Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

doi:10.1084/jem.179.5.1725

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Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

T Kurosaki, M Takata, Y Yamanashi, T Inazu, T Taniguchi, T Yamamoto and H Yamamura
Department of Cardiovascular Molecular Biology, Lederle Laboratories, Pearl River, New York 10965.

Signaling through the B cell antigen receptor (BCR) results in rapid increases in tyrosine phosphorylation on a number of proteins. The BCR associates with two classes of tyrosine kinase: Src-family kinase (Src- protein-tyrosine kinase [PTK]; Lyn, Fyn, Blk, or Lck) and Syk kinase. We have investigated the interaction between the Src-PTK and the Syk kinase in the BCR signaling. In contrast to wild-type B cells, BCR- mediated tyrosine phosphorylation of Syk and activation of its in vitro kinase activity were profoundly reduced in lyn-negative cells. The requirement of the Src-PTK to induce tyrosine phosphorylation and activation of Syk was also demonstrated by cotransfection of syk and src-PTK cDNAs into COS cells. These results suggest that the Src-PTK associated with BCR phosphorylates the tyrosine residue(s) of Syk upon receptor stimulation, enhancing the activity of Syk.
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Weil, R., Levraud, J.-P., Dodon, M. D., Bessia, C., Hazan, U., Kourilsky, P., Israël, A. (1999). Altered Expression of Tyrosine Kinases of the Src and Syk Families in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines. J. Virol. 73: 3709-3717 [Abstract] [Full Text]
Duprez, V., Blank, U., Chretien, S., Gisselbrecht, S., Mayeux, P. (1998). Physical and Functional Interaction between p72syk and Erythropoietin Receptor. J. Biol. Chem. 273: 33985-33990 [Abstract] [Full Text]
Yamaguchi-Iwai, Y., Sonoda, E., Buerstedde, J.-M., Bezzubova, O., Morrison, C., Takata, M., Shinohara, A., Takeda, S. (1998). Homologous Recombination, but Not DNA Repair, Is Reduced in Vertebrate Cells Deficient in RAD52. Mol. Cell. Biol. 18: 6430-6435 [Abstract] [Full Text]
Murray, E. W., Robbins, S. M. (1998). Antibody Cross-linking of the Glycosylphosphatidylinositol-linked Protein CD59 on Hematopoietic Cells Induces Signaling Pathways Resembling Activation by Complement. J. Biol. Chem. 273: 25279-25284 [Abstract] [Full Text]
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Dibirdik, I., Kristupaitis, D., Kurosaki, T., Tuel-Ahlgren, L., Chu, A., Pond, D., Tuong, D., Luben, R., Uckun, F. M. (1998). Stimulation of Src Family Protein-tyrosine Kinases as a Proximal and Mandatory Step for SYK Kinase-dependent Phospholipase Cgamma 2 Activation in Lymphoma B Cells Exposed to Low Energy Electromagnetic Fields. J. Biol. Chem. 273: 4035-4039 [Abstract] [Full Text]
Honda, Z.-i., Suzuki, T., Hirose, N., Aihara, M., Shimizu, T., Nada, S., Okada, M., Ra, C., Morita, Y., Ito, K. (1997). Roles of C-terminal Src Kinase in the Initiation and the Termination of the High Affinity IgE Receptor-mediated Signaling. J. Biol. Chem. 272: 25753-25760 [Abstract] [Full Text]
Cheng, A. M., Negishi, I., Anderson, S. J., Chan, A. C., Bolen, J., Loh, D. Y., Pawson, T. (1997). The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor�signaling. Proc. Natl. Acad. Sci. USA 94: 9797-9801 [Abstract] [Full Text]
Li, H.-L., Forman, M. S., Kurosaki, T., Pure, E. (1997). Syk Is Required for BCR-mediated Activation of p90Rsk, but Not p70S6k, via a Mitogen-activated Protein Kinase-independent Pathway in B Cells. J. Biol. Chem. 272: 18200-18208 [Abstract] [Full Text]
Vitetta, E. S., Tucker, T. F., Racila, E., Huang, Y.-W., Marches, R., Lane, N., Scheuermann, R. H., Street, N. E., Watanabe, T., Uhr, J. W. (1997). Tumor Dormancy and Cell Signaling. V.�Regrowth of the BCL1 Tumor After Dormancy Is Established. Blood 89: 4425-4436 [Abstract] [Full Text]
Chung, J., Gao, A.-G., Frazier, W. A. (1997). Thrombspondin Acts via Integrin-associated Protein to Activate the Platelet Integrin alpha IIbbeta 3. J. Biol. Chem. 272: 14740-14746 [Abstract] [Full Text]
Krejsa, C. M., Nadler, S. G., Esselstyn, J. M., Kavanagh, T. J., Ledbetter, J. A., Schieven, G. L. (1997). Role of Oxidative Stress in the Action of Vanadium Phosphotyrosine Phosphatase Inhibitors. REDOX INDEPENDENT ACTIVATION OF NF-kappa B. J. Biol. Chem. 272: 11541-11549 [Abstract] [Full Text]
Keshvara, L. M., Isaacson, C., Harrison, M. L., Geahlen, R. L. (1997). Syk Activation and Dissociation from the B-cell Antigen Receptor Is Mediated by Phosphorylation of Tyrosine 130. J. Biol. Chem. 272: 10377-10381 [Abstract] [Full Text]
Lahti, J. M., Li, H., Kidd, V. J. (1997). Elimination of Cyclin D1 in Vertebrate Cells Leads to an Altered Cell Cycle Phenotype, Which Is Rescued by Overexpression of Murine Cyclins D1, D2, or D3 but Not by a Mutant Cyclin D1. J. Biol. Chem. 272: 10859-10869 [Abstract] [Full Text]
Yamanashi, Y., Fukuda, T., Nishizumi, H., Inazu, T., Higashi, K.-i., Kitamura, D., Ishida, T., Yamamura, H., Watanabe, T., Yamamoto, T. (1997). Role of Tyrosine Phosphorylation of HS1 in B Cell Antigen Receptor-mediated Apoptosis. JEM 185: 1387-1392 [Abstract] [Full Text]
Fitzer-Attas, C. J., Schindler, D. G., Waks, T., Eshhar, Z. (1997). Direct T Cell Activation by Chimeric Single Chain Fv-Syk Promotes Syk-Cbl Association and Cbl Phosphorylation. J. Biol. Chem. 272: 8551-8557 [Abstract] [Full Text]
El-Hillal, O., Kurosaki, T., Yamamura, H., Kinet, J.-P., Scharenberg, A. M. (1997). syk kinase activation by a src kinase-initiated activation loop phosphorylation chain�reaction. Proc. Natl. Acad. Sci. USA 94: 1919-1924 [Abstract] [Full Text]
Qin, S., Minami, Y., Hibi, M., Kurosaki, T., Yamamura, H. (1997). Syk-dependent and -independent Signaling Cascades in B Cells Elicited by Osmotic and Oxidative Stress. J. Biol. Chem. 272: 2098-2103 [Abstract] [Full Text]
Taylor, N., Jahn, T., Smith, S., Lamkin, T., Uribe, L., Liu, Y., Durden, D. L., Weinberg, K. (1997). Differential Activation of the Tyrosine Kinases ZAP-70 and Syk After Fcgamma RI Stimulation. Blood 89: 388-396 [Abstract] [Full Text]
Yanagi, S., Sugawara, H., Kurosaki, M., Sabe, H., Yamamura, H., Kurosaki, T. (1996). CD45 Modulates Phosphorylation of Both Autophosphorylation and Negative Regulatory Tyrosines of Lyn in B Cells. J. Biol. Chem. 271: 30487-30492 [Abstract] [Full Text]
Latour, S., Chow, L. M.L., Veillette, A. (1996). Differential Intrinsic Enzymatic Activity of Syk and Zap-70 Protein-tyrosine Kinases. J. Biol. Chem. 271: 22782-22790 [Abstract] [Full Text]
Haimovich, B., Regan, C., DiFazio, L., Ginalis, E., Ji, P., Purohit, U., Rowley, R. B., Bolen, J., Greco, R. (1996). The Fcgamma RII Receptor Triggers pp125FAK Phosphorylation in Platelets. J. Biol. Chem. 271: 16332-16337 [Abstract] [Full Text]
Chacko, G. W., Brandt, J. T., Coggeshall, K. M., Anderson, C. L. (1996). Phosphoinositide 3-Kinase and p72[IMAGE] Noncovalently Associate with the Low Affinity Fc[IMAGE] Receptor on Human Platelets through an Immunoreceptor Tyrosine-based Activation Motif. J. Biol. Chem. 271: 10775-10781 [Abstract] [Full Text]
Maruyama, S., Kurosaki, T., Sada, K., Yamanashi, Y., Yamamoto, T., Yamamura, H. (1996). Physical and Functional Association of Cortactin with Syk in Human Leukemic Cell Line K562. J. Biol. Chem. 271: 6631-6635 [Abstract] [Full Text]
Gibson, S., August, A., Branch, D., Dupont, B., Mills, G. B. (1996). Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK. J. Biol. Chem. 271: 7079-7083 [Abstract] [Full Text]
Richards, J. D., Gold, M. R., Hourihane, S. L., DeFranco, A. L., Matsuuchi, L. (1996). Reconstitution of B Cell Antigen Receptor-induced Signaling Events in a Nonlymphoid Cell Line by Expressing the Syk Protein-tyrosine Kinase. J. Biol. Chem. 271: 6458-6466 [Abstract] [Full Text]
Panchamoorthy, G., Fukazawa, T., Miyake, S., Soltoff, S., Reedquist, K., Druker, B., Shoelson, S., Cantley, L., Band, H. (1996). p120[IMAGE] Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase. J. Biol. Chem. 271: 3187-3194 [Abstract] [Full Text]
Kim, T. J., Kim, Y.-T., Pillai, S. (1995). Association of Activated Phosphatidylinositol 3-Kinase with p120[IMAGE] in Antigen Receptor-ligated B Cells. J. Biol. Chem. 270: 27504-27509 [Abstract] [Full Text]
Katagiri, T., Ogimoto, M., Hasegawa, K., Mizuno, K., Yakura, H. (1995). Selective Regulation of Lyn Tyrosine Kinase by CD45 in Immature B Cells. J. Biol. Chem. 270: 27987-27990 [Abstract] [Full Text]
Uckun, F. M., Kurosaki, T., Jin, J., Jun, X., Morgan, A., Takata, M., Bolen, J., Luben, R. (1995). Exposure of B-lineage Lymphoid Cells to Low Energy Electromagnetic Fields Stimulates Lyn Kinase. J. Biol. Chem. 270: 27666-27670 [Abstract] [Full Text]
Schieven, G. L., Wahl, A. F., Myrdal, S., Grosmaire, L., Ledbetter, J. A. (1995). Lineage-specific Induction of B Cell Apoptosis and Altered Signal Transduction by the Phosphotyrosine Phosphatase Inhibitor Bis(maltolato)oxovanadium(IV). J. Biol. Chem. 270: 20824-20831 [Abstract] [Full Text]
Ting, A. T., Dick, C. J., Schoon, R. A., Karnitz, L. M., Abraham, R. T., Leibson, P. J. (1995). Interaction between lck and syk Family Tyrosine Kinases in Fc[IMAGE] Receptor-initiated Activation of Natural Killer Cells. J. Biol. Chem. 270: 16415-16421 [Abstract] [Full Text]
Aoki, Y., Kim, Y.-T., Stillwell, R., Kim, T. J., Pillai, S. (1995). The SH2 Domains of Src Family Kinases Associate with Syk. J. Biol. Chem. 270: 15658-15663 [Abstract] [Full Text]
Sillman, A. L., Monroe, J. G. (1995). Association of p72[IMAGE] with the src Homology-2 (SH2) Domains of PLC[IMAGE]1 in B Lymphocytes. J. Biol. Chem. 270: 11806-11811 [Abstract] [Full Text]
Shiue, L., Zoller, M. J., Brugge, J. S. (1995). Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE. J. Biol. Chem. 270: 10498-10502 [Abstract] [Full Text]
Nagai, K., Takata, M., Yamamura, H., Kurosaki, T. (1995). Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling. J. Biol. Chem. 270: 6824-6829 [Abstract] [Full Text]
Tabata, H., Matsuoka, T., Endo, F., Nishimura, Y., Matsushita, S. (2000). Ligation of HLA-DR Molecules on B Cells Induces Enhanced Expression of IgM Heavy Chain Genes in Association with Syk Activation. J. Biol. Chem. 275: 34998-35005 [Abstract] [Full Text]
Zhang, J., Billingsley, M. L., Kincaid, R. L., Siraganian, R. P. (2000). Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function. AN IN VIVO STUDY USING A SPECIFIC ANTI-Syk ACTIVATION LOOP PHOSPHOTYROSINE ANTIBODY. J. Biol. Chem. 275: 35442-35447 [Abstract] [Full Text]
Bourguignon, L. Y. W., Zhu, H., Shao, L., Chen, Y.-W. (2001). CD44 Interaction with c-Src Kinase Promotes Cortactin-mediated Cytoskeleton Function and Hyaluronic Acid-dependent Ovarian Tumor Cell Migration. J. Biol. Chem. 276: 7327-7336 [Abstract] [Full Text]
Somani, A.-K., Yuen, K., Xu, F., Zhang, J., Branch, D. R., Siminovitch, K. A. (2001). The SH2 Domain Containing Tyrosine Phosphatase-1 Down-regulates Activation of Lyn and Lyn-induced Tyrosine Phosphorylation of the CD19 Receptor in B Cells. J. Biol. Chem. 276: 1938-1944 [Abstract] [Full Text]
Paolini, R., Molfetta, R., Piccoli, M., Frati, L., Santoni, A. (2001). Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement. Proc. Natl. Acad. Sci. USA 98: 9611-9616 [Abstract] [Full Text]