PECAM-1 is required for transendothelial migration of leukocytes

doi:10.1084/jem.178.2.449

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PECAM-1 is required for transendothelial migration of leukocytes

WA Muller, SA Weigl, X Deng and DM Phillips
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York.

Platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) is crucial to the process of leukocyte transmigration through intercellular junctions of vascular endothelial cells. A monoclonal antibody to PECAM, or recombinant soluble PECAM, blocks transendothelial migration of monocytes by 70-90%. Pretreating either the monocytes or the endothelial junctions with antibody blocks transmigration. If the endothelium is first activated by cytokines, anti-PECAM antibody or soluble recombinant PECAM again block transmigration of both monocytes and neutrophils. Anti-PECAM does not block chemotaxis of either cell type. Light and electron microscopy reveal that leukocytes blocked in transmigration remain tightly bound to the apical surface of the endothelial cell, precisely over the intercellular junction. Thus, the process of leukocyte emigration can be dissected into three successive stages: rolling, mediated by the selectin class of adhesion molecules; tight adhesion, mediated by the leukocyte integrins and their endothelial cell counter-receptors; and now transmigration, which, based on these studies, requires PECAM-1.
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Downey, D G, Bell, S C, Elborn, J S (2009). Neutrophils in cystic fibrosis. Thorax 64: 81-88 [Abstract] [Full Text]
Guo, Y.-L., Bai, R., Chen, C. X-J, Liu, D.-Q., Liu, Y., Zhang, C.-Y., Zen, K. (2009). Role of Junctional Adhesion Molecule-Like Protein in Mediating Monocyte Transendothelial Migration. Arterioscler. Thromb. Vasc. Bio. 29: 75-83 [Abstract] [Full Text]
Nottebaum, A. F., Cagna, G., Winderlich, M., Gamp, A. C., Linnepe, R., Polaschegg, C., Filippova, K., Lyck, R., Engelhardt, B., Kamenyeva, O., Bixel, M. G., Butz, S., Vestweber, D. (2008). VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. JEM 205: 2929-2945 [Abstract] [Full Text]
Ali, S., Jenkins, Y., Kirkley, M., Dagkalis, A., Manivannan, A., Crane, I. J., Kirby, J. A. (2008). Leukocyte Extravasation: An Immunoregulatory Role for {alpha}-L-Fucosidase?. J. Immunol. 181: 2407-2413 [Abstract] [Full Text]
van Wanrooij, E. J.A., de Vos, P., Bixel, M. G., Vestweber, D., van Berkel, T. J.C., Kuiper, J. (2008). Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice. Cardiovasc Res 78: 590-596 [Abstract] [Full Text]
Bergom, C., Paddock, C., Gao, C., Holyst, T., Newman, D. K., Newman, P. J. (2008). An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling. J. Cell Sci. 121: 1235-1242 [Abstract] [Full Text]
Mamdouh, Z., Kreitzer, G. E., Muller, W. A. (2008). Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment. JEM 205: 951-966 [Abstract] [Full Text]
Garnacho, C., Shuvaev, V., Thomas, A., McKenna, L., Sun, J., Koval, M., Albelda, S., Muzykantov, V., Muro, S. (2008). RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood 111: 3024-3033 [Abstract] [Full Text]
