Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function

doi:10.1084/jem.180.2.705

This Article

	Full Text (PDF, 721K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by de Villiers, W. J.
	Articles by Gordon, S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by de Villiers, W. J.
	Articles by Gordon, S.


Social Bookmarking

	What's this?

ARTICLES

Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function

WJ de Villiers, IP Fraser, DA Hughes, AG Doyle and S Gordon
Sir William Dunn School of Pathology, University of Oxford, UK.

Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis. The effect of macrophage-colony-stimulating factor (M-CSF) on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M- CSF markedly and selectively increased MSR synthesis in murine macrophages: posttranslationally, the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally, M-CSF enhanced modified lipoprotein uptake and increased divalent cation- independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Ghia, J.-E., Galeazzi, F., Ford, D. C., Hogaboam, C. M., Vallance, B. A., Collins, S. (2008). Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G770-G777 [Abstract] [Full Text]
Lin, Y.-L., de Villiers, W. J. S., Garvy, B., Post, S. R., Nagy, T. R., Safadi, F. F., Faugere, M. C., Wang, G., Malluche, H. H., Williams, J. P. (2007). The Effect of Class A Scavenger Receptor Deficiency in Bone. J. Biol. Chem. 282: 4653-4660 [Abstract] [Full Text]
Arredouani, M. S., Yang, Z., Imrich, A., Ning, Y., Qin, G., Kobzik, L. (2006). The Macrophage Scavenger Receptor SR-AI/II and Lung Defense against Pneumococci and Particles. Am. J. Respir. Cell Mol. Bio. 35: 474-478 [Abstract] [Full Text]
Hagemann, T., Wilson, J., Burke, F., Kulbe, H., Li, N. F., Pluddemann, A., Charles, K., Gordon, S., Balkwill, F. R. (2006). Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype.. J. Immunol. 176: 5023-5032 [Abstract] [Full Text]
Jozefowski, S., Arredouani, M., Sulahian, T., Kobzik, L. (2005). Disparate Regulation and Function of the Class A Scavenger Receptors SR-AI/II and MARCO. J. Immunol. 175: 8032-8041 [Abstract] [Full Text]
Daugherty, A., Webb, N. R., Rateri, D. L., King, V. L. (2005). Thematic review series: The Immune System and Atherogenesis. Cytokine regulation of macrophage functions in atherogenesis. J. Lipid Res. 46: 1812-1822 [Abstract] [Full Text]
Subbarao, K., Jala, V. R., Mathis, S., Suttles, J., Zacharias, W., Ahamed, J., Ali, H., Tseng, M. T., Haribabu, B. (2004). Role of Leukotriene B4 Receptors in the Development of Atherosclerosis: Potential Mechanisms. Arterioscler. Thromb. Vasc. Bio. 24: 369-375 [Abstract] [Full Text]
Doyle, S. E., O'Connell, R. M., Miranda, G. A., Vaidya, S. A., Chow, E. K., Liu, P. T., Suzuki, S., Suzuki, N., Modlin, R. L., Yeh, W.-C., Lane, T. F., Cheng, G. (2004). Toll-like Receptors Induce a Phagocytic Gene Program through p38. JEM 199: 81-90 [Abstract] [Full Text]
Hamilton, J. A. (2003). Nondisposable materials, chronic inflammation, and adjuvant action. J. Leukoc. Biol. 73: 702-712 [Abstract] [Full Text]
