Prevention of nephritis in major histocompatibility complex class II- deficient MRL-lpr mice

doi:10.1084/jem.179.4.1137

This Article

	Full Text (PDF, 1435K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Jevnikar, A. M.
	Articles by Glimcher, L. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Jevnikar, A. M.
	Articles by Glimcher, L. H.


Social Bookmarking

	What's this?

ARTICLES

Prevention of nephritis in major histocompatibility complex class II- deficient MRL-lpr mice

AM Jevnikar, MJ Grusby and LH Glimcher
Robarts Research Institute, University of Western Ontario, London, Canada.

MRL-lpr mice develop aggressive autoimmune kidney disease associated with increased or de novo renal expression of major histocompatibility complex (MHC) class II molecules and a massive systemic expansion of CD4-CD- double negative (DN) T cells. Whereas non-MHC linked genes can have a profound effect on the development of nephritis, lymphadenopathy, and anti-DNA antibody production in MRL-lpr mice, the role of MHC molecules has not been unequivocally established. To study the role of MHC class II in this murine model of systemic lupus erythematosis, class II-deficient MRL-lpr mice (MRL-lpr -/-) were created. MRL-lpr -/- mice developed lymphadenopathy but not autoimmune renal disease or autoantibodies. This study demonstrates that class II expression is critical for the development of autoaggressive CD4+ T cells involved in autoimmune nephritis and clearly dissociates DN T cell expansion from autoimmune disease initiation.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Puliaev, R., Puliaeva, I., Welniak, L. A., Ryan, A. E., Haas, M., Murphy, W. J., Via, C. S. (2008). CTL-Promoting Effects of CD40 Stimulation Outweigh B Cell-Stimulatory Effects Resulting in B Cell Elimination and Disease Improvement in a Murine Model of Lupus. J. Immunol. 181: 47-61 [Abstract] [Full Text]
Herber, D., Brown, T. P., Liang, S., Young, D. A., Collins, M., Dunussi-Joannopoulos, K. (2007). IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R.Fc Reduces Disease Progression. J. Immunol. 178: 3822-3830 [Abstract] [Full Text]
Sekine, H., Graham, K. L., Zhao, S., Elliott, M. K., Ruiz, P., Utz, P. J., Gilkeson, G. S. (2006). Role of MHC-Linked Genes in Autoantigen Selection and Renal Disease in a Murine Model of Systemic Lupus Erythematosus. J. Immunol. 177: 7423-7434 [Abstract] [Full Text]
Beaudette-Zlatanova, B. C., Ling, T., Shlomchik, M. J., Marshak-Rothstein, A., Rifkin, I. R. (2006). B Cells and Dendritic Cells from V{kappa}8 Light Chain Transgenic Mice Activate MRL-lpr/gld CD4+ T Cells. J. Immunol. 177: 45-52 [Abstract] [Full Text]
Guo, W., Smith, D., Guth, A., Aviszus, K., Wysocki, L. J. (2005). T Cell Tolerance to Germline-Encoded Antibody Sequences in a Lupus-Prone Mouse. J. Immunol. 175: 2184-2190 [Abstract] [Full Text]
Zielinski, C. E., Jacob, S. N., Bouzahzah, F., Ehrlich, B. E., Craft, J. (2005). Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation. J. Immunol. 174: 5100-5109 [Abstract] [Full Text]
Jury, E C, Ehrenstein, M R (2005). Statins: immunomodulators for autoimmune rheumatic disease?. Lupus 14: 192-196 [Abstract]
Lawman, S., Mauri, C., Jury, E. C., Cook, H. T., Ehrenstein, M. R. (2004). Atorvastatin Inhibits Autoreactive B Cell Activation and Delays Lupus Development in New Zealand Black/White F1 Mice. J. Immunol. 173: 7641-7646 [Abstract] [Full Text]
Reilly, C. M., Mishra, N., Miller, J. M., Joshi, D., Ruiz, P., Richon, V. M., Marks, P. A., Gilkeson, G. S. (2004). Modulation of Renal Disease in MRL/lpr Mice by Suberoylanilide Hydroxamic Acid. J. Immunol. 173: 4171-4178 [Abstract] [Full Text]
Busser, B. W., Cancro, M. P., Laufer, T. M. (2004). An increased frequency of autoantibody-inducing CD4+ T cells in pre-diseased lupus-prone mice. Int Immunol 16: 1001-1007 [Abstract] [Full Text]
Seagal, J., Leider, N., Wildbaum, G., Karin, N., Melamed, D. (2003). Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Ig{micro}-deficient/lpr mice. Int Immunol 15: 1045-1052 [Abstract] [Full Text]