Woodfin, A., Voisin, M.-B., Nourshargh, S. (2007). PECAM-1: A Multi-Functional Molecule in Inflammation and Vascular Biology. Arterioscler. Thromb. Vasc. Bio. 27: 2514-2523 [Abstract] [Full Text]
Nakhaei-Nejad, M., Hussain, A. M., Zhang, Q.-X., Murray, A. G. (2007). Endothelial PI 3-kinase activity regulates lymphocyte diapedesis. Am. J. Physiol. Heart Circ. Physiol. 293: H3608-H3616 [Abstract] [Full Text]
Vernon-Wilson, E. F., Aurade, F., Tian, L., Rowe, I. C. M., Shipston, M. J., Savill, J., Brown, S. B. (2007). CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells. J. Leukoc. Biol. 82: 1278-1288 [Abstract] [Full Text]
Gallay, N., Anani, L., Lopez, A., Colombat, P., Binet, C., Domenech, J., Weksler, B. B., Malavasi, F., Herault, O. (2007). The Role of Platelet/Endothelial Cell Adhesion Molecule 1 (CD31) and CD38 Antigens in Marrow Microenvironmental Retention of Acute Myelogenous Leukemia Cells. Cancer Res. 67: 8624-8632 [Abstract] [Full Text]
Woodfin, A., Reichel, C. A., Khandoga, A., Corada, M., Voisin, M.-B., Scheiermann, C., Haskard, D. O., Dejana, E., Krombach, F., Nourshargh, S. (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood 110: 1848-1856 [Abstract] [Full Text]
Matsutani, T., Tanaka, T., Tohya, K., Otani, K., Jang, M. H., Umemoto, E., Taniguchi, K., Hayasaka, H., Ueda, K., Miyasaka, M. (2007). Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells molecular basis of their trafficking to lymph nodes. Int Immunol 0: dxm088v1-dxm088 [Abstract] [Full Text]
Dahlbacka, S., Alaoja, H., Makela, J., Niemela, E., Laurila, P., Kiviluoma, K., Honkanen, A., Ohtonen, P., Anttila, V., Juvonen, T. (2007). Effects of pH Management During Selective Antegrade Cerebral Perfusion on Cerebral Microcirculation and Metabolism: Alpha-Stat Versus pH-Stat. Ann. Thorac. Surg. 84: 847-855 [Abstract] [Full Text]
Sachs, U. J. H., Andrei-Selmer, C. L., Maniar, A., Weiss, T., Paddock, C., Orlova, V. V., Choi, E. Y., Newman, P. J., Preissner, K. T., Chavakis, T., Santoso, S. (2007). The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31). J. Biol. Chem. 282: 23603-23612 [Abstract] [Full Text]
Wang, C. Q.F., Cheng, C. Y. (2007). A seamless trespass: germ cell migration across the seminiferous epithelium during spermatogenesis. JCB 178: 549-556 [Abstract] [Full Text]
Rao, R. M., Yang, L., Garcia-Cardena, G., Luscinskas, F. W. (2007). Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall. Circ. Res. 101: 234-247 [Abstract] [Full Text]
Rijcken, E., Mennigen, R. B., Schaefer, S. D., Laukoetter, M. G., Anthoni, C., Spiegel, H.-U., Bruewer, M., Senninger, N., Krieglstein, C. F. (2007). PECAM-1 (CD 31) mediates transendothelial leukocyte migration in experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G446-G452 [Abstract] [Full Text]
Brown, S. B., Tucker, C. S., Ford, C., Lee, Y., Dunbar, D. R., Mullins, J. J. (2007). Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish. J. Leukoc. Biol. 82: 79-84 [Abstract] [Full Text]
Bixel, M. G., Petri, B., Khandoga, A. G., Khandoga, A., Wolburg-Buchholz, K., Wolburg, H., Marz, S., Krombach, F., Vestweber, D. (2007). A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Blood 109: 5327-5336 [Abstract] [Full Text]
