B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens

doi:10.1084/jem.179.5.1457

This Article

	Full Text (PDF, 1155K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Beutner, U.
	Articles by Huber, B. T.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Beutner, U.
	Articles by Huber, B. T.


Social Bookmarking

	What's this?

ARTICLES

B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens

U Beutner, E Kraus, D Kitamura, K Rajewsky and BT Huber
Program of Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111.

Murine mammary tumor viruses (MMTVs) are retroviruses that encode superantigens capable of stimulating T cells via superantigen-reactive T cell receptor V beta chains. MMTVs are transmitted to the suckling offspring through milk. Here we show that B cell-deficient mice foster nursed by virus-secreting mice do not transfer infectious MMTVs to their offspring. No MMTV proviruses could be detected in the spleen and mammary tissue of these mice, and no deletion of MMTV superantigen- reactive T cells occurred. By contrast, T cell deletion and positive selection due to endogenous MMTV superantigens occurred in B cell- deficient mice. We conclude that B cells are essential for the completion of the viral life cycle in vivo, but that endogenous MMTV superantigens can be presented by cell types other than B cells.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Cabrera, G., Burzyn, D., Mundinano, J., Courreges, M. C., Camicia, G., Lorenzo, D., Costa, H., Ross, S. R., Nepomnaschy, I., Piazzon, I. (2008). Early Increases in Superantigen-Specific Foxp3+ Regulatory T Cells during Mouse Mammary Tumor Virus Infection. J. Virol. 82: 7422-7431 [Abstract] [Full Text]
Okeoma, C. M., Shen, M., Ross, S. R. (2008). A Novel Block to Mouse Mammary Tumor Virus Infection of Lymphocytes in B10.BR Mice. J. Virol. 82: 1314-1322 [Abstract] [Full Text]
Courreges, M. C., Burzyn, D., Nepomnaschy, I., Piazzon, I., Ross, S. R. (2007). Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo Infection. J. Virol. 81: 3769-3777 [Abstract] [Full Text]
MacDearmid, C. C., Case, L. K., Starling, C. L., Golovkina, T. V. (2006). Gradual Elimination of Retroviruses in YBR/Ei Mice. J. Virol. 80: 2206-2215 [Abstract] [Full Text]
Case, L. K., Purdy, A., Golovkina, T. V. (2005). Molecular and Cellular Basis of the Retrovirus Resistance in I/LnJ Mice. J. Immunol. 175: 7543-7549 [Abstract] [Full Text]
Pobezinskaya, Y., Chervonsky, A. V., Golovkina, T. V. (2004). Initial Stages of Mammary Tumor Virus Infection Are Superantigen Independent. J. Immunol. 172: 5582-5587 [Abstract] [Full Text]
Burzyn, D., Rassa, J. C., Kim, D., Nepomnaschy, I., Ross, S. R., Piazzon, I. (2004). Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by a Retrovirus. J. Virol. 78: 576-584 [Abstract] [Full Text]
Ali, M., Weinreich, M., Balcaitis, S., Cooper, C. J., Fink, P. J. (2003). Differential Regulation of Peripheral CD4+ T Cell Tolerance Induced by Deletion and TCR Revision. J. Immunol. 171: 6290-6296 [Abstract] [Full Text]
Mpandi, M., Otten, L. A., Lavanchy, C., Acha-Orbea, H., Finke, D. (2003). Passive Immunization with Neutralizing Antibodies Interrupts the Mouse Mammary Tumor Virus Life Cycle. J. Virol. 77: 9369-9377 [Abstract] [Full Text]
Finke, D., Luther, S. A., Acha-Orbea, H. (2003). The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development. Proc. Natl. Acad. Sci. USA 100: 199-204 [Abstract] [Full Text]
Vacheron, S., Luther, S. A., Acha-Orbea, H. (2002). Preferential Infection of Immature Dendritic Cells and B Cells by Mouse Mammary Tumor Virus. J. Immunol. 168: 3470-3476 [Abstract] [Full Text]
Rassa, J. C., Meyers, J. L., Zhang, Y., Kudaravalli, R., Ross, S. R. (2002). Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc. Natl. Acad. Sci. USA 99: 2281-2286 [Abstract] [Full Text]
Ramakrishna, C., Stohlman, S. A., Atkinson, R. D., Shlomchik, M. J., Bergmann, C. C. (2002). Mechanisms of Central Nervous System Viral Persistence: the Critical Role of Antibody and B Cells. J. Immunol. 168: 1204-1211 [Abstract] [Full Text]
Ceredig, R. (2002). The ontogeny of B cells in the thymus of normal, CD3{varepsilon} knockout (KO), RAG-2 KO and IL-7 transgenic mice. Int Immunol 14: 87-99 [Abstract] [Full Text]
Chiu, P. P. L., Jevnikar, A. M., Danska, J. S. (2001). Genetic Control of T and B Lymphocyte Activation in Nonobese Diabetic Mice. J. Immunol. 167: 7169-7179 [Abstract] [Full Text]
Li, R., Page, D. M. (2001). Requirement for a Complex Array of Costimulators in the Negative Selection of Autoreactive Thymocytes In Vivo. J. Immunol. 166: 6050-6056 [Abstract] [Full Text]
