Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology

doi:10.1084/jem.178.2.675

This Article

	Full Text (PDF, 535K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Buck, J.
	Articles by Hammerling, U.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Buck, J.
	Articles by Hammerling, U.


Social Bookmarking

	What's this?

ARTICLES

Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology

J Buck, F Grun, F Derguini, Y Chen, S Kimura, N Noy and U Hammerling
Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York 10021.

Vitamin A (retinol) is an essential cofactor for growth of B lymphocytes in culture and for activation of T lymphocytes by antigen receptor-mediated signals. 14-hydroxy-4,14-retro-retinol (14-HRR) a metabolite of retinol, has been implicated as the intracellular mediator of this effect. Anhydroretinol (AR) is a retinol derivative with retro structure produced in activated human B lymphocytes and the insect cell lines SF 21 and Schneider S2. AR reversibly inhibits retinol- and 14-HRR-dependent effects and blocks B lymphocyte proliferation as well as activation of resting T lymphocytes. The intracellular signaling pathway blocked by AR in T cell activation is distinct from the calcineurin/interleukin 2 pathway inhibitable by cyclosporine A or FK-506.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Chiu, H.-J., Fischman, D. A., Hammerling, U. (2008). Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation. FASEB J. 22: 3878-3887 [Abstract] [Full Text]
Moise, A. R., Kuksa, V., Blaner, W. S., Baehr, W., Palczewski, K. (2005). Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid. J. Biol. Chem. 280: 27815-27825 [Abstract] [Full Text]
Hoyos, B., Jiang, S., Hammerling, U. (2005). Location and Functional Significance of Retinol-binding Sites on the Serine/Threonine Kinase, c-Raf. J. Biol. Chem. 280: 6872-6878 [Abstract] [Full Text]
Moise, A. R., Kuksa, V., Imanishi, Y., Palczewski, K. (2004). Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase. J. Biol. Chem. 279: 50230-50242 [Abstract] [Full Text]
Brunner, C., Laumen, H., Nielsen, P. J., Kraut, N., Wirth, T. (2003). Expression of the Aldehyde Dehydrogenase 2-like Gene Is Controlled by BOB.1/OBF.1 in B Lymphocytes. J. Biol. Chem. 278: 45231-45239 [Abstract] [Full Text]
Tabb, M. M., Sun, A., Zhou, C., Grun, F., Errandi, J., Romero, K., Pham, H., Inoue, S., Mallick, S., Lin, M., Forman, B. M., Blumberg, B. (2003). Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR. J. Biol. Chem. 278: 43919-43927 [Abstract] [Full Text]
Korichneva, I., Waka, J., Hammerling, U. (2003). Regulation of the Cardiac Mitochondrial Membrane Potential by Retinoids. J. Pharmacol. Exp. Ther. 305: 426-433 [Abstract] [Full Text]
Grun, F., Venkatesan, R. N., Tabb, M. M., Zhou, C., Cao, J., Hemmati, D., Blumberg, B. (2002). Benzoate X Receptors alpha and beta Are Pharmacologically Distinct and Do Not Function as Xenobiotic Receptors. J. Biol. Chem. 277: 43691-43697 [Abstract] [Full Text]
Hoyos, B., Imam, A., Korichneva, I., Levi, E., Chua, R., Hammerling, U. (2002). Activation of c-Raf Kinase by Ultraviolet Light. REGULATION BY RETINOIDS. J. Biol. Chem. 277: 23949-23957 [Abstract] [Full Text]
Guo, X., Nanus, D. M, Ruiz, A., Rando, R. R, Bok, D., Gudas, L. J (2001). Reduced Levels of Retinyl Esters and Vitamin A in Human Renal Cancers. Cancer Res. 61: 2774-2781 [Abstract] [Full Text]
Guo, X., Ruiz, A., Rando, R. R., Bok, D., Gudas, L. J. (2000). Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines. Carcinogenesis 21: 1925-1933 [Abstract] [Full Text]
, , , , , , , , , , , , , , , (2000). The Cysteine-rich Regions of the Regulatory Domains of Raf and Protein Kinase C as Retinoid. JEM 192: 835-846 [Abstract] [Full Text]
Chen, Y., Buck, J. (2000). Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism. J. Pharmacol. Exp. Ther. 293: 807-812 [Abstract] [Full Text]
Lane, M. A., Chen, A. C., Roman, S. D., Derguini, F., Gudas, L. J. (1999). Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells. Proc. Natl. Acad. Sci. USA 96: 13524-13529 [Abstract] [Full Text]
Naderi, S., Blomhoff, H. K. (1999). Retinoic Acid Prevents Phosphorylation of pRB in Normal Human B Lymphocytes: Regulation of Cyclin E, Cyclin A, and p21Cip1. Blood 94: 1348-1358 [Abstract] [Full Text]
Chen, Y., Buck, J., Derguini, F. (1999). Anhydroretinol Induces Oxidative Stress and Cell Death. Cancer Res. 59: 3985-3990 [Abstract] [Full Text]
Korichneva, I, Hammerling, U (1999). F-actin as a functional target for retro-retinoids: a potential role in anhydroretinol-triggered cell death. J. Cell Sci. 112: 2521-2528 [Abstract]
Vakiani, E., Luz, J. G., Buck, J. (1998). Substrate Specificity and Kinetic Mechanism of the Insect Sulfotransferase, Retinol Dehydratase. J. Biol. Chem. 273: 35381-35387 [Abstract] [Full Text]
Chen, Y., Derguini, F., Buck, J. (1997). Vitamin A in serum is a survival factor for�fibroblasts. Proc. Natl. Acad. Sci. USA 94: 10205-10208 [Abstract] [Full Text]
Grun, F., Noy, N., Hammerling, U., Buck, J. (1996). Purification, Cloning, and Bacterial Expression of Retinol Dehydratase from Spodoptera frugiperda. J. Biol. Chem. 271: 16135-16138 [Abstract] [Full Text]
Missbach, M., Jagher, B., Sigg, I., Nayeri, S., Carlberg, C., Wiesenberg, I. (1996). Thiazolidine Diones, Specific Ligands of the Nuclear Receptor Retinoid Z Receptor/Retinoid Acid Receptor-related Orphan Receptor alpha with Potent Antiarthritic Activity. J. Biol. Chem. 271: 13515-13522 [Abstract] [Full Text]
Derguini, F., Nakanishi, K., H�mmerling, U., Chua, R., Eppinger, T., Levi, E., Buck, J. (1995). 13,14-Dihydroxy-retinol, a New Bioactive Retinol Metabolite. J. Biol. Chem. 270: 18875-18880 [Abstract] [Full Text]