Kelly, K. A., Allport, J. R., Yu, A. M., Sinh, S., Sage, E. H., Gerszten, R. E., Weissleder, R. (2007). SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration. J. Leukoc. Biol. 81: 748-756 [Abstract] [Full Text]
Lou, O., Alcaide, P., Luscinskas, F. W., Muller, W. A. (2007). CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils. J. Immunol. 178: 1136-1143 [Abstract] [Full Text]
Ortolan, E., Tibaldi, E. V., Ferranti, B., Lavagno, L., Garbarino, G., Notaro, R., Luzzatto, L., Malavasi, F., Funaro, A. (2006). CD157 plays a pivotal role in neutrophil transendothelial migration. Blood 108: 4214-4222 [Abstract] [Full Text]
Alaoja, H., Niemela, E., Anttila, V., Dahlbacka, S., Makela, J., Kiviluoma, K., Laurila, P., Kaakinen, T., Juvonen, T. (2006). Leukocyte filtration to decrease the number of adherent leukocytes in the cerebral microcirculation after a period of deep hypothermic circulatory arrest. J. Thorac. Cardiovasc. Surg. 132: 1339-1347 [Abstract] [Full Text]
Viegas, P., Chaverot, N., Enslen, H., Perriere, N., Couraud, P.-O., Cazaubon, S. (2006). Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes. J. Cell Sci. 119: 4634-4643 [Abstract] [Full Text]
Imbert, A.-M., Belaaloui, G., Bardin, F., Tonnelle, C., Lopez, M., Chabannon, C. (2006). CD99 expressed on human mobilized peripheral blood CD34+ cells is involved in transendothelial migration. Blood 108: 2578-2586 [Abstract] [Full Text]
Kumar, S., Jack, R. (2006). Invited review: Origin of monocytes and their differentiation to macrophages and dendritic cells. Innate Immunity 12: 278-284 [Abstract]
Nourshargh, S., Krombach, F., Dejana, E. (2006). The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues. J. Leukoc. Biol. 80: 714-718 [Abstract] [Full Text]
Vestweber, D. (2006). ICAM-2 and PECAM-1: 2 steps in leukocyte transmigration. Blood 107: 4579-4580 [Full Text]
Wang, S., Voisin, M.-B., Larbi, K. Y., Dangerfield, J., Scheiermann, C., Tran, M., Maxwell, P. H., Sorokin, L., Nourshargh, S. (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. JEM 203: 1519-1532 [Abstract] [Full Text]
Vernon-Wilson, E. F., Aurade, F., Brown, S. B. (2006). CD31 promotes {beta}1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin. J. Leukoc. Biol. 79: 1260-1267 [Abstract] [Full Text]
Cernuda-Morollon, E., Ridley, A. J. (2006). Rho GTPases and Leukocyte Adhesion Receptor Expression and Function in Endothelial Cells. Circ. Res. 98: 757-767 [Abstract] [Full Text]
Yun, P. L. W., DeCarlo, A. A., Hunter, N. (2006). Gingipains of Porphyromonas gingivalis Modulate Leukocyte Adhesion Molecule Expression Induced in Human Endothelial Cells by Ligation of CD99. Infect. Immun. 74: 1661-1672 [Abstract] [Full Text]
Eugenin, E. A., Gamss, R., Buckner, C., Buono, D., Klein, R. S., Schoenbaum, E. E., Calderon, T. M., Berman, J. W. (2006). Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS.. J. Leukoc. Biol. 79: 444-452 [Abstract] [Full Text]
Brevetti, G., Schiano, V., Chiariello, M. (2006). Cellular adhesion molecules and peripheral arterial disease. Vasc Med 11: 39-47 [Abstract]
Galkina, E., Ley, K. (2006). Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy. J. Am. Soc. Nephrol. 17: 368-377 [Abstract] [Full Text]
