Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide

doi:10.1084/jem.178.4.1435

This Article

Full Text (PDF, 1091K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Kamijo, R.

Articles by Vilcek, J.

Search for Related Content

PubMed

PubMed Citation

Articles by Kamijo, R.

Articles by Vilcek, J.

Pubmed/NCBI databases

Medline Plus Health Information
Gene	GEO Profiles
HomoloGene	UniGene
Compound via MeSH
Substance via MeSH
Tuberculosis

Social Bookmarking

What's this?

ARTICLES

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide

R Kamijo, J Le, D Shapiro, EA Havell, S Huang, M Aguet, M Bosland and J Vilcek
Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, New York 10016.

Mice with a targeted disruption of the interferon gamma receptor gene (IFN-gamma R0/0 mice) and control wild-type mice were inoculated with the Bacillus Calmette-Guerin (BCG) strain of Mycobacterium bovis. BCG infection was not lethal for wild-type mice whereas all IFN-gamma R0/0 mice died approximately 7-9 wk after inoculation. Histological examination at 2 and 6 wk after BCG inoculation showed that livers of IFN-gamma R0/0 mice had higher numbers of acid-fast bacteria than wild- type mice, especially at 6 wk. In parallel, the livers of IFN-gamma R0/0 mice showed a reduction in the formation of characteristic granulomas at 2 wk after inoculation. Injection of lipopolysaccharide (LPS) 2 wk after BCG inoculation was significantly less lethal for IFN- gamma R0/0 mice than for wild-type mice. Reduced lethality of LPS correlated with a drastically reduced production of tumor necrosis factor alpha (TNF-alpha) in the IFN-gamma R0/0 mice. Interleukin 1 alpha (IL-1 alpha) and IL-6 levels in the serum were also significantly reduced in the IFN-gamma R0/0 mice after BCG infection and LPS challenge. The greatly reduced capacity of BCG-infected IFN-gamma R0/0 mice to produce TNF-alpha may be an important factor in their inability to resist BCG infection. These results show that the presence of a functional IFN-gamma receptor is essential for the recovery of mice from BCG infection, and that IFN-gamma is a key element in the complex process whereby BCG infection leads to the sensitization to endotoxin.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Lee, J., Reinke, E. K., Zozulya, A. L., Sandor, M., Fabry, Z. (2008). Mycobacterium bovis Bacille Calmette-Guerin Infection in the CNS Suppresses Experimental Autoimmune Encephalomyelitis and Th17 Responses in an IFN-{gamma}-Independent Manner. J. Immunol. 181: 6201-6212 [Abstract] [Full Text]
Chiba, A., Dascher, C. C., Besra, G. S., Brenner, M. B. (2008). Rapid NKT Cell Responses Are Self-Terminating during the Course of Microbial Infection. J. Immunol. 181: 2292-2302 [Abstract] [Full Text]
Bokhari, S. M., Kim, K.-J., Pinson, D. M., Slusser, J., Yeh, H.-W., Parmely, M. J. (2008). NK Cells and Gamma Interferon Coordinate the Formation and Function of Hepatic Granulomas in Mice Infected with the Francisella tularensis Live Vaccine Strain. Infect. Immun. 76: 1379-1389 [Abstract] [Full Text]
