Borna disease virus-specific T cells protect against or cause immunopathological Borna disease

doi:10.1084/jem.179.5.1467

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Borna disease virus-specific T cells protect against or cause immunopathological Borna disease

JA Richt, A Schmeel, K Frese, KM Carbone, O Narayan and R Rott
Institut fur Virologie, Giessen, Germany.

In this report we show that passive immunization of Lewis rats with viable CD4+, Borna disease virus (BDV)-specific T cells before infection with BDV resulted in protection against BD, whereas inoculation of these T cells after BDV infection induced clinical disease with more rapid onset than seen in BDV control animals. The protective as well as encephalitogenic effector functions of BDV- specific CD4+ T cells were mediated only by viable BDV-specific T cells. The protective situation was obtained by passive transfer of BDV- specific T cells into animals inoculated later with virus, whereas the immunopathological situation was observed when virus-specific T cells developed normally or after adoptive transfer, and appeared on the scene after considerable virus replication in the brain.
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