Falati, S., Patil, S., Gross, P. L., Stapleton, M., Merrill-Skoloff, G., Barrett, N. E., Pixton, K. L., Weiler, H., Cooley, B., Newman, D. K., Newman, P. J., Furie, B. C., Furie, B., Gibbins, J. M. (2006). Platelet PECAM-1 inhibits thrombus formation in vivo. Blood 107: 535-541 [Abstract] [Full Text]
Aurrand-Lions, M., Lamagna, C., Dangerfield, J. P., Wang, S., Herrera, P., Nourshargh, S., Imhof, B. A. (2005). Junctional Adhesion Molecule-C Regulates the Early Influx of Leukocytes into Tissues during Inflammation. J. Immunol. 174: 6406-6415 [Abstract] [Full Text]
Wang, S., Dangerfield, J. P., Young, R. E., Nourshargh, S. (2005). PECAM-1, {alpha}6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration. J. Cell Sci. 118: 2067-2076 [Abstract] [Full Text]
Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M. C., Vadas, M. A., Gamble, J. R. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood 105: 3169-3177 [Abstract] [Full Text]
Ostermann, G., Fraemohs, L., Baltus, T., Schober, A., Lietz, M., Zernecke, A., Liehn, E. A., Weber, C. (2005). Involvement of JAM-A in Mononuclear Cell Recruitment on Inflamed or Atherosclerotic Endothelium: Inhibition by Soluble JAM-A. Arterioscler. Thromb. Vasc. Bio. 25: 729-735 [Abstract] [Full Text]
Barreiro, O., Yanez-Mo, M., Sala-Valdes, M., Gutierrez-Lopez, M. D., Ovalle, S., Higginbottom, A., Monk, P. N., Cabanas, C., Sanchez-Madrid, F. (2005). Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation. Blood 105: 2852-2861 [Abstract] [Full Text]
Yun, P. L. W., Decarlo, A. A., Chapple, C. C., Hunter, N. (2005). Functional Implication of the Hydrolysis of Platelet Endothelial Cell Adhesion Molecule 1 (CD31) by Gingipains of Porphyromonas gingivalis for the Pathology of Periodontal Disease. Infect. Immun. 73: 1386-1398 [Abstract] [Full Text]
Yonekawa, K., Harlan, J. M. (2005). Targeting leukocyte integrins in human diseases. J. Leukoc. Biol. 77: 129-140 [Abstract] [Full Text]
Chavakis, E., Aicher, A., Heeschen, C., Sasaki, K.-i., Kaiser, R., El Makhfi, N., Urbich, C., Peters, T., Scharffetter-Kochanek, K., Zeiher, A. M., Chavakis, T., Dimmeler, S. (2005). Role of {beta}2-integrins for homing and neovascularization capacity of endothelial progenitor cells. JEM 201: 63-72 [Abstract] [Full Text]
Carrithers, M., Tandon, S., Canosa, S., Michaud, M., Graesser, D., Madri, J. A. (2005). Enhanced Susceptibility to Endotoxic Shock and Impaired STAT3 Signaling in CD31-Deficient Mice. Am. J. Pathol. 166: 185-196 [Abstract] [Full Text]
Salmi, M., Koskinen, K., Henttinen, T., Elima, K., Jalkanen, S. (2004). CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Blood 104: 3849-3857 [Abstract] [Full Text]
Schenkel, A. R., Chew, T. W., Muller, W. A. (2004). Platelet Endothelial Cell Adhesion Molecule Deficiency or Blockade Significantly Reduces Leukocyte Emigration in a Majority of Mouse Strains. J. Immunol. 173: 6403-6408 [Abstract] [Full Text]
Baumann, C. I., Bailey, A. S., Li, W., Ferkowicz, M. J., Yoder, M. C., Fleming, W. H. (2004). PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood 104: 1010-1016 [Abstract] [Full Text]
Chen, Y.-F., Tsai, W.-C., Lin, C.-C., Tsai, L.-Y., Lee, C.-S., Huang, C.-H., Pan, P.-C., Chen, M.-L. (2004). Effect of leukocyte depletion on endothelial cell activation and transendothelial migration of leukocytes during cardiopulmonary bypass. Ann. Thorac. Surg. 78: 634-642 [Abstract] [Full Text]
Albelda, S. M., Lau, K. C., Chien, P., Huang, Z.-Y., Arguiris, E., Bohen, A., Sun, J., Billet, J. A., Christofidou-Solomidou, M., Indik, Z. K., Schreiber, A. D. (2004). Role for Platelet-Endothelial Cell Adhesion Molecule-1 in Macrophage Fc{gamma} Receptor Function. Am. J. Respir. Cell Mol. Bio. 31: 246-255 [Abstract] [Full Text]
Reymond, N., Imbert, A.-M., Devilard, E., Fabre, S., Chabannon, C., Xerri, L., Farnarier, C., Cantoni, C., Bottino, C., Moretta, A., Dubreuil, P., Lopez, M. (2004). DNAM-1 and PVR Regulate Monocyte Migration through Endothelial Junctions. JEM 199: 1331-1341 [Abstract] [Full Text]
van Buul, J. D., Hordijk, P. L. (2004). Signaling in Leukocyte Transendothelial Migration. Arterioscler. Thromb. Vasc. Bio. 24: 824-833 [Abstract] [Full Text]
Furusawa, T., Ohkoshi, K., Honda, C., Takahashi, S., Tokunaga, T. (2004). Embryonic Stem Cells Expressing Both Platelet Endothelial Cell Adhesion Molecule-1 and Stage-Specific Embryonic Antigen-1 Differentiate Predominantly into Epiblast Cells in a Chimeric Embryo. Biol. Reprod. 70: 1452-1457 [Abstract] [Full Text]
Koskinen, K., Vainio, P. J., Smith, D. J., Pihlavisto, M., Yla-Herttuala, S., Jalkanen, S., Salmi, M. (2004). Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1). Blood 103: 3388-3395 [Abstract] [Full Text]
Swenson, S., Costa, F., Minea, R., Sherwin, R. P., Ernst, W., Fujii, G., Yang, D., Markland, F. S. Jr. (2004). Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression. Molecular Cancer Therapeutics 3: 499-511 [Abstract] [Full Text]
Vinten-Johansen, J. (2004). Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 61: 481-497 [Abstract] [Full Text]
Feng, D., Nagy, J. A., Pyne, K., Dvorak, H. F., Dvorak, A. M. (2004). Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium. J. Histochem. Cytochem. 52: 87-102 [Abstract] [Full Text]
Park, J., Choi, K.-S., Grab, D. J., Dumler, J. S. (2003). Divergent Interactions of Ehrlichia chaffeensis- and Anaplasma phagocytophilum-Infected Leukocytes with Endothelial Cell Barriers. Infect. Immun. 71: 6728-6733 [Abstract] [Full Text]
Stein, B. N., Gamble, J. R., Pitson, S. M., Vadas, M. A., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. J. Immunol. 171: 6097-6104 [Abstract] [Full Text]
Moog-Lutz, C., Cave-Riant, F., Guibal, F. C., Breau, M. A., Di Gioia, Y., Couraud, P. O., Cayre, Y. E., Bourdoulous, S., Lutz, P. G. (2003). JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood 102: 3371-3378 [Abstract] [Full Text]
Mohan, K., Pinto, D., Issekutz, T. B. (2003). Identification of Tissue Transglutaminase as a Novel Molecule Involved In Human CD8+ T Cell Transendothelial Migration. J. Immunol. 171: 3179-3186 [Abstract] [Full Text]
Gao, C., Sun, W., Christofidou-Solomidou, M., Sawada, M., Newman, D. K., Bergom, C., Albelda, S. M., Matsuyama, S., Newman, P. J. (2003). PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. Blood 102: 169-179 [Abstract] [Full Text]
Newman, P. J., Newman, D. K. (2003). Signal Transduction Pathways Mediated by PECAM-1: New Roles for an Old Molecule in Platelet and Vascular Cell Biology. Arterioscler. Thromb. Vasc. Bio. 23: 953-964 [Abstract] [Full Text]
Burns, A. R., Smith, C. W., Walker, D. C. (2003). Unique Structural Features That Influence Neutrophil Emigration Into the Lung. Physiol. Rev. 83: 309-336 [Abstract] [Full Text]
Righi, L., Deaglio, S., Pecchioni, C., Gregorini, A., Horenstein, A. L., Bussolati, G., Sapino, A., Malavasi, F. (2003). Role of CD31/Platelet Endothelial Cell Adhesion Molecule-1 Expression in in Vitro and in Vivo Growth and Differentiation of Human Breast Cancer Cells. Am. J. Pathol. 162: 1163-1174 [Abstract] [Full Text]
O'Brien, C. D., Lim, P., Sun, J., Albelda, S. M. (2003). PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization. Blood 101: 2816-2825 [Abstract] [Full Text]
Kobayashi, S. D., Voyich, J. M., Braughton, K. R., DeLeo, F. R. (2003). Down-Regulation of Proinflammatory Capacity During Apoptosis in Human Polymorphonuclear Leukocytes. J. Immunol. 170: 3357-3368 [Abstract] [Full Text]
Solowiej, A., Biswas, P., Graesser, D., Madri, J. A. (2003). Lack of Platelet Endothelial Cell Adhesion Molecule-1 Attenuates Foreign Body Inflammation because of Decreased Angiogenesis. Am. J. Pathol. 162: 953-962 [Abstract] [Full Text]
Tasaka, S., Qin, L., Saijo, A., Albelda, S. M., DeLisser, H. M., Doerschuk, C. M. (2003). Platelet Endothelial Cell Adhesion Molecule-1 in Neutrophil Emigration during Acute Bacterial Pneumonia in Mice and Rats. Am. J. Respir. Crit. Care Med. 167: 164-170 [Abstract] [Full Text]
Su, W.-H., Chen, H.-i., Jen, C. J. (2002). Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium. Blood 100: 3597-3603 [Abstract] [Full Text]
Dangerfield, J., Larbi, K. Y., Huang, M.-T., Dewar, A., Nourshargh, S. (2002). PECAM-1 (CD31) Homophilic Interaction Up-Regulates {alpha}6{beta}1 on Transmigrated Neutrophils In Vivo and Plays a Functional Role in the Ability of {alpha}6 Integrins to Mediate Leukocyte Migration through the Perivascular Basement Membrane. JEM 196: 1201-1212 [Abstract] [Full Text]
Weis, M., Schlichting, C. L., Engleman, E. G., Cooke, J. P. (2002). Endothelial Determinants of Dendritic Cell Adhesion and Migration: New Implications for Vascular Diseases. Arterioscler. Thromb. Vasc. Bio. 22: 1817-1823 [Abstract] [Full Text]
Johnson-Leger, C. A., Aurrand-Lions, M., Beltraminelli, N., Fasel, N., Imhof, B. A. (2002). Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood 100: 2479-2486 [Abstract] [Full Text]
Shuhaiber, J. H., Evans, A. N., Massad, M. G., Geha, A. S. (2002). Mechanisms and future directions for prevention of vein graft failure in coronary bypass surgery. Eur. J. Cardiothorac. Surg. 22: 387-396 [Abstract] [Full Text]
Preffer, F. I., Dombkowski, D., Sykes, M., Scadden, D., Yang, Y.-G. (2002). Lineage-Negative Side-Population (SP) Cells with Restricted Hematopoietic Capacity Circulate in Normal Human Adult Blood: Immunophenotypic and Functional Characterization. Stem Cells 20: 417-427 [Abstract] [Full Text]
Osawa, M., Masuda, M., Kusano, K.-i., Fujiwara, K. (2002). Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?. JCB 158: 773-785 [Abstract] [Full Text]
Mayer, K., Merfels, M., Muhly-Reinholz, M., Gokorsch, S., Rosseau, S., Lohmeyer, J., Schwarzer, N., Krull, M., Suttorp, N., Grimminger, F., Seeger, W. (2002). omega -3 Fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. Am. J. Physiol. Heart Circ. Physiol. 283: H811-H818 [Abstract] [Full Text]
Khatri, S., Lass, J. H., Heinzel, F. P., Petroll, W. M., Gomez, J., Diaconu, E., Kalsow, C. M., Pearlman, E. (2002). Regulation of Endotoxin-Induced Keratitis by PECAM-1, MIP-2, and Toll-like Receptor 4. IOVS 43: 2278-2284 [Abstract] [Full Text]
Wong, M.-X., Roberts, D., Bartley, P. A., Jackson, D. E. (2002). Absence of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) Leads to Increased Severity of Local and Systemic IgE-Mediated Anaphylaxis and Modulation of Mast Cell Activation. J. Immunol. 168: 6455-6462 [Abstract] [Full Text]
Broide, D. (2002). Fast Flowing Eosinophils . Signals for Stopping and Stepping Out of Blood Vessels. Am. J. Respir. Cell Mol. Bio. 26: 637-640 [Full Text]
Wiewrodt, R., Thomas, A. P., Cipelletti, L., Christofidou-Solomidou, M., Weitz, D. A., Feinstein, S. I., Schaffer, D., Albelda, S. M., Koval, M., Muzykantov, V. R. (2002). Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells. Blood 99: 912-922 [Abstract] [Full Text]
Nelissen, I., Ronsse, I., Van Damme, J., Opdenakker, G. (2002). Regulation of gelatinase B in human monocytic and endothelial cells by PECAM-1 ligation and its modulation by interferon-beta. J. Leukoc. Biol. 71: 89-98 [Abstract] [Full Text]
Cicmil, M., Thomas, J. M., Leduc, M., Bon, C., Gibbins, J. M. (2002). Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. Blood 99: 137-144 [Abstract] [Full Text]
Dobrina, A., Pausa, M., Fischetti, F., Bulla, R., Vecile, E., Ferrero, E., Mantovani, A., Tedesco, F. (2002). Cytolytically inactive terminal complement complex causes transendothelial migration of polymorphonuclear leukocytes in vitro and in vivo. Blood 99: 185-192 [Abstract] [Full Text]
Shaw, S. K., Perkins, B. N., Lim, Y.-C., Liu, Y., Nusrat, A., Schnell, F. J., Parkos, C. A., Luscinskas, F. W. (2001). Reduced Expression of Junctional Adhesion Molecule and Platelet/Endothelial Cell Adhesion Molecule-1 (CD31) at Human Vascular Endothelial Junctions by Cytokines Tumor Necrosis Factor-{alpha} Plus Interferon-{gamma} Does Not Reduce Leukocyte Transmigration Under Flow. Am. J. Pathol. 159: 2281-2291 [Abstract] [Full Text]
Liu, Y., Merlin, D., Burst, S. L., Pochet, M., Madara, J. L., Parkos, C. A. (2001). The Role of CD47 in Neutrophil Transmigration. INCREASED RATE OF MIGRATION CORRELATES WITH INCREASED CELL SURFACE EXPRESSION OF CD47. J. Biol. Chem. 276: 40156-40166 [Abstract] [Full Text]
Voura, E. B., Ramjeesingh, R. A., Montgomery, A. M.P., Siu, C.-H. (2001). Involvement of Integrin alpha vbeta 3 and Cell Adhesion Molecule L1 in Transendothelial Migration of Melanoma Cells. Mol. Biol. Cell 12: 2699-2710 [Abstract] [Full Text]
Miller, M., Sung, K.-L. P., Muller, W. A., Cho, J. Y., Roman, M., Castaneda, D., Nayar, J., Condon, T., Kim, J., Sriramarao, P., Broide, D. H. (2001). Eosinophil Tissue Recruitment to Sites of Allergic Inflammation in the Lung Is Platelet Endothelial Cell Adhesion Molecule Independent. J. Immunol. 167: 2292-2297 [Abstract] [Full Text]
RayChaudhury, A., Elkins, M., Kozien, D., Nakada, M. T. (2001). Regulation of PECAM-1 in Endothelial Cells during Cell Growth and Migration. Exp. Biol. Med. 226: 686-691 [Abstract] [Full Text]