Rottman, M., Catherinot, E., Hochedez, P., Emile, J.-F., Casanova, J.-L., Gaillard, J.-L., Soudais, C. (2007). Importance of T Cells, Gamma Interferon, and Tumor Necrosis Factor in Immune Control of the Rapid Grower Mycobacterium abscessus in C57BL/6 Mice. Infect. Immun. 75: 5898-5907 [Abstract] [Full Text]
Coelho, A. L., Schaller, M. A., Benjamim, C. F., Orlofsky, A. Z., Hogaboam, C. M., Kunkel, S. L. (2007). The Chemokine CCL6 Promotes Innate Immunity via Immune Cell Activation and Recruitment. J. Immunol. 179: 5474-5482 [Abstract] [Full Text]
Pandiyan, P., Hegel, J. K. E., Krueger, M., Quandt, D., Brunner-Weinzierl, M. C. (2007). High IFN-{gamma} Production of Individual CD8 T Lymphocytes Is Controlled by CD152 (CTLA-4). J. Immunol. 178: 2132-2140 [Abstract] [Full Text]
Catherinot, E., Clarissou, J., Etienne, G., Ripoll, F., Emile, J.-F., Daffe, M., Perronne, C., Soudais, C., Gaillard, J.-L., Rottman, M. (2007). Hypervirulence of a Rough Variant of the Mycobacterium abscessus Type Strain. Infect. Immun. 75: 1055-1058 [Abstract] [Full Text]
Loeuillet, C., Martinon, F., Perez, C., Munoz, M., Thome, M., Meylan, P. R. (2006). Mycobacterium tuberculosis Subverts Innate Immunity to Evade Specific Effectors. J. Immunol. 177: 6245-6255 [Abstract] [Full Text]
Ohteki, T., Tada, H., Ishida, K., Sato, T., Maki, C., Yamada, T., Hamuro, J., Koyasu, S. (2006). Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. JEM 203: 2329-2338 [Abstract] [Full Text]
Jeevan, A., McFarland, C. T., Yoshimura, T., Skwor, T., Cho, H., Lasco, T., McMurray, D. N. (2006). Production and Characterization of Guinea Pig Recombinant Gamma Interferon and Its Effect on Macrophage Activation. Infect. Immun. 74: 213-224 [Abstract] [Full Text]
Fukasawa, Y., Kawamura, I., Uchiyama, R., Yamamoto, K., Kaku, T., Tominaga, T., Nomura, T., Ichiyama, S., Ezaki, T., Mitsuyama, M. (2005). Streptomycin-Dependent Exhibition of Cytokine-Inducing Activity in Streptomycin-Dependent Mycobacterium tuberculosis Strain 18b. Infect. Immun. 73: 7051-7055 [Abstract] [Full Text]
Masaki, T., Chiba, S., Tatsukawa, H., Noguchi, H., Kakuma, T., Endo, M., Seike, M., Watanabe, T., Yoshimatsu, H. (2005). The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury. FASEB J. 19: 1245-1252 [Abstract] [Full Text]
Haring, J. S., Corbin, G. A., Harty, J. T. (2005). Dynamic Regulation of IFN-{gamma} Signaling in Antigen-Specific CD8+ T Cells Responding to Infection. J. Immunol. 174: 6791-6802 [Abstract] [Full Text]
Vinay, D. S., Choi, B. K., Bae, J. S., Kim, W. Y., Gebhardt, B. M., Kwon, B. S. (2004). CD137-Deficient Mice Have Reduced NK/NKT Cell Numbers and Function, Are Resistant to Lipopolysaccharide-Induced Shock Syndromes, and Have Lower IL-4 Responses. J. Immunol. 173: 4218-4229 [Abstract] [Full Text]
Fulton, S. A., Reba, S. M., Pai, R. K., Pennini, M., Torres, M., Harding, C. V., Boom, W. H. (2004). Inhibition of Major Histocompatibility Complex II Expression and Antigen Processing in Murine Alveolar Macrophages by Mycobacterium bovis BCG and the 19-Kilodalton Mycobacterial Lipoprotein. Infect. Immun. 72: 2101-2110 [Abstract] [Full Text]
