Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo

doi:10.1084/jem.179.3.1059

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Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo

S Bogen, J Pak, M Garifallou, X Deng and WA Muller
Department of Pathology, Boston University School of Medicine, Massachusetts 02118-2394.

A murine model of peritonitis was used to test the role of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) in acute inflammation. A monoclonal antibody (mAb) specific for murine PECAM-1 injected intravenously 4 h before the intraperitoneal injection of thioglycollate broth blocked leukocyte emigration into the peritoneal cavity for up to 48 h. This block was particularly evident for neutrophils. Control mAb, including one that bound to murine CD18 without blocking its function, failed to block emigration when used at the same or higher concentrations. The decreased emigration seen with the anti-PECAM-1 antibody was not due to neutropenia or neutrophil sequestration in the lung, spleen, or other organs; peripheral blood leukocyte counts were not diminished in these mice. In the mesenteric venules of the mice treated with anti-PECAM-1 mAb, leukocytes were frequently seen in association with the luminal surface of the vessel, but did not appear to emigrate. Thus, the requirement for PECAM-1 in the transendothelial migration of leukocytes previously seen in an in vitro model holds true in this in vivo model of acute inflammation.
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Eugenin, E. A., Gamss, R., Buckner, C., Buono, D., Klein, R. S., Schoenbaum, E. E., Calderon, T. M., Berman, J. W. (2006). Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS.. J. Leukoc. Biol. 79: 444-452 [Abstract] [Full Text]
Corada, M., Chimenti, S., Cera, M. R., Vinci, M., Salio, M., Fiordaliso, F., De Angelis, N., Villa, A., Bossi, M., Staszewsky, L. I., Vecchi, A., Parazzoli, D., Motoike, T., Latini, R., Dejana, E. (2005). Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury. Proc. Natl. Acad. Sci. USA 102: 10634-10639 [Abstract] [Full Text]
Wang, S., Dangerfield, J. P., Young, R. E., Nourshargh, S. (2005). PECAM-1, {alpha}6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration. J. Cell Sci. 118: 2067-2076 [Abstract] [Full Text]
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Reymond, N., Imbert, A.-M., Devilard, E., Fabre, S., Chabannon, C., Xerri, L., Farnarier, C., Cantoni, C., Bottino, C., Moretta, A., Dubreuil, P., Lopez, M. (2004). DNAM-1 and PVR Regulate Monocyte Migration through Endothelial Junctions. JEM 199: 1331-1341 [Abstract] [Full Text]
van Buul, J. D., Hordijk, P. L. (2004). Signaling in Leukocyte Transendothelial Migration. Arterioscler. Thromb. Vasc. Bio. 24: 824-833 [Abstract] [Full Text]
Moog-Lutz, C., Cave-Riant, F., Guibal, F. C., Breau, M. A., Di Gioia, Y., Couraud, P. O., Cayre, Y. E., Bourdoulous, S., Lutz, P. G. (2003). JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood 102: 3371-3378 [Abstract] [Full Text]
Newman, P. J., Newman, D. K. (2003). Signal Transduction Pathways Mediated by PECAM-1: New Roles for an Old Molecule in Platelet and Vascular Cell Biology. Arterioscler. Thromb. Vasc. Bio. 23: 953-964 [Abstract] [Full Text]
O'Brien, C. D., Lim, P., Sun, J., Albelda, S. M. (2003). PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization. Blood 101: 2816-2825 [Abstract] [Full Text]
Tasaka, S., Qin, L., Saijo, A., Albelda, S. M., DeLisser, H. M., Doerschuk, C. M. (2003). Platelet Endothelial Cell Adhesion Molecule-1 in Neutrophil Emigration during Acute Bacterial Pneumonia in Mice and Rats. Am. J. Respir. Crit. Care Med. 167: 164-170 [Abstract] [Full Text]
