The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected] [published erratum appears in J Exp Med 1993 Sep 1;178(3):1135]

doi:10.1084/jem.178.1.245

This Article

	Full Text (PDF, 1175K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Levin, S. D.
	Articles by Perlmutter, R. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Levin, S. D.
	Articles by Perlmutter, R. M.


Social Bookmarking

	What's this?

ARTICLES

The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected] [published erratum appears in J Exp Med 1993 Sep 1;178(3):1135]

SD Levin, KM Abraham, SJ Anderson, KA Forbush and RM Perlmutter
Howard Hughes Medical Institute, University of Washington, Seattle 98195.

The lck gene encodes a lymphocyte-specific protein tyrosine kinase of the nonreceptor type that is implicated in signal transduction pathways emanating from the CD4 and CD8 coreceptors. Previous studies also support a role for p56lck in regulating T cell receptor beta gene rearrangements and, more generally, thymocyte development. Here we report that a mutant form of p56lck, which is incapable of interacting with CD4 or CD8, behaves indistinguishably from association-competent p56lck with respect to its ability to affect thymocyte maturation. The effects of p56lck remained specific in that the closely related src- family kinase p59hck was incapable of substituting for p56lck in arresting beta locus gene rearrangements. These data support the view that src-family kinases perform highly specialized and often nonoverlapping functions in hematopoietic cells, and that p56lck acts independently of its association with CD4 and CD8 to regulate thymocyte development.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Trobridge, P. A., Forbush, K. A., Levin, S. D. (2001). Positive and Negative Selection of Thymocytes Depends on Lck Interaction with the CD4 and CD8 Coreceptors. J. Immunol. 166: 809-818 [Abstract] [Full Text]
Lin, K., Longo, N. S., Wang, X., Hewitt, J. A., Abraham, K. M. (2000). Lck Domains Differentially Contribute to Pre-T Cell Receptor (TCR)- and TCR-{alpha}/{beta}-regulated Developmental Transitions. JEM 191: 703-716 [Abstract] [Full Text]
Takemoto, Y., Furuta, M., Sato, M., Kubo, M., Hashimoto, Y. (1999). Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. Int Immunol 11: 1957-1964 [Abstract] [Full Text]
Seavitt, J. R., White, L. S., Murphy, K. M., Loh, D. Y., Perlmutter, R. M., Thomas, M. L. (1999). Expression of the p56lck Y505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development. Mol. Cell. Biol. 19: 4200-4208 [Abstract] [Full Text]
Mitnacht, R., Bischof, A., Torres-Nagel, N., Hunig, T. (1998). Opposite CD4/CD8 Lineage Decisions of CD4+8+ Mouse and Rat Thymocytes to Equivalent Triggering Signals: Correlation with Thymic Expression of a Truncated CD8{alpha} Chain in Mice But Not Rats. J. Immunol. 160: 700-707 [Abstract] [Full Text]