Finke, D., Baribaud, F., Diggelmann, H., Acha-Orbea, H. (2001). Extrafollicular Plasmablast B Cells Play a Key Role in Carrying Retroviral Infection to Peripheral Organs. J. Immunol. 166: 6266-6275 [Abstract] [Full Text]
Golovkina, T. V., Agafonova, Y., Kazansky, D., Chervonsky, A. (2001). Diverse Repertoire of the MHC Class II-Peptide Complexes Is Required for Presentation of Viral Superantigens. J. Immunol. 166: 2244-2250 [Abstract] [Full Text]
Mustafa, F., Lozano, M., Dudley, J. P. (2000). C3H Mouse Mammary Tumor Virus Superantigen Function Requires a Splice Donor Site in the Envelope Gene. J. Virol. 74: 9431-9440 [Abstract] [Full Text]
Hook, L. M., Agafonova, Y., Ross, S. R., Turner, S. J., Golovkina, T. V. (2000). Genetics of Mouse Mammary Tumor Virus-Induced Mammary Tumors: Linkage of Tumor Induction to the gag Gene. J. Virol. 74: 8876-8883 [Abstract] [Full Text]
Reuss, F. U., Coffin, J. M. (2000). The Mouse Mammary Tumor Virus Transcription Enhancers for Hematopoietic Progenitor and Mammary Gland Cells Share Functional Elements. J. Virol. 74: 8183-8187 [Abstract] [Full Text]
Zhu, Q., Gregg, K., Lozano, M., Liu, J., Dudley, J. P. (2000). CDP Is a Repressor of Mouse Mammary Tumor Virus Expression in the Mammary Gland. J. Virol. 74: 6348-6357 [Abstract] [Full Text]
Kleindienst, P., Chretien, I., Winkler, T., Brocker, T. (2000). Functional comparison of thymic B cells and dendritic cells in vivo. Blood 95: 2610-2616 [Abstract] [Full Text]
Golovkina, T. V. (2000). A Novel Mechanism of Resistance to Mouse Mammary Tumor Virus Infection. J. Virol. 74: 2752-2759 [Abstract] [Full Text]
Golovkina, T. V., Shlomchik, M., Hannum, L., Chervonsky, A. (1999). Organogenic Role of B Lymphocytes in Mucosal Immunity. Science 286: 1965-1968 [Abstract] [Full Text]
Baribaud, F., Maillard, I., Vacheron, S., Brocker, T., Diggelmann, H., Acha-Orbea, H. (1999). Role of Dendritic Cells in the Immune Response Induced by Mouse Mammary Tumor Virus Superantigen. J. Virol. 73: 8403-8410 [Abstract] [Full Text]
Barnett, A., Mustafa, F., Wrona, T. J., Lozano, M., Dudley, J. P. (1999). Expression of Mouse Mammary Tumor Virus Superantigen mRNA in the Thymus Correlates with Kinetics of Self-Reactive T-Cell Loss. J. Virol. 73: 6634-6645 [Abstract] [Full Text]
Liu, J., Barnett, A., Neufeld, E. J., Dudley, J. P. (1999). Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation. Mol. Cell. Biol. 19: 4918-4926 [Abstract] [Full Text]
Dautigny, N., Le Campion, A., Lucas, B. (1999). Timing and Casting for Actors of Thymic Negative Selection. J. Immunol. 162: 1294-1302 [Abstract] [Full Text]
Qin, W., Golovkina, T. V., Peng, T., Nepomnaschy, I., Buggiano, V., Piazzon, I., Ross, S. R. (1999). Mammary Gland Expression of Mouse Mammary Tumor Virus Is Regulated by a Novel Element in the Long Terminal Repeat. J. Virol. 73: 368-376 [Abstract] [Full Text]
Sharma, M. D., Leite de Moraes, M., Zavala, F., Pontoux, C., Papiernik, M. (1998). Induction and Inhibition of CD40-CD40 Ligand Interactions: A New Strategy Underlying Host-Virus Relationships. J. Immunol. 161: 5357-5365 [Abstract] [Full Text]
Golovkina, T. V., Dudley, J. P., Ross, S. R. (1998). B and T Cells Are Required for Mouse Mammary Tumor Virus Spread Within the Mammary Gland. J. Immunol. 161: 2375-2382 [Abstract] [Full Text]
Reuss, F. U., Coffin, J. M. (1998). Mouse Mammary Tumor Virus Superantigen Expression in B Cells Is Regulated by a Central Enhancer within the pol Gene. J. Virol. 72: 6073-6082 [Abstract] [Full Text]
Wrona, T. J., Lozano, M., Binhazim, A. A., Dudley, J. P. (1998). Mutational and Functional Analysis of the C-Terminal Region of the C3H Mouse Mammary Tumor Virus Superantigen. J. Virol. 72: 4746-4755 [Abstract] [Full Text]
Grigg, M. E., McMahon, C. W., Morkowski, S., Rudensky, A. Y., Pullen, A. M. (1998). Mtv-1 Superantigen Trafficks Independently of Major Histocompatibility Complex Class II Directly to the B-Cell Surface by the Exocytic Pathway. J. Virol. 72: 2577-2588 [Abstract] [Full Text]
Golovkina, T. V., Dzuris, J., van den Hoogen, B., Jaffe, A. B., Wright, P. C., Cofer, S. M., Ross, S. R. (1998). A Novel Membrane Protein Is a Mouse Mammary Tumor Virus Receptor. J. Virol. 72: 3066-3071 [Abstract] [Full Text]
Wang, H., Shlomchik, M. J. (1998). Maternal Ig Mediates Neonatal Tolerance in Rheumatoid Factor Transgenic Mice but Tolerance Breaks Down in Adult Mice. J. Immunol. 160: 2263-2271 [Abstract] [Full Text]
Ferrero, I., Anjuere, F., Robson MacDonald, H., Ardavin, C. (1997). In Vitro Negative Selection of Viral Superantigen-Reactive Thymocytes by Thymic Dendritic Cells. Blood 90: 1943-1951 [Abstract] [Full Text]
Luther, S. A., Gulbranson-Judge, A., Acha-Orbea, H., MacLennan, I. C.M. (1997). Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production. JEM 185: 551-562 [Abstract] [Full Text]