CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40

doi:10.1084/jem.178.2.669

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CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40

MR Alderson, RJ Armitage, TW Tough, L Strockbine, WC Fanslow and MK Spriggs
Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101.

CD40 is a member of the tumor necrosis factor (TNF) receptor family of cell surface proteins and was originally described as a B cell restricted antigen. Treatment of primary human monocytes with granulocyte/macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3), or interferon gamma (IFN-gamma) resulted in the induction of CD40 mRNA and enhancement of cell surface protein expression. CD40 was found to mediate monocyte adhesion to cells expressing recombinant CD40 ligand. CD40 ligand-transfected cells provided a potent costimulus for monocyte TNF-alpha and IL-6 production in the presence of GM-CSF, IL-3, or IFN-gamma, and enhanced IL-8 production stimulated by GM-CSF or IL- 3. In addition, CD40 ligand-transfected cells acting in the absence of a costimulus induced monocytes to become tumoricidal against a human melanoma cell target. Collectively, these data indicate that CD40 ligand is pleiotropic with potent biological activity on monocytes.
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Imaizumi, K., Kawabe, T., Ichiyama, S., Kikutani, H., Yagita, H., Shimokata, K., Hasegawa, Y. (1999). Enhancement of tumoricidal activity of alveolar macrophages via CD40-CD40 ligand interaction. Am. J. Physiol. Lung Cell. Mol. Physiol. 277: L49-L57 [Abstract] [Full Text]
Tarte, K., Zhang, X.-G., Legouffe, E., Hertog, C., Mehtali, M., Rossi, J.-F., Klein, B. (1999). Induced Expression of B7-1 on Myeloma Cells Following Retroviral Gene Transfer Results in Tumor-Specific Recognition by Cytotoxic T Cells. J. Immunol. 163: 514-524 [Abstract] [Full Text]
Subauste, C. S., Wessendarp, M., Sorensen, R. U., Leiva, L. E. (1999). CD40-CD40 Ligand Interaction Is Central to Cell-Mediated Immunity Against Toxoplasma gondii: Patients with Hyper IgM Syndrome Have a Defective Type 1 Immune Response That Can Be Restored by Soluble CD40 Ligand Trimer. J. Immunol. 162: 6690-6700 [Abstract] [Full Text]
BONAY, M., BOUCHONNET, F., PELICIC, V., LAGIER, B., GRANDSAIGNE, M., LECOSSIER, D., GRODET, A., VOKURKA, M., GICQUEL, B., HANCE, A.�J. (1999). Effect of Stimulation of Human Macrophages on Intracellular Survival of Mycobacterium bovis Bacillus Calmette-Guerin . Evaluation with a Mycobacterial Reporter Strain. Am. J. Respir. Crit. Care Med. 159: 1629-1637 [Abstract] [Full Text]
Hirano, A., Longo, D. L., Taub, D. D., Ferris, D. K., Young, L. S., Eliopoulos, A. G., Agathanggelou, A., Cullen, N., Macartney, J., Fanslow, W. C., Murphy, W. J. (1999). Inhibition of Human Breast Carcinoma Growth by a Soluble Recombinant Human CD40 Ligand. Blood 93: 2999-3007 [Abstract] [Full Text]
Altenburg, A., Baldus, S. E., Smola, H., Pfister, H., Hess, S. (1999). CD40 Ligand-CD40 Interaction Induces Chemokines in Cervical Carcinoma Cells in Synergism with IFN-{gamma}. J. Immunol. 162: 4140-4147 [Abstract] [Full Text]