Raju, B., Hoshino, Y., Kuwabara, K., Belitskaya, I., Prabhakar, S., Canova, A., Gold, J. A., Condos, R., Pine, R. I., Brown, S., Rom, W. N., Weiden, M. D. (2004). Aerosolized Gamma Interferon (IFN-{gamma}) Induces Expression of the Genes Encoding the IFN-{gamma}-Inducible 10-Kilodalton Protein but Not Inducible Nitric Oxide Synthase in the Lung during Tuberculosis. Infect. Immun. 72: 1275-1283 [Abstract] [Full Text]
Schroder, K., Hertzog, P. J., Ravasi, T., Hume, D. A. (2004). Interferon-{gamma}: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75: 163-189 [Abstract] [Full Text]
Segel, M. J., Izbicki, G., Cohen, P. Y., Or, R., Christensen, T. G., Wallach-Dayan, S. B., Breuer, R. (2003). Role of interferon-{gamma} in the evolution of murine bleomycin lung fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L1255-L1262 [Abstract] [Full Text]
Villarreal-Ramos, B., McAulay, M., Chance, V., Martin, M., Morgan, J., Howard, C. J. (2003). Investigation of the Role of CD8+ T Cells in Bovine Tuberculosis In Vivo. Infect. Immun. 71: 4297-4303 [Abstract] [Full Text]
Weyand, C. M., Goronzy, J. J. (2003). Medium- and Large-Vessel Vasculitis. NEJM 349: 160-169 [Full Text]
Zhang, G., Nichols, R. D., Taniguchi, M., Nakayama, T., Parmely, M. J. (2003). Gamma Interferon Production by Hepatic NK T Cells during Escherichia coli Infection Is Resistant to the Inhibitory Effects of Oxidative Stress. Infect. Immun. 71: 2468-2477 [Abstract] [Full Text]
Condos, R., Raju, B., Canova, A., Zhao, B.-Y., Weiden, M., Rom, W. N., Pine, R. (2003). Recombinant Gamma Interferon Stimulates Signal Transduction and Gene Expression in Alveolar Macrophages In Vitro and in Tuberculosis Patients. Infect. Immun. 71: 2058-2064 [Abstract] [Full Text]
Jeevan, A., Yoshimura, T., Lee, K. E., McMurray, D. N. (2003). Differential Expression of Gamma Interferon mRNA Induced by Attenuated and Virulent Mycobacterium tuberculosis in Guinea Pig Cells after Mycobacterium bovis BCG Vaccination. Infect. Immun. 71: 354-364 [Abstract] [Full Text]
Sisto, F., Miluzio, A., Leopardi, O., Mirra, M., Boelaert, J. R., Taramelli, D. (2003). Differential Cytokine Pattern in the Spleens and Livers of BALB/c Mice Infected with Penicillium marneffei: Protective Role of Gamma Interferon. Infect. Immun. 71: 465-473 [Abstract] [Full Text]
Biet, F., Kremer, L., Wolowczuk, I., Delacre, M., Locht, C. (2002). Mycobacterium bovis BCG Producing Interleukin-18 Increases Antigen-Specific Gamma Interferon Production in Mice. Infect. Immun. 70: 6549-6557 [Abstract] [Full Text]
Takada, H., Yokoyama, S., Shuhua Yang, (2002). Mini-review: Enhancement of endotoxin activity by muramyldipeptide. Innate Immunity 8: 337-342 [Abstract]
Abel, B., Thieblemont, N., Quesniaux, V. J. F., Brown, N., Mpagi, J., Miyake, K., Bihl, F., Ryffel, B. (2002). Toll-Like Receptor 4 Expression Is Required to Control Chronic Mycobacterium tuberculosis Infection in Mice. J. Immunol. 169: 3155-3162 [Abstract] [Full Text]
Plotnicky-Gilquin, H., Cyblat-Chanal, D., Aubry, J.-P., Champion, T., Beck, A., Nguyen, T., Bonnefoy, J.-Y., Corvaia, N. (2002). Gamma Interferon-Dependent Protection of the Mouse Upper Respiratory Tract following Parenteral Immunization with a Respiratory Syncytial Virus G Protein Fragment. J. Virol. 76: 10203-10210 [Abstract] [Full Text]