Catterall, T., Stockwell, D., Marshall, V., Strasser, A., Allison, J. (2003). Autoimmune kidney disease and lymphadenopathy in NODlpr mice are not modified by deficiency in tumor necrosis factor receptor 1 or {beta}2-microglobulin. Int Immunol 15: 679-690 [Abstract] [Full Text]
Henderson, S. C., Kamdar, M. M., Bamezai, A. (2002). Ly-6A.2 Expression Regulates Antigen-Specific CD4+ T Cell Proliferation and Cytokine Production. J. Immunol. 168: 118-126 [Abstract] [Full Text]
Freed, J. H., Marrs, A., VanderWall, J., Cohen, P. L., Eisenberg, R. A. (2000). MHC Class II-Bound Self Peptides from Autoimmune MRL/lpr Mice Reveal Potential T Cell Epitopes for Autoantibody Production in Murine Systemic Lupus Erythematosus. J. Immunol. 164: 4697-4705 [Abstract] [Full Text]
Schwarting, A., Tesch, G., Kinoshita, K., Maron, R., Weiner, H. L., Kelley, V. R. (1999). IL-12 Drives IFN-{gamma}-Dependent Autoimmune Kidney Disease in MRL-Faslpr Mice. J. Immunol. 163: 6884-6891 [Abstract] [Full Text]
Zavala, F., Masson, A., Hadaya, K., Ezine, S., Schneider, E., Babin, O., Bach, J.-F. (1999). Granulocyte-Colony Stimulating Factor Treatment of Lupus Autoimmune Disease in MRL-lpr/lpr Mice. J. Immunol. 163: 5125-5132 [Abstract] [Full Text]
Tada, Y., Nagasawa, K., Ho, A., Morito, F., Koarada, S., Ushiyama, O., Suzuki, N., Ohta, A., Mak, T. W. (1999). Role of the Costimulatory Molecule CD28 in the Development of Lupus in MRL/lpr Mice. J. Immunol. 163: 3153-3159 [Abstract] [Full Text]
Liang, B., Gee, R. J., Kashgarian, M. J., Sharpe, A. H., Mamula, M. J. (1999). B7 Costimulation in the Development of Lupus: Autoimmunity Arises Either in the Absence of B7.1/B7.2 or in the Presence of Anti-B7.1/B7.2 Blocking Antibodies. J. Immunol. 163: 2322-2329 [Abstract] [Full Text]
Mamula, M. J., Gee, R. J., Elliott, J. I., Sette, A., Southwood, S., Jones, P.-J., Blier, P. R. (1999). Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins. J. Biol. Chem. 274: 22321-22327 [Abstract] [Full Text]
Seery, J. P., Wang, E. C. Y., Cattell, V., Carroll, J. M., Owen, M. J., Watt, F. M. (1999). A Central Role for {alpha}{beta} T Cells in the Pathogenesis of Murine Lupus. J. Immunol. 162: 7241-7248 [Abstract] [Full Text]
Mandik-Nayak, L., Seo, S.-j., Sokol, C., Potts, K. M., Bui, A., Erikson, J. (1999). MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti-double-stranded DNA B Cells. JEM 189: 1799-1814 [Abstract] [Full Text]
Pestano, G. A., Zhou, Y., Trimble, L. A., Daley, J., Weber, G. F., Cantor, H. (1999). Inactivation of Misselected CD8 T Cells by CD8 Gene Methylation and Cell Death. Science 284: 1187-1191 [Abstract] [Full Text]
Fatenejad, S., Peng, S. L., Disorbo, O., Craft, J. (1998). Central T Cell Tolerance in Lupus-Prone Mice: Influence of Autoimmune Background and the lpr Mutation. J. Immunol. 161: 6427-6432 [Abstract] [Full Text]
Meyers, C. M., Tomaszewski, J. E., Glass, J. D., Chen, C. W. (1998). The Nephritogenic T Cell Response in Murine Chronic Graft-Versus-Host Disease. J. Immunol. 161: 5321-5330 [Abstract] [Full Text]
Theofilopoulos, A N (1998). Effector and predisposing genes in murine lupus. Lupus 7: 575-584 [Abstract]
Li, S., Kurts, C., Kontgen, F., Holdsworth, S. R., Tipping, P. G. (1998). Major Histocompatibility Complex Class II Expression by Intrinsic Renal Cells Is Required for Crescentic Glomerulonephritis. JEM 188: 597-602 [Abstract] [Full Text]
Schwarting, A., Wada, T., Kinoshita, K., Tesch, G., Rubin Kelley, V. (1998). IFN-{gamma} Receptor Signaling Is Essential for the Initiation, Acceleration, and Destruction of Autoimmune Kidney Disease in MRL-Faslpr Mice. J. Immunol. 161: 494-503 [Abstract] [Full Text]
Sobel, E. S., Kakkanaiah, V. N., Schiffenbauer, J., Reap, E. A., Cohen, P. L., Eisenberg, R. A. (1998). Novel Immunoregulatory B Cell Pathways Revealed by lpr-+ Mixed Chimeras. J. Immunol. 160: 1497-1503 [Abstract] [Full Text]
Peng, S. L., Moslehi, J., Robert, M. E., Craft, J. (1998). Perforin Protects Against Autoimmunity in Lupus-Prone Mice. J. Immunol. 160: 652-660 [Abstract] [Full Text]
Sobel, E.S. (1996). Cellular Interactions in the LPR and GLD Models of Systemic Autoimmunity. fake Adv Dent Res 10: 76-80 [Abstract]