Wiley, J. A., Harmsen, A. G. (1999). Bone Marrow-Derived Cells Are Required for the Induction of a Pulmonary Inflammatory Response Mediated by CD40 Ligation. Am. J. Pathol. 154: 919-926 [Abstract] [Full Text]
Suttles, J., Milhorn, D. M., Miller, R. W., Poe, J. C., Wahl, L. M., Stout, R. D. (1999). CD40 Signaling of Monocyte Inflammatory Cytokine Synthesis through an ERK1/2-dependent Pathway. A TARGET OF INTERLEUKIN ()-4 AND IL-10 ANTI-INFLAMMATORY ACTION. J. Biol. Chem. 274: 5835-5842 [Abstract] [Full Text]
Maxwell, J. R., Campbell, J. D., Kim, C. H., Vella, A. T. (1999). CD40 Activation Boosts T Cell Immunity In Vivo by Enhancing T Cell Clonal Expansion and Delaying Peripheral T Cell Deletion. J. Immunol. 162: 2024-2034 [Abstract] [Full Text]
De Milito, A., Nagy, N., Samuelsson, A., Chiodi, F., Rajnavolgyi, E. (1998). Nerve Growth Factor Released by CD40 Ligand-Transfected L Cells: Implications for Functional and Phenotypic Studies on CD40+ Cells. Blood 92: 4482-4484 [Full Text]
Craxton, A., Shu, G., Graves, J. D., Saklatvala, J., Krebs, E. G., Clark, E. A. (1998). p38 MAPK Is Required for CD40-Induced Gene Expression and Proliferation in B Lymphocytes. J. Immunol. 161: 3225-3236 [Abstract] [Full Text]
Avice, M.-N., Demeure, C. E., Delespesse, G., Rubio, M., Armant, M., Sarfati, M. (1998). IL-15 Promotes IL-12 Production by Human Monocytes Via T Cell-Dependent Contact and May Contribute to IL-12-Mediated IFN-{gamma} Secretion by CD4+ T Cells in the Absence of TCR Ligation. J. Immunol. 161: 3408-3415 [Abstract] [Full Text]
Lazaar, A. L., Amrani, Y., Hsu, J., Panettieri, R. A. Jr., Fanslow, W. C., Albelda, S. M., Pure, E. (1998). CD40-Mediated Signal Transduction in Human Airway Smooth Muscle. J. Immunol. 161: 3120-3127 [Abstract] [Full Text]
Nakajima, A., Kodama, T., Morimoto, S., Azuma, M., Takeda, K., Oshima, H., Yoshino, S.-i., Yagita, H., Okumura, K. (1998). Antitumor Effect of CD40 Ligand: Elicitation of Local and Systemic Antitumor Responses by IL-12 and B7. J. Immunol. 161: 1901-1907 [Abstract] [Full Text]
Kornbluth, R. S., Kee, K., Richman, D. D. (1998). CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta -chemokines. Proc. Natl. Acad. Sci. USA 95: 5205-5210 [Abstract] [Full Text]
Campos-Neto, A., Ovendale, P., Bement, T., Koppi, T. A., Fanslow, W. C., Rossi, M. A., Alderson, M. R. (1998). Cutting Edge: CD40 Ligand Is Not Essential for the Development of Cell-Mediated Immunity and Resistance to Mycobacterium tuberculosis. J. Immunol. 160: 2037-2041 [Abstract] [Full Text]
Kalled, S. L., Cutler, A. H., Datta, S. K., Thomas, D. W. (1998). Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function. J. Immunol. 160: 2158-2165 [Abstract] [Full Text]
Silver, R. F., Li, Q., Boom, W. H., Ellner, J. J. (1998). Lymphocyte-Dependent Inhibition of Growth of Virulent Mycobacterium tuberculosis H37Rv Within Human Monocytes: Requirement for CD4+ T Cells in Purified Protein Derivative-Positive, But Not in Purified Protein Derivative-Negative Subjects. J. Immunol. 160: 2408-2417 [Abstract] [Full Text]
McDyer, J. F., Goletz, T. J., Thomas, E., June, C. H., Seder, R. A. (1998). CD40 Ligand/CD40 Stimulation Regulates the Production of IFN-{gamma} from Human Peripheral Blood Mononuclear Cells in an IL-12- and/or CD28-Dependent Manner. J. Immunol. 160: 1701-1707 [Abstract] [Full Text]