Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

doi:10.1084/jem.180.2.757

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

WR Godfrey, FF Fagnoni, MA Harara, D Buck and EG Engleman
Department of Pathology, Stanford University School of Medicine, California 94305.

The human OX-40 cell surface antigen is a CD4+ T cell activation marker that acts as a costimulatory receptor and is a member of the nerve growth factor receptor/tumor necrosis factor (TNF) receptor family. Using a soluble form of the receptor, the extracellular region fused with human immunoglobulin Fc, we expression cloned the human OX-40 ligand cDNA from a library derived from an activated B lymphoblastoid cell line MSAB. The encoded protein is identified as gp34, a type II transmembrane antigen previously known to be expressed only by human T cell lymphotropic virus 1-infected cells. We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation.
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Humphreys, I. R., Edwards, L., Walzl, G., Rae, A. J., Dougan, G., Hill, S., Hussell, T. (2003). OX40 Ligation on Activated T Cells Enhances the Control of Cryptococcus neoformans and Reduces Pulmonary Eosinophilia. J. Immunol. 170: 6125-6132 [Abstract] [Full Text]
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ATEN, J., ROOS, A., CLAESSEN, N., SCHILDER-TOL, E. J. M., TEN BERGE, I. J. M., WEENING, J. J. (2000). Strong and Selective Glomerular Localization of CD134 Ligand and TNF Receptor-1 in Proliferative Lupus Nephritis. J. Am. Soc. Nephrol. 11: 1426-1438 [Abstract] [Full Text]
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Pippig, S. D., Pena-Rossi, C., Long, J., Godfrey, W. R., Fowell, D. J., Reiner, S. L., Birkeland, M. L., Locksley, R. M., Barclay, A. N., Killeen, N. (1999). Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40). J. Immunol. 163: 6520-6529 [Abstract] [Full Text]
Souza, H S, Elia, C C S, Spencer, J, MacDonald, T T (1999). Expression of lymphocyte-endothelial receptor-ligand pairs, alpha 4beta 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut 45: 856-863 [Abstract] [Full Text]
Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., Nohara, C., Yagita, H., Okumura, K. (1999). CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells. J. Immunol. 162: 7058-7066 [Abstract] [Full Text]
Hollsberg, P. (1999). Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I. Microbiol. Mol. Biol. Rev. 63: 308-333 [Abstract] [Full Text]
Jones, D., Fletcher, C. D.M., Pulford, K., Shahsafaei, A., Dorfman, D. M. (1999). The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in Nonoverlapping Subsets of Peripheral T-Cell Lymphoma. Blood 93: 3487-3493 [Abstract] [Full Text]
Weinberg, A. D., Wegmann3, K. W., Funatake, C., Whitham, R. H. (1999). Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis. J. Immunol. 162: 1818-1826 [Abstract] [Full Text]
Higgins, L. M., McDonald, S. A. C., Whittle, N., Crockett, N., Shields, J. G., MacDonald, T. T. (1999). Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein. J. Immunol. 162: 486-493 [Abstract] [Full Text]
Gramaglia, I., Weinberg, A. D., Lemon, M., Croft, M. (1998). Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses. J. Immunol. 161: 6510-6517 [Abstract] [Full Text]
Ohshima, Y., Yang, L.-P., Uchiyama, T., Tanaka, Y., Baum, P., Sergerie, M., Hermann, P., Delespesse, G. (1998). OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4-Producing Effectors. Blood 92: 3338-3345 [Abstract] [Full Text]
Harrop, J. A., McDonnell, P. C., Brigham-Burke, M., Lyn, S. D., Minton, J., Tan, K. B., Dede, K., Spampanato, J., Silverman, C., Hensley, P., DiPrinzio, R., Emery, J. G., Deen, K., Eichman, C., Chabot-Fletcher, M., Truneh, A., Young, P. R. (1998). Herpesvirus Entry Mediator Ligand (HVEM-L), a Novel Ligand for HVEM/TR2, Stimulates Proliferation of T Cells and Inhibits HT29 Cell Growth. J. Biol. Chem. 273: 27548-27556 [Abstract] [Full Text]
Arch, R. H., Gedrich, R. W., Thompson, C. B. (1998). Tumor necrosis factor receptor-associated factors (TRAFs)---a family of adapter proteins that regulates life and death. Genes Dev. 12: 2821-2830 [Full Text]
Harrop, J. A., Reddy, M., Dede, K., Brigham-Burke, M., Lyn, S., Tan, K. B., Silverman, C., Eichman, C., DiPrinzio, R., Spampanato, J., Porter, T., Holmes, S., Young, P. R., Truneh, A. (1998). Antibodies to TR2 (Herpesvirus Entry Mediator), a New Member of the TNF Receptor Superfamily, Block T Cell Proliferation, Expression of Activation Markers, and Production of Cytokines. J. Immunol. 161: 1786-1794 [Abstract] [Full Text]
Ohtani, K., Tsujimoto, A., Tsukahara, T., Numata, N., Miura, S., Sugamura, K., Nakamura, M. (1998). Molecular Mechanisms of Promoter Regulation of the gp34 Gene That Is Trans-activated by an Oncoprotein Tax of Human T Cell Leukemia Virus Type I. J. Biol. Chem. 273: 14119-14129 [Abstract] [Full Text]
Zuckerman, L. A., Pullen, L., Miller, J. (1998). Functional Consequences of Costimulation by ICAM-1 on IL-2 Gene Expression and T Cell Activation. J. Immunol. 160: 3259-3268 [Abstract] [Full Text]
Kawamata, S., Hori, T., Imura, A., Takaori-Kondo, A., Uchiyama, T. (1998). Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2-�and TRAF5-mediated NF-kappa B Activation. J. Biol. Chem. 273: 5808-5814 [Abstract] [Full Text]
Thompson, R. H.�A. a. C. B. (1998). 4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor kappa B. Mol. Cell. Biol. 18: 558-565 [Abstract] [Full Text]
Hart, D. N.J. (1997). Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response. Blood 90: 3245-3287 [Full Text]
Tittle, T. V., Weinberg, A. D., Steinkeler, C. N., Maziarz, R. T. (1997). Expression of the T-Cell Activation Antigen, OX-40, Identifies Alloreactive T Cells in Acute Graft-Versus-Host Disease. Blood 89: 4652-4658 [Abstract] [Full Text]
Imura, A., Hori, T., Imada, K., Kawamata, S., Tanaka, Y., Imamura, S., Uchiyama, T. (1997). OX40 Expressed on Fresh Leukemic Cells From Adult T-Cell Leukemia Patients Mediates Cell Adhesion to Vascular Endothelial Cells: Implication for the Possible Involvement of OX40 in Leukemic Cell Infiltration. Blood 89: 2951-2958 [Abstract] [Full Text]
Tusher, V. G., Tibshirani, R., Chu, G. (2001). Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98: 5116-5121 [Abstract] [Full Text]