Joshi, V. D., Kalvakolanu, D. V., Hasday, J. D., Hebel, R. J., Cross, A. S. (2002). IL-18 Levels and the Outcome of Innate Immune Response to Lipopolysaccharide: Importance of a Positive Feedback Loop with Caspase-1 in IL-18 Expression. J. Immunol. 169: 2536-2544 [Abstract] [Full Text]
Erb, K. J., Trujillo, C., Fugate, M., Moll, H. (2002). Infection with the Helminth Nippostrongylus brasiliensis Does Not Interfere with Efficient Elimination of Mycobacterium bovis BCG from the Lungs of Mice. CVI 9: 727-730 [Abstract] [Full Text]
Olleros, M. L., Guler, R., Corazza, N., Vesin, D., Eugster, H.-P., Marchal, G., Chavarot, P., Mueller, C., Garcia, I. (2002). Transmembrane TNF Induces an Efficient Cell-Mediated Immunity and Resistance to Mycobacterium bovis Bacillus Calmette-Guerin Infection in the Absence of Secreted TNF and Lymphotoxin-{alpha}. J. Immunol. 168: 3394-3401 [Abstract] [Full Text]
Holscher, C., Atkinson, R. A., Arendse, B., Brown, N., Myburgh, E., Alber, G., Brombacher, F. (2001). A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection. J. Immunol. 167: 6957-6966 [Abstract] [Full Text]
Billiau, A., Matthys, P. (2001). Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J. Leukoc. Biol. 70: 849-860 [Abstract] [Full Text]
Wiedermann, C. J., Kiechl, S., Schratzberger, P., Dunzendorfer, S., Weiss, G., Willeit, J. (2001). The role of immune activation in endotoxin-induced atherogenesis. Innate Immunity 7: 322-326 [Abstract]
Dupuis, S., Dargemont, C., Fieschi, C., Thomassin, N., Rosenzweig, S., Harris, J., Holland, S. M., Schreiber, R. D., Casanova, J.-L. (2001). Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation. Science 293: 300-303 [Abstract] [Full Text]
Boechat, N., Bouchonnet, F., Bonay, M., Grodet, A., Pelicic, V., Gicquel, B., Hance, A. J. (2001). Culture at High Density Improves the Ability of Human Macrophages to Control Mycobacterial Growth. J. Immunol. 166: 6203-6211 [Abstract] [Full Text]
Hogan, L. H., Macvilay, K., Barger, B., Co, D., Malkovska, I., Fennelly, G., Sandor, M. (2001). Mycobacterium bovis Strain Bacillus Calmette-Guerin-Induced Liver Granulomas Contain a Diverse TCR Repertoire, but a Monoclonal T Cell Population Is Sufficient for Protective Granuloma Formation. J. Immunol. 166: 6367-6375 [Abstract] [Full Text]
Hogan, L. H., Markofski, W., Bock, A., Barger, B., Morrissey, J. D., Sandor, M. (2001). Mycobacterium bovis BCG-Induced Granuloma Formation Depends on Gamma Interferon and CD40 Ligand but Does Not Require CD28. Infect. Immun. 69: 2596-2603 [Abstract] [Full Text]
Parmely, M. J., Wang, F., Wright, D. (2001). Gamma Interferon Prevents the Inhibitory Effects of Oxidative Stress on Host Responses to Escherichia coli Infection. Infect. Immun. 69: 2621-2629 [Abstract] [Full Text]
Merlin, T., Gumenscheimer, M., Galanos, C., Freudenberg, M. A. (2001). TNF-{alpha} hyper-responses to Gram-negative and Gram-positive bacteria in Propionibacterium acnes primed or Salmonella typhimurium infected mice. Innate Immunity 7: 157-163 [Abstract]