de Beer, M. C., Zhao, Z., Webb, N. R., van der Westhuyzen, D. R., de Villiers, W. J. S. (2003). Lack of a direct role for macrosialin in oxidized LDL metabolism. J. Lipid Res. 44: 674-685 [Abstract] [Full Text]
Harshyne, L. A., Zimmer, M. I., Watkins, S. C., Barratt-Boyes, S. M. (2003). A Role for Class A Scavenger Receptor in Dendritic Cell Nibbling from Live Cells. J. Immunol. 170: 2302-2309 [Abstract] [Full Text]
Post, S. R., Gass, C., Rice, S., Nikolic, D., Crump, H., Post, G. R. (2002). Class A scavenger receptors mediate cell adhesion via activation of Gi/o and formation of focal adhesion complexes. J. Lipid Res. 43: 1829-1836 [Abstract] [Full Text]
Mitrasinovic, O. M., Murphy, G. M. Jr. (2002). Accelerated Phagocytosis of Amyloid-beta by Mouse and Human Microglia Overexpressing the Macrophage Colony-stimulating Factor Receptor. J. Biol. Chem. 277: 29889-29896 [Abstract] [Full Text]
Sato, O., Kuriki, C., Fukui, Y., Motojima, K. (2002). Dual Promoter Structure of Mouse and Human Fatty Acid Translocase/CD36 Genes and Unique Transcriptional Activation by Peroxisome Proliferator-activated Receptor alpha and gamma Ligands. J. Biol. Chem. 277: 15703-15711 [Abstract] [Full Text]
Akiyama, T. E., Sakai, S., Lambert, G., Nicol, C. J., Matsusue, K., Pimprale, S., Lee, Y.-H., Ricote, M., Glass, C. K., Brewer, H. B. Jr., Gonzalez, F. J. (2002). Conditional Disruption of the Peroxisome Proliferator-Activated Receptor {gamma} Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux. Mol. Cell. Biol. 22: 2607-2619 [Abstract] [Full Text]
Su, S.-H., Chen, H.-i., Jen, C. J. (2001). C57BL/6 and BALB/c Bronchoalveolar Macrophages Respond Differently to Exercise. J. Immunol. 167: 5084-5091 [Abstract] [Full Text]
Grewal, T., Priceputu, E., Davignon, J., Bernier, L. (2001). Identification of a {{gamma}}-Interferon-Responsive Element in the Promoter of the Human Macrophage Scavenger Receptor A Gene. Arterioscler. Thromb. Vasc. Bio. 21: 825-831 [Abstract] [Full Text]
Terpstra, V., van Amersfoort, E. S., van Velzen, A. G., Kuiper, J., van Berkel, T. J. C. (2000). Hepatic and Extrahepatic Scavenger Receptors : Function in Relation to Disease. Arterioscler. Thromb. Vasc. Bio. 20: 1860-1872 [Full Text]
Whitman, S. C., Daugherty, A., Post, S. R. (2000). Regulation of acetylated low density lipoprotein uptake in macrophages by pertussis toxin-sensitive G proteins. J. Lipid Res. 41: 807-813 [Abstract] [Full Text]
Peiser, L., Gough, P. J., Kodama, T., Gordon, S. (2000). Macrophage Class A Scavenger Receptor-Mediated Phagocytosis of Escherichia coli: Role of Cell Heterogeneity, Microbial Strain, and Culture Conditions In Vitro. Infect. Immun. 68: 1953-1963 [Abstract] [Full Text]
Cornicelli, J. A., Butteiger, D., Rateri, D. L., Welch, K., Daugherty, A. (2000). Interleukin-4 augments acetylated LDL-induced cholesterol esterification in macrophages. J. Lipid Res. 41: 376-383 [Abstract] [Full Text]
de Winther, M. P. J., van Dijk, K. W., Havekes, L. M., Hofker, M. H. (2000). Macrophage Scavenger Receptor Class A : A Multifunctional Receptor in Atherosclerosis. Arterioscler. Thromb. Vasc. Bio. 20: 290-297 [Abstract] [Full Text]