Saito, H., Minamiya, Y., Saito, S., Ogawa, J.-i. (2002). Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation. J. Leukoc. Biol. 72: 829-836 [Abstract] [Full Text]
Khatri, S., Lass, J. H., Heinzel, F. P., Petroll, W. M., Gomez, J., Diaconu, E., Kalsow, C. M., Pearlman, E. (2002). Regulation of Endotoxin-Induced Keratitis by PECAM-1, MIP-2, and Toll-like Receptor 4. IOVS 43: 2278-2284 [Abstract] [Full Text]
Wong, M.-X., Roberts, D., Bartley, P. A., Jackson, D. E. (2002). Absence of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) Leads to Increased Severity of Local and Systemic IgE-Mediated Anaphylaxis and Modulation of Mast Cell Activation. J. Immunol. 168: 6455-6462 [Abstract] [Full Text]
Hamerman, J. A., Aderem, A. (2001). Functional Transitions in Macrophages During In Vivo Infection with Mycobacterium bovis Bacillus Calmette-Guerin. J. Immunol. 167: 2227-2233 [Abstract] [Full Text]
Miller, M., Sung, K.-L. P., Muller, W. A., Cho, J. Y., Roman, M., Castaneda, D., Nayar, J., Condon, T., Kim, J., Sriramarao, P., Broide, D. H. (2001). Eosinophil Tissue Recruitment to Sites of Allergic Inflammation in the Lung Is Platelet Endothelial Cell Adhesion Molecule Independent. J. Immunol. 167: 2292-2297 [Abstract] [Full Text]
RayChaudhury, A., Elkins, M., Kozien, D., Nakada, M. T. (2001). Regulation of PECAM-1 in Endothelial Cells during Cell Growth and Migration. Exp. Biol. Med. 226: 686-691 [Abstract] [Full Text]
Kaifi, J. T., Diaconu, E., Pearlman, E. (2001). Distinct Roles for PECAM-1, ICAM-1, and VCAM-1 in Recruitment of Neutrophils and Eosinophils to the Cornea in Ocular Onchocerciasis (River Blindness). J. Immunol. 166: 6795-6801 [Abstract] [Full Text]
Minagar, A., Jy, W., Jimenez, J. J., Sheremata, W. A., Mauro, L. M., Mao, W. W., Horstman, L. L., Ahn, Y. S. (2001). Elevated plasma endothelial microparticles in multiple sclerosis. Neurology 56: 1319-1324 [Abstract] [Full Text]
Patil, S., Newman, D. K., Newman, P. J. (2001). Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen. Blood 97: 1727-1732 [Abstract] [Full Text]
Thompson, R. D., Noble, K. E., Larbi, K. Y., Dewar, A., Duncan, G. S., Mak, T. W., Nourshargh, S. (2001). Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane. Blood 97: 1854-1860 [Abstract] [Full Text]
Srikrishna, G., Toomre, D. K., Manzi, A., Panneerselvam, K., Freeze, H. H., Varki, A., Varki, N. M. (2001). A Novel Anionic Modification of N-Glycans on Mammalian Endothelial Cells Is Recognized by Activated Neutrophils and Modulates Acute Inflammatory Responses. J. Immunol. 166: 624-632 [Abstract] [Full Text]
Bourdillon, M.-C., Poston, R. N., Covacho, C., Chignier, E., Bricca, G., McGregor, J. L. (2000). ICAM-1 Deficiency Reduces Atherosclerotic Lesions in Double-Knockout Mice (ApoE-/-/ICAM-1-/-) Fed a Fat or a Chow Diet. Arterioscler. Thromb. Vasc. Bio. 20: 2630-2635 [Abstract] [Full Text]
Zibara, K., Chignier, E., Covacho, C., Poston, R., Canard, G., Hardy, P., McGregor, J. (2000). Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet-Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E-Deficient Compared With Wild-Type Mice. Arterioscler. Thromb. Vasc. Bio. 20: 2288-2296 [Abstract] [Full Text]
Wagner, J. G., Roth, R. A. (2000). Neutrophil Migration Mechanisms, with an Emphasis on the Pulmonary Vasculature. Pharmacol. Rev. 52: 349-374 [Abstract] [Full Text]
Wang, S.-L., Kutsche, M., DiSciullo, G., Schachner, M., Bogen, S. A. (2000). Selective Malformation of the Splenic White Pulp Border in L1-Deficient Mice. J. Immunol. 165: 2465-2473 [Abstract] [Full Text]
