Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells

doi:10.1084/jem.177.6.1809

This Article

	Full Text (PDF, 573K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Taub, D. D.
	Articles by Oppenheim, J. J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Taub, D. D.
	Articles by Oppenheim, J. J.


Social Bookmarking

	What's this?

ARTICLES

Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells

DD Taub, AR Lloyd, K Conlon, JM Wang, JR Ortaldo, A Harada, K Matsushima, DJ Kelvin and JJ Oppenheim
Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702.

The human cytokine interferon-inducible protein 10 (IP-10) is a small glycoprotein secreted by activated T cells, monocytes, endothelial cells, and keratinocytes, and is structurally related to a family of chemotactic cytokines called chemokines. Although this protein is present in sites of delayed-type hypersensitivity reactions and lepromatous leprosy lesions, the biological activity of IP-10 remains unknown. We report here that recombinant human IP-10 stimulated significant in vitro chemotaxis of human peripheral blood monocytes but not neutrophils. Recombinant human IP-10 also stimulated chemotaxis of stimulated, but not unstimulated, human peripheral blood T lymphocytes. Phenotypic analysis of the stimulated T cell population responsive to IP-10 demonstrated that stimulated CD4+ and CD29+ T cells migrated in response to IP-10. This resembles the biological activity of the previously described T cell chemoattractant RANTES. Using an endothelial cell adhesion assay, we demonstrated that stimulated T cells pretreated with optimal doses of IP-10 exhibited a greatly enhanced ability to bind to an interleukin 1-treated endothelial cell monolayer. These results demonstrate that the IP-10 gene encodes for an inflammatory mediator that specifically stimulates the directional migration of T cells and monocytes as well as potentiates T cell adhesion to endothelium.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Riemer, C., Schultz, J., Burwinkel, M., Schwarz, A., Mok, S. W. F., Gultner, S., Bamme, T., Norley, S., van Landeghem, F., Lu, B., Gerard, C., Baier, M. (2008). Accelerated Prion Replication in, but Prolonged Survival Times of, Prion-Infected CXCR3-/- Mice. J. Virol. 82: 12464-12471 [Abstract] [Full Text]
Dejnirattisai, W., Duangchinda, T., Lin, C.-L. S., Vasanawathana, S., Jones, M., Jacobs, M., Malasit, P., Xu, X.-n., Screaton, G., Mongkolsapaya, J. (2008). A Complex Interplay among Virus, Dendritic Cells, T Cells, and Cytokines in Dengue Virus Infections. J. Immunol. 181: 5865-5874 [Abstract] [Full Text]
Dominguez, F., Martinez, S., Quinonero, A., Loro, F., Horcajadas, J.A., Pellicer, A., Simon, C. (2008). CXCL10 and IL-6 induce chemotaxis in human trophoblast cell lines. Mol Hum Reprod 14: 423-430 [Abstract] [Full Text]
West, J., Damania, B. (2008). Upregulation of the TLR3 Pathway by Kaposi's Sarcoma-Associated Herpesvirus during Primary Infection. J. Virol. 82: 5440-5449 [Abstract] [Full Text]
Feld, M., Shpacovitch, V. M., Ehrhardt, C., Kerkhoff, C., Hollenberg, M. D., Vergnolle, N., Ludwig, S., Steinhoff, M. (2008). Agonists of Proteinase-Activated Receptor-2 Enhance IFN-{gamma}-Inducible Effects on Human Monocytes: Role in Influenza A Infection. J. Immunol. 180: 6903-6910 [Abstract] [Full Text]
Walsh, K. B., Lodoen, M. B., Edwards, R. A., Lanier, L. L., Lane, T. E. (2008). Evidence for Differential Roles for NKG2D Receptor Signaling in Innate Host Defense against Coronavirus-Induced Neurological and Liver Disease. J. Virol. 82: 3021-3030 [Abstract] [Full Text]
Eskan, M. A., Rose, B. G., Benakanakere, M. R., Lee, M.-J., Kinane, D. F. (2008). Sphingosine 1-Phosphate 1 and TLR4 Mediate IFN-{beta} Expression in Human Gingival Epithelial Cells. J. Immunol. 180: 1818-1825 [Abstract] [Full Text]
Figarola, J. L., Shanmugam, N., Natarajan, R., Rahbar, S. (2007). Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes. Diabetes 56: 647-655 [Abstract] [Full Text]
Dame, T. M., Orenzoff, B. L., Palmer, L. E., Furie, M. B. (2007). IFN-{gamma} Alters the Response of Borrelia burgdorferi-Activated Endothelium to Favor Chronic Inflammation. J. Immunol. 178: 1172-1179 [Abstract] [Full Text]
Korpi-Steiner, N. L., Bates, M. E., Lee, W.-M., Hall, D. J., Bertics, P. J. (