Halloran, P. F., Afrouzian, M., Ramassar, V., Urmson, J., Zhu, L.-F., Helms, L. M. H., Solez, K., Kneteman, N. M. (2001). Interferon-{{gamma}} Acts Directly on Rejecting Renal Allografts to Prevent Graft Necrosis. Am. J. Pathol. 158: 215-226 [Abstract] [Full Text]
Su, Z., Stevenson, M. M. (2000). Central Role of Endogenous Gamma Interferon in Protective Immunity against Blood-Stage Plasmodium chabaudi AS Infection. Infect. Immun. 68: 4399-4406 [Abstract] [Full Text]
Hochholzer, P., Lipford, G. B., Wagner, H., Pfeffer, K., Heeg, K. (2000). Role of Interleukin-18 (IL-18) during Lethal Shock: Decreased Lipopolysaccharide Sensitivity but Normal Superantigen Reaction in IL-18-Deficient Mice. Infect. Immun. 68: 3502-3508 [Abstract] [Full Text]
Liu, Q.-P., Fruit, K., Ward, J., Correll, P. H. (1999). Negative Regulation of Macrophage Activation in Response to IFN-{gamma} and Lipopolysaccharide by the STK/RON Receptor Tyrosine Kinase. J. Immunol. 163: 6606-6613 [Abstract] [Full Text]
Bhattacharyya, S., Singla, R., Dey, A. B., Prasad, H. K. (1999). Dichotomy of Cytokine Profiles in Patients and High-Risk Healthy Subjects Exposed to Tuberculosis. Infect. Immun. 67: 5597-5603 [Abstract] [Full Text]
Freudenberg, M. A., Merlin, T., Gumenscheimer, M., Sing, A., Galanos, C. (1999). Bacteria-induced hypersensitivity to endotoxin. Innate Immunity 5: 231-238 [Abstract]
Murray, P. J., Young, R. A. (1999). Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice. Infect. Immun. 67: 3087-3095 [Abstract] [Full Text]
MOHAMMED, K.�A., NASREEN, N., WARD, M.�J., ANTONY, V.�B. (1999). Helper T Cell Type 1�and 2�Cytokines Regulate C-C Chemokine Expression in Mouse Pleural Mesothelial Cells. Am. J. Respir. Crit. Care Med. 159: 1653-1659 [Abstract] [Full Text]
Sempowski, G. D., Lee, D. M., Scearce, R. M., Patel, D. D., Haynes, B. F. (1999). Resistance of CD7-deficient Mice to Lipopolysaccharide-induced Shock Syndromes. JEM 189: 1011-1016 [Abstract] [Full Text]
Sakao, Y., Takeda, K., Tsutsui, H., Kaisho, T., Nomura, F., Okamura, H., Nakanishi, K., Akira, S. (1999). IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock. Int Immunol 11: 471-480 [Abstract] [Full Text]
Hagiwara, S.-I., Takeya, M., Suzuki, H., Kodama, T., van der Laan, L. J. W., Kraal, G., Kitamura, N., Takahashi, K. (1999). Role of Macrophage Scavenger Receptors in Hepatic Granuloma Formation in Mice. Am. J. Pathol. 154: 705-720 [Abstract] [Full Text]
Dellacasagrande, J., Capo, C., Raoult, D., Mege, J.-L. (1999). IFN-{gamma}-Mediated Control of Coxiella burnetii Survival in Monocytes: The Role of Cell Apoptosis and TNF. J. Immunol. 162: 2259-2265 [Abstract] [Full Text]
Held, T. K., Weihua, X., Yuan, L., Kalvakolanu, D. V., Cross, A. S. (1999). Gamma Interferon Augments Macrophage Activation by Lipopolysaccharide by Two Distinct Mechanisms, at the Signal Transduction Level and via an Autocrine Mechanism Involving Tumor Necrosis Factor Alpha and Interleukin-1. Infect. Immun. 67: 206-212 [Abstract] [Full Text]
Facchetti, F., Vermi, W., Fiorentini, S., Chilosi, M., Caruso, A., Duse, M., Notarangelo, L. D., Badolato, R. (1999). Expression of Inducible Nitric Oxide Synthase in Human Granulomas and Histiocytic Reactions. Am. J. Pathol. 154: 145-152 [Abstract] [Full Text]