Mahooti, S., Graesser, D., Patil, S., Newman, P., Duncan, G., Mak, T., Madri, J. A. (2000). PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo. Am. J. Pathol. 157: 75-81 [Abstract] [Full Text]
Thompson, R. D., Wakelin, M. W., Larbi, K. Y., Dewar, A., Asimakopoulos, G., Horton, M. A., Nakada, M. T., Nourshargh, S. (2000). Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and {beta}3 Integrin Blockade on Leukocyte Transmigration In Vivo. J. Immunol. 165: 426-434 [Abstract] [Full Text]
Nakada, M. T., Amin, K., Christofidou-Solomidou, M., O'Brien, C. D., Sun, J., Gurubhagavatula, I., Heavner, G. A., Taylor, A. H., Paddock, C., Sun, Q.-H., Zehnder, J. L., Newman, P. J., Albelda, S. M., DeLisser, H. M. (2000). Antibodies Against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block In Vivo Neutrophil Recruitment. J. Immunol. 164: 452-462 [Abstract] [Full Text]
Liao, F., Schenkel, A. R., Muller, W. A. (1999). Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes. J. Immunol. 163: 5640-5648 [Abstract] [Full Text]
Chiba, R., Nakagawa, N., Kurasawa, K., Tanaka, Y., Saito, Y., Iwamoto, I. (1999). Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells. Blood 94: 1319-1329 [Abstract] [Full Text]
Quarmby, S., Kumar, P., Wang, J., Macro, J. A., Hutchinson, J. J., Hunter, R. D., Kumar, S. (1999). Irradiation Induces Upregulation of CD31 in Human Endothelial Cells. Arterioscler. Thromb. Vasc. Bio. 19: 588-597 [Abstract] [Full Text]
Duncan, G. S., Andrew, D. P., Takimoto, H., Kaufman, S. A., Yoshida, H., Spellberg, J., Luis de la Pompa, J., Elia, A., Wakeham, A., Karan-Tamir, B., Muller, W. A., Senaldi, G., Zukowski, M. M., Mak, T. W. (1999). Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions. J. Immunol. 162: 3022-3030 [Abstract] [Full Text]
Ilan, N, Mahooti, S, Rimm, D., Madri, J. (1999). PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. J. Cell Sci. 112: 3005-3014 [Abstract]
Serebruany, V. L., Gurbel, P. A. (1999). Effect of Thrombolytic Therapy on Platelet Expression and Plasma Concentration of PECAM-1 (CD31) in Patients With Acute Myocardial Infarction. Arterioscler. Thromb. Vasc. Bio. 19: 153-158 [Abstract] [Full Text]
Wang, S.-Z., Smith, P. K., Lovejoy, M., Bowden, J. J., Alpers, J. H., Forsyth, K. D. (1998). Shedding of L-selectin and PECAM-1 and upregulation of Mac-1 and ICAM-1 on neutrophils in RSV bronchiolitis. Am. J. Physiol. Lung Cell. Mol. Physiol. 275: L983-L989 [Abstract] [Full Text]
Seino, K.-i., Iwabuchi, K., Kayagaki, N., Miyata, R., Nagaoka, I., Matsuzawa, A., Fukao, K., Yagita, H., Okumura, K. (1998). Cutting Edge: Chemotactic Activity of Soluble Fas Ligand Against Phagocytes. J. Immunol. 161: 4484-4488 [Abstract] [Full Text]
DeLisser, H. M., Albelda, S. M. (1998). The Function of Cell Adhesion Molecules in Lung Inflammation: More Questions Than Answers. Am. J. Respir. Cell Mol. Bio. 19: 533-536 [Full Text]
Saito, H., Minamiya, Y., Kitamura, M., Saito, S., Enomoto, K., Terada, K., Ogawa, J.-i. (1998). Endothelial Myosin Light Chain Kinase Regulates Neutrophil Migration Across Human Umbilical Vein Endothelial Cell Monolayer. J. Immunol. 161: 1533-1540 [Abstract] [Full Text]
Martin-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., Simmons, D., Dejana, E. (1998). Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration. JCB 142: 117-127 [Abstract] [Full Text]
Sun, Q.-H., Paddock, C., Visentin, G. P., Zukowski, M. M., Muller, W. A., Newman, P. J. (1998). Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1. PECAM-1 IS NOT A HEPARIN-BINDING PROTEIN. J. Biol. Chem. 273: 11483-11490 [Abstract] [Full Text]
