CD40 Ligand-CD40 Interactions. J. Immunol. 162: 1904-1909 [Abstract] [Full Text]
Matsumoto, M., Ra, C., Kawamoto, K., Sato, H., Itakura, A., Sawada, J., Ushio, H., Suto, H., Mitsuishi, K., Hikasa, Y., Matsuda, H. (1999). IgE Hyperproduction Through Enhanced Tyrosine Phosphorylation of Janus Kinase 3 in NC/Nga Mice, a Model for Human Atopic Dermatitis. J. Immunol. 162: 1056-1063 [Abstract] [Full Text]
Lai, Y. H., Mosmann, T. R. (1999). Mouse IL-13 Enhances Antibody Production In Vivo and Acts Directly on B Cells In Vitro to Increase Survival and Hence Antibody Production. J. Immunol. 162: 78-87 [Abstract] [Full Text]
Gramaglia, I., Weinberg, A. D., Lemon, M., Croft, M. (1998). Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses. J. Immunol. 161: 6510-6517 [Abstract] [Full Text]
Pulendran, B., Smith, J.L., Jenkins, M., Schoenborn, M., Maraskovsky, E., Maliszewski, C.R. (1998). Prevention of Peripheral Tolerance by a Dendritic Cell Growth Factor: Flt3 Ligand as an Adjuvant. JEM 188: 2075-2082 [Abstract] [Full Text]
Niimi, M., Pearson, T. C., Larsen, C. P., Alexander, D. Z., Hollenbaugh, D., Aruffo, A., Linsley, P. S., Thomas, E., Campbell, K., Fanslow, W. C., Geha, R. S., Morris, P. J., Wood, K. J. (1998). The Role of the CD40 Pathway in Alloantigen-Induced Hyporesponsiveness In Vivo. J. Immunol. 161: 5331-5337 [Abstract] [Full Text]
Johnson-Leger, C., Christenson, J. R., Holman, M., Klaus, G. G. B. (1998). Evidence for a Critical Role for IL-2 in CD40-Mediated Activation of Naive B Cells by Primary CD4 T Cells. J. Immunol. 161: 4618-4626 [Abstract] [Full Text]
Satterthwaite, A. B., Lowell, C. A., Khan, W. N., Sideras, P., Alt, F. W., Witte, O. N. (1998). Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways. JEM 188: 833-844 [Abstract] [Full Text]
Russell, J. Q., Mooney, T., Cohen, P. L., MacPherson, B., Noelle, R. J., Budd, R. C. (1998). Anti-CD40L Accelerates Renal Disease and Adenopathy in MRL-lpr Mice in Parallel with Decreased Thymocyte Apoptosis. J. Immunol. 161: 729-739 [Abstract] [Full Text]
Kato, J., Motoyama, N., Taniuchi, I., Takeshita, H., Toyoda, M., Masuda, K., Watanabe, T. (1998). Affinity Maturation in Lyn Kinase-Deficient Mice with Defective Germinal Center Formation. J. Immunol. 160: 4788-4795 [Abstract] [Full Text]
Toellner, K.-M., Luther, S. A., Sze, D. M.-Y., Choy, R. K.-W., Taylor, D. R., MacLennan, I. C.M., Acha-Orbea, H. (1998). T Helper 1�(Th1) and Th2 Characteristics Start to Develop During T Cell Priming and Are Associated with an Immediate Ability to Induce Immunoglobulin Class Switching. JEM 187: 1193-1204 [Abstract] [Full Text]
Zhou, P., Seder, R. A. (1998). CD40 Ligand Is Not Essential for Induction of Type 1�Cytokine Responses or Protective Immunity after Primary or Secondary Infection With Histoplasma capsulatum. JEM 187: 1315-1324 [Abstract] [Full Text]
Campos-Neto, A., Ovendale, P., Bement, T., Koppi, T. A., Fanslow, W. C., Rossi, M. A., Alderson, M. R. (1998). Cutting Edge: CD40 Ligand Is Not Essential for the Development of Cell-Mediated Immunity and Resistance to Mycobacterium tuberculosis. J. Immunol. 160: 2037-2041 [Abstract] [Full Text]
McDyer, J. F., Goletz, T. J., Thomas, E., June, C. H., Seder, R. A. (1998). CD40 Ligand/CD40 Stimulation Regulates the Production of IFN-{gamma} from Human Peripheral Blood Mononuclear Cells in an IL-12- and/or CD28-Dependent Manner. J. Immunol. 160: 1701-1707 [Abstract] [Full Text]
Caamano, J. H., Rizzo, C. A., Durham, S. K., Barton, D. S., Raventos-Suarez, C., Snapper, C. M., Bravo, R. (1998). Nuclear Factor (NF)-kappa B2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell-mediated Immune Responses. JEM 187: 185-196 [Abstract] [Full Text]
Sousa, C. R. e, Hieny, S., Scharton-Kersten, T., Jankovic, D., Charest, H., Germain, R. N., Sher, A. (1997). In Vivo Microbial Stimulation Induces Rapid CD40 Ligand-independent Production of Interleukin 12�by Dendritic Cells and their Redistribution to T Cell Areas. JEM 186: 1819-1829 [Abstract] [Full Text]