Thomas, C. A., Li, Y., Kodama, T., Suzuki, H., Silverstein, S. C., El Khoury, J. (2000). Protection from Lethal Gram-positive Infection by Macrophage Scavenger Receptor-dependent Phagocytosis. JEM 191: 147-156 [Abstract] [Full Text]
Lichanska, A. M., Browne, C. M., Henkel, G. W., Murphy, K. M., Ostrowski, M. C., McKercher, S. R., Maki, R. A., Hume, D. A. (1999). Differentiation of the Mononuclear Phagocyte System During Mouse Embryogenesis: The Role of Transcription Factor PU.1. Blood 94: 127-138 [Abstract] [Full Text]
Draude, G., von Hundelshausen, P., Frankenberger, M., Ziegler-Heitbrock, H. W.�L., Weber, C. (1999). Distinct scavenger receptor expression and function in the human CD14+/CD16+ monocyte subset. Am. J. Physiol. Heart Circ. Physiol. 276: H1144-H1149 [Abstract] [Full Text]
Gu, L., Johnson, M. W., Lusis, A. J. (1999). Quantitative Trait Locus Analysis of Plasma Lipoprotein Levels in an Autoimmune Mouse Model : Interactions Between Lipoprotein Metabolism, Autoimmune Disease, and Atherogenesis. Arterioscler. Thromb. Vasc. Bio. 19: 442-453 [Abstract] [Full Text]
Hamilton, J. A., Myers, D., Jessup, W., Cochrane, F., Byrne, R., Whitty, G., Moss, S. (1999). Oxidized LDL Can Induce Macrophage Survival, DNA Synthesis, and Enhanced Proliferative Response to CSF-1 and GM-CSF. Arterioscler. Thromb. Vasc. Bio. 19: 98-105 [Abstract] [Full Text]
Moore, K. J., Fabunmi, R. P., Andersson, L. P., Freeman, M. W. (1998). In Vitro�Differentiated Embryonic Stem Cell Macrophages : A Model System for Studying Atherosclerosis-Associated Macrophage Functions. Arterioscler. Thromb. Vasc. Bio. 18: 1647-1654 [Abstract] [Full Text]
Guidez, F., Li, A. C., Horvai, A., Welch, J. S., Glass, C. K. (1998). Differential Utilization of Ras Signaling Pathways by Macrophage Colony-Stimulating Factor (CSF) and Granulocyte-Macrophage CSF Receptors during Macrophage Differentiation. Mol. Cell. Biol. 18: 3851-3861 [Abstract] [Full Text]
Chang, M. Y., Olin, K. L., Tsoi, C., Wight, T. N., Chait, A. (1998). Human Monocyte-derived Macrophages Secrete Two Forms of Proteoglycan-Macrophage Colony-stimulating Factor That Differ in Their Ability to Bind Low Density Lipoproteins. J. Biol. Chem. 273: 15985-15992 [Abstract] [Full Text]
de Villiers, W. J. S., Smith, J. D., Miyata, M., Dansky, H. M., Darley, E., Gordon, S. (1998). Macrophage Phenotype in Mice Deficient in Both Macrophage-Colony�Stimulating Factor (Op) and Apolipoprotein E. Arterioscler. Thromb. Vasc. Bio. 18: 631-640 [Abstract] [Full Text]
Jessup, W., Squires, B., Kritharides, L., Hume, D. A., Dean, R. T. (1997). Effects of CSF-1 on Cholesterol Accumulation and Efflux by Macrophages. Arterioscler. Thromb. Vasc. Bio. 17: 18-25 [Abstract] [Full Text]
Hsu, H.-Y., Nicholson, A. C., Hajjar, D. P. (1996). Inhibition of Macrophage Scavenger Receptor Activity by Tumor Necrosis Factor-alpha Is Transcriptionally and Post-transcriptionally Regulated. J. Biol. Chem. 271: 7767-7773 [Abstract] [Full Text]
Whitman, S. C., Daugherty, A., Post, S. R. (2000). Macrophage Colony-stimulating Factor Rapidly Enhances beta -Migrating Very Low Density Lipoprotein Metabolism in Macrophages through Activation of a Gi/o Protein Signaling Pathway. J. Biol. Chem. 275: 35807-35813 [Abstract] [Full Text]