Nakashima, Y., Raines, E. W., Plump, A. S., Breslow, J. L., Ross, R. (1998). Upregulation of VCAM-1 and ICAM-1 at Atherosclerosis-Prone Sites on the Endothelium in the ApoE-Deficient Mouse. Arterioscler. Thromb. Vasc. Bio. 18: 842-851 [Abstract] [Full Text]
Lu, B., Rutledge, B. J., Gu, L., Fiorillo, J., Lukacs, N. W., Kunkel, S. L., North, R., Gerard, C., Rollins, B. J. (1998). Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1-deficient Mice. JEM 187: 601-608 [Abstract] [Full Text]
Varon, D., Jackson, D. E., Shenkman, B., Dardik, R., Tamarin, I., Savion, N., Newman, P. J. (1998). Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets. Blood 91: 500-507 [Abstract] [Full Text]
Sagawa, K., Kimura, T., Swieter, M., Siraganian, R. P. (1997). The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31). J. Biol. Chem. 272: 31086-31091 [Abstract] [Full Text]
Famiglietti, J., Sun, J., DeLisser, H. M., Albelda, S. M. (1997). Tyrosine Residue in Exon 14�of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity. JCB 138: 1425-1435 [Abstract] [Full Text]
Sagawa, K., Swaim, W., Zhang, J., Unsworth, E., Siraganian, R. P. (1997). Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31). J. Biol. Chem. 272: 13412-13418 [Abstract] [Full Text]
Liao, F., Ali, J., Greene, T., Muller, W. A. (1997). Soluble Domain 1�of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo. JEM 185: 1349-1358 [Abstract] [Full Text]
Jackson, D. E., Ward, C. M., Wang, R., Newman, P. J. (1997). The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation. EVIDENCE FOR A MECHANISTIC LINK BETWEEN PECAM-1- AND INTEGRIN-MEDIATED CELLULAR SIGNALING. J. Biol. Chem. 272: 6986-6993 [Abstract] [Full Text]
Gumina, R. J., Kirschbaum, N. E., Piotrowski, K., Newman, P. J. (1997). Characterization of the Human Platelet/Endothelial Cell Adhesion Molecule-1 Promoter: Identification of a GATA-2 Binding Element Required for Optimal Transcriptional Activity. Blood 89: 1260-1269 [Abstract] [Full Text]
Gotsch, U, Borges, E, Bosse, R, Boggemeyer, E, Simon, M, Mossmann, H, Vestweber, D (1997). VE-cadherin antibody accelerates neutrophil recruitment in vivo. J. Cell Sci. 110: 583-588 [Abstract]
Gumina, R. J., Schultz, J. E., Yao, Z., Kenny, D., Warltier, D. C., Newman, P. J., Gross, G. J. (1996). Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury. Circulation 94: 3327-3333 [Abstract] [Full Text]
Sun, J., Williams, J., Yan, H.-C., Amin, K. M., Albelda, S. M., DeLisser, H. M. (1996). Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1and 2and Depends on the Cytoplasmic Domain and the Level of Surface Expression. J. Biol. Chem. 271: 18561-18570 [Abstract] [Full Text]
Sun, Q.-H., DeLisser, H. M., Zukowski, M. M., Paddock, C., Albelda, S. M., Newman, P. J. (1996). Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity. J. Biol. Chem. 271: 11090-11098 [Abstract] [Full Text]
Buckley, C., Doyonnas, R, Newton, J., Blystone, S., Brown, E., Watt, S., Simmons, D. (1996). Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1. J. Cell Sci. 109: 437-445 [Abstract]
Yan, H.-C., Baldwin, H. S., Sun, J., Buck, C. A., Albelda, S. M., DeLisser, H. M. (1995). Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1). J. Biol. Chem. 270: 23672-23680 [Abstract] [Full Text]
Cao, G., O'Brien, C. D., Zhou, Z., Sanders, S. M., Greenbaum, J. N., Makrigiannakis, A., DeLisser, H. M. (2002). Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration. Am. J. Physiol. Cell Physiol. 282: C1181-C1190 [Abstract] [Full Text]