Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules

doi:10.1084/jem.178.1.367

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Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules

RF Bargatze and EC Butcher
Department of Pathology, Stanford University School of Medicine, California 94305.

The homing of blood borne lymphocytes into lymph nodes and Peyer's patches is mediated in part by recognition and binding to specialized high endothelial venules (HEV). Here we demonstrate that a rapid pertussis toxin-sensitive lymphocyte activation event can participate in lymphocyte recognition of HEV. In situ video microscopic analyses of lymphocyte interactions with HEV in exteriorized mouse Peyer's patches reveal that pertussis toxin has no effect on an initial "rolling" displayed by many lymphocytes, but inhibits an activation-dependent "sticking" event required for lymphocyte arrest. This is the first demonstration that physiologic lymphocyte-endothelial interactions can involve sequential rolling, activation, and activation-dependent arrest, previously shown only for neutrophils. The inhibitory effect of the toxin is dependent on its G protein-modifying ADP- ribosyltransferase activity and can be reversed by phorbol myristic acetate, which bypasses cell surface receptors to trigger activation- dependent adhesion. Lymphocyte sticking can occur within 1-3 s after initiation of rolling. We conclude that a rapid receptor-mediated activation event involving G protein signaling can trigger stable lymphocyte attachment to HEV in vivo, and may play a critical role in regulating lymphocyte homing.
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Broide, D. (2002). Fast Flowing Eosinophils . Signals for Stopping and Stepping Out of Blood Vessels. Am. J. Respir. Cell Mol. Bio. 26: 637-640 [Full Text]
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Su, S. B., Silver, P. B., Zhang, M., Chan, C.-C., Caspi, R. R. (2001). Pertussis Toxin Inhibits Induction of Tissue-Specific Autoimmune Disease by Disrupting G Protein-Coupled Signals. J. Immunol. 167: 250-256 [Abstract] [Full Text]
Cinamon, G., Grabovsky, V., Winter, E., Franitza, S., Feigelson, S., Shamri, R., Dwir, O., Alon, R. (2001). Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow. J. Leukoc. Biol. 69: 860-866 [Abstract] [Full Text]
Zernecke, A., Weber, K. S. C., Erwig, L. P., Kluth, D. C., Schroppel, B., Rees, A. J., Weber, C. (2001). Combinatorial Model of Chemokine Involvement in Glomerular Monocyte Recruitment: Role of CXC Chemokine Receptor 2 in Infiltration During Nephrotoxic Nephritis. J. Immunol. 166: 5755-5762 [Abstract] [Full Text]
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von Andrian, U. H., Mackay, C. R. (2000). T-Cell Function and Migration -- Two Sides of the Same Coin. NEJM 343: 1020-1034 [Full Text]
Jinquan, T., Quan, S., Jacobi, H. H., Jing, C., Millner, A., Jensen, B., Madsen, H. O., Ryder, L. P., Svejgaard, A., Malling, H.-J., Skov, P. S., Poulsen, L. K. (2000). CXC chemokine receptor 3 expression on CD34+ hematopoietic progenitors from human cord blood induced by granulocyte-macrophage colony-stimulating factor: chemotaxis and adhesion induced by its ligands, interferon gamma -inducible protein 10 and monokine induced by interferon gamma. Blood 96: 1230-1238 [Abstract] [Full Text]
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Drillenburg, P., Pals, S. T. (2000). Cell adhesion receptors in lymphoma dissemination. Blood 95: 1900-1910 [Abstract] [Full Text]
Fong, A. M., Erickson, H. P., Zachariah, J. P., Poon, S., Schamberg, N. J., Imai, T., Patel, D. D. (2000). Ultrastructure and Function of the Fractalkine Mucin Domain in CX3C Chemokine Domain Presentation. J. Biol. Chem. 275: 3781-3786 [Abstract] [Full Text]
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Zabel, B. A., Agace, W. W., Campbell, J. J., Heath, H. M., Parent, D., Roberts, A. I., Ebert, E. C., Kassam, N., Qin, S., Zovko, M., LaRosa, G. J., Yang, L.-L., Soler, D., Butcher, E. C., Ponath, P. D., Parker, C. M., Andrew, D. P. (1999). Human G Protein-coupled Receptor GPR-9-6/CC Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-expressed Chemokine-mediated Chemotaxis. JEM 190: 1241-1256 [Abstract] [Full Text]
Mukai, S., Kjargaard, J., Shu, S., Plautz, G. E. (1999). Infiltration of Tumors by Systemically Transferred Tumor-Reactive T Lymphocytes Is Required for Antitumor Efficacy. Cancer Res. 59: 5245-5249 [Abstract] [Full Text]
Rabin, R. L., Park, M. K., Liao, F., Swofford, R., Stephany, D., Farber, J. M. (1999). Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling. J. Immunol. 162: 3840-3850 [Abstract] [Full Text]
Kawashima, H., Li, Y.-F., Watanabe, N., Hirose, J., Hirose, M., Miyasaka, M. (1999). Identification and characterization of ligands for L-selectin in the kidney. I. Versican, a large chondroitin sulfate proteoglycan, is a ligand for L-selectin. Int Immunol 11: 393-405 [Abstract] [Full Text]
Beadling, C., Druey, K. M., Richter, G., Kehrl, J. H., Smith, K. A. (1999). Regulators of G Protein Signaling Exhibit Distinct Patterns of Gene Expression and Target G Protein Specificity in Human Lymphocytes. J. Immunol. 162: 2677-2682 [Abstract] [Full Text]
Schenkel, A. R., Uno, H., Pauza, C. D. (1999). Asymptomatic Simian Immunodeficiency Virus Infection Decreases Blood CD4+ T Cells by Accumulating Recirculating Lymphocytes in the Lymphoid Tissues. J. Virol. 73: 601-607 [Abstract] [Full Text]
Miller, L. A., Butcher, E. C. (1998). Human Airway Epithelial Monolayers Promote Selective Transmigration of Memory T Cells: A Transepithelial Model of Lymphocyte Migration into the Airways. Am. J. Respir. Cell Mol. Bio. 19: 892-900 [Abstract] [Full Text]
Tangemann, K., Gunn, M. D., Giblin, P., Rosen, S. D. (1998). A High Endothelial Cell-Derived Chemokine Induces Rapid, Efficient, and Subset-Selective Arrest of Rolling T Lymphocytes on a Reconstituted Endothelial Substrate. J. Immunol. 161: 6330-6337 [Abstract] [Full Text]
Tedla, N., Wang, H.-W., McNeil, H. P., Di Girolamo, N., Hampartzoumian, T., Wakefield, D., Lloyd, A. (1998). Regulation of T Lymphocyte Trafficking into Lymph Nodes During an Immune Response by the Chemokines Macrophage Inflammatory Protein (MIP)-1{alpha} and MIP-1{beta}. J. Immunol. 161: 5663-5672 [Abstract] [Full Text]
Laudanna, C., Mochly-Rosen, D., Liron, T., Constantin, G., Butcher, E. C. (1998). Evidence of zeta �Protein Kinase C Involvement in Polymorphonuclear Neutrophil Integrin-dependent Adhesion and Chemotaxis. J. Biol. Chem. 273: 30306-30315 [Abstract] [Full Text]
Andrew, D. P., Chang, M.-s., McNinch, J., Wathen, S. T., Rihanek, M., Tseng, J., Spellberg, J. P., Elias, C. G. III (1998). STCP-1 (MDC) CC Chemokine Acts Specifically on Chronically Activated Th2 Lymphocytes and Is Produced by Monocytes on Stimulation with Th2 Cytokines IL-4 and IL-13. J. Immunol. 161: 5027-5038 [Abstract] [Full Text]
Bowman, E. P., Campbell, J. J., Druey, K. M., Scheschonka, A., Kehrl, J. H., Butcher, E. C. (1998). Regulation of Chemotactic and Proadhesive Responses to Chemoattractant Receptors by RGS (Regulator of G-protein Signaling) Family Members. J. Biol. Chem. 273: 28040-28048 [Abstract] [Full Text]
Fong, A. M., Robinson, L. A., Steeber, D. A., Tedder, T. F., Yoshie, O., Imai, T., Patel, D. D. (1998). Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow. JEM 188: 1413-1419 [Abstract] [Full Text]
Shaw, S. K., Hermanowski-Vosatka, A., Shibahara, T., McCormick, B. A., Parkos, C. A., Carlson, S. L., Ebert, E. C., Brenner, M. B., Madara, J. L. (1998). Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer. Am. J. Physiol. Gastrointest. Liver Physiol. 275: G584-G591 [Abstract] [Full Text]
Kunkel, E. J., Ramos, C. L., Steeber, D. A., Muller, W., Wagner, N., Tedder, T. F., Ley, K. (1998). The Roles of L-Selectin, {beta}7 Integrins, and P-Selectin in Leukocyte Rolling and Adhesion in High Endothelial Venules of Peyer's Patches. J. Immunol. 161: 2449-2456 [Abstract] [Full Text]
Pachynski, R. K., Wu, S. W., Gunn, M. D., Erle, D. J. (1998). Secondary Lymphoid-Tissue Chemokine (SLC) Stimulates Integrin {alpha}4{beta}7-Mediated Adhesion of Lymphocytes to Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) Under Flow. J. Immunol. 161: 952-956 [Abstract] [Full Text]
Ngo, V. N., Lucy Tang, H., Cyster, J. G. (1998). Epstein-Barr Virus-induced Molecule 1�Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells. JEM 188: 181-191 [Abstract] [Full Text]
Nakano, H., Mori, S., Yonekawa, H., Nariuchi, H., Matsuzawa, A., Kakiuchi, T. (1998). A Novel Mutant Gene Involved in T-Lymphocyte-Specific Homing Into Peripheral Lymphoid Organs on Mouse Chromosome 4�. Blood 91: 2886-2895 [Abstract] [Full Text]
Yoshida, R., Nagira, M., Kitaura, M., Imagawa, N., Imai, T., Yoshie, O. (1998). Secondary Lymphoid-tissue Chemokine Is a Functional Ligand for the CC Chemokine Receptor CCR7. J. Biol. Chem. 273: 7118-7122 [Abstract] [Full Text]
Clark, R. A., Fuhlbrigge, R. C., Springer, T. A. (1998). L-Selectin Ligands That Are O-glycoprotease Resistant and Distinct from MECA-79 Antigen are Sufficient for Tethering and Rolling of Lymphocytes on Human High Endothelial Venules. JCB 140: 721-731 [Abstract] [Full Text]
Newton, R. A., Hogg, N. (1998). The Human S100 Protein MRP-14 Is a Novel Activator of the {beta}2 Integrin Mac-1 on Neutrophils. J. Immunol. 160: 1427-1435 [Abstract] [Full Text]
Warnock, R. A., Askari, S., Butcher, E. C., Andrian, U. H.�v. (1998). Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes. JEM 187: 205-216 [Abstract] [Full Text]
Campbell, J. J., Hedrick, J., Zlotnik, A., Siani, M. A., Thompson, D. A., Butcher, E. C. (1998). Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions. Science 279: 381-384 [Abstract] [Full Text]
Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D., Williams, L. T. (1998). A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T�lymphocytes. Proc. Natl. Acad. Sci. USA 95: 258-263 [Abstract] [Full Text]
Chang, M.-s., McNinch, J., Elias III, C., Manthey, C. L., Grosshans, D., Meng, T., Boone, T., Andrew, D. P. (1997). Molecular Cloning and Functional Characterization of a Novel CC Chemokine, Stimulated T Cell Chemotactic Protein (STCP-1) That Specifically Acts on Activated T Lymphocytes. J. Biol. Chem. 272: 25229-25237 [Abstract] [Full Text]
Nagira, M., Imai, T., Hieshima, K., Kusuda, J., Ridanpaa, M., Takagi, S., Nishimura, M., Kakizaki, M., Nomiyama, H., Yoshie, O. (1997). Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13. J. Biol. Chem. 272: 19518-19524 [Abstract] [Full Text]
Haribabu, B., Steeber, D. A., Ali, H., Richardson, R. M., Snyderman, R., Tedder, T. F. (1997). Chemoattractant Receptor-induced Phosphorylation of L-selectin. J. Biol. Chem. 272: 13961-13965 [Abstract] [Full Text]
Wu, L., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., Choe, H., Sodroski, J., Newman, W., Koup, R. A., Mackay, C. R. (1997). CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro. JEM 185: 1681-1692 [Abstract] [Full Text]
Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., Mackay, C. R. (1997). The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T�lymphocytes. Proc. Natl. Acad. Sci. USA 94: 1925-1930 [Abstract] [Full Text]
Hunt, S. W. III, Harris, E. S., Kellermann, S.-A., Shimizu, Y. (1996). T-Lymphocyte Interactions With Endothelium and Extracellular Matrix. fake Crit Rev Oral Biol Med 7: 59-86 [Abstract] [Full Text]
Hoover, D. M., Mizoue, L. S., Handel, T. M., Lubkowski, J. (2000). The Crystal Structure of the Chemokine Domain of Fractalkine Shows a Novel Quaternary Arrangement. J. Biol. Chem. 275: 23187-23193 [Abstract] [Full Text]
Feigelson, S. W., Grabovsky, V., Winter, E., Chen, L. L., Pepinsky, R. B., Yednock, T., Yablonski, D., Lobb, R., Alon, R. (2001). The Src Kinase p56lck Up-regulates VLA-4 Integrin Affinity. IMPLICATIONS FOR RAPID SPONTANEOUS AND CHEMOKINE-TRIGGERED T CELL ADHESION TO VCAM-1 AND FIBRONECTIN. J. Biol. Chem. 276: 13891-13901 [Abstract] [Full Text]