Bellamy, R. (1998). Genetics and pulmonary medicine bullet �3: Genetic susceptibility to tuberculosis in human populations. Thorax 53: 588-593 [Full Text]
ASTON, C., ROM, W.�N., TALBOT, A.�T., REIBMAN, J. (1998). Early Inhibition of Mycobacterial Growth by Human Alveolar Macrophages is not Due to Nitric Oxide. Am. J. Respir. Crit. Care Med. 157: 1943-1950 [Abstract] [Full Text]
Yoshimoto, T., Takahama, Y., Wang, C.-R., Yoneto, T., Waki, S., Nariuchi, H. (1998). A Pathogenic Role of IL-12 in Blood-Stage Murine Malaria Lethal Strain Plasmodium berghei NK65 Infection. J. Immunol. 160: 5500-5505 [Abstract] [Full Text]
Bohn, E., Schmitt, E., Bielfeldt, C., Noll, A., Schulte, R., Autenrieth, I. B. (1998). Ambiguous Role of Interleukin-12 in Yersinia enterocolitica Infection in Susceptible and Resistant Mouse Strains. Infect. Immun. 66: 2213-2220 [Abstract] [Full Text]
Murray, P. J., Young, R. A., Daley, G. Q. (1998). Hematopoietic Remodeling in Interferon-gamma -Deficient Mice Infected With Mycobacteria. Blood 91: 2914-2924 [Abstract] [Full Text]
SCHLUGER, N.�W., ROM, W.�N. (1998). The Host Immune Response to Tuberculosis. Am. J. Respir. Crit. Care Med. 157: 679-691 [Full Text]
Dickensheets, H. L., Freeman, S. L., Smith Jr, M. F., Donnelly, R. P. (1997). Interleukin-10 Upregulates Tumor Necrosis Factor Receptor Type-II (p75) Gene Expression in Endotoxin-Stimulated Human Monocytes. Blood 90: 4162-4171 [Abstract] [Full Text]
Haworth, R., Platt, N., Keshav, S., Hughes, D., Darley, E., Suzuki, H., Kurihara, Y., Kodama, T., Gordon, S. (1997). The Macrophage Scavenger Receptor Type A Is Expressed by Activated Macrophages and Protects the Host Against Lethal Endotoxic Shock. JEM 186: 1431-1439 [Abstract] [Full Text]
MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., Nathan, C. F. (1997). Identification of nitric oxide synthase as a protective locus against�tuberculosis. Proc. Natl. Acad. Sci. USA 94: 5243-5248 [Abstract] [Full Text]
Young, H. A., Klinman, D. M., Reynolds, D. A., Grzegorzewski, K. J., Nii, A., Ward, J. M., Winkler-Pickett, R. T., Ortaldo, J. R., Kenny, J. J., Komschlies, K. L. (1997). Bone Marrow and Thymus Expression of Interferon-gamma Results in Severe B-Cell Lineage Reduction, T-Cell Lineage Alterations, and Hematopoietic Progenitor Deficiencies. Blood 89: 583-595 [Abstract] [Full Text]
Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R., Levin, M. (1996). A Mutation in the Interferon-{gamma} -Receptor Gene and Susceptibility to Mycobacterial Infection. NEJM 335: 1941-1949 [Abstract] [Full Text]
Jouanguy, E., Altare, F., Lamhamedi, S., Revy, P., Emile, J.-F., Newport, M., Levin, M., Blanche, S., Seboun, E., Fischer, A., Casanova, J.-L. (1996). Interferon-{gamma} -Receptor Deficiency in an Infant with Fatal Bacille Calmette-Guerin Infection. NEJM 335: 1956-1962 [Full Text]
Kamijo, R, Harada, H, Matsuyama, T, Bosland, M, Gerecitano, J, Shapiro, D, Le, J, Koh, S., Kimura, T, Green, S., et, al. (1994). Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263: 1612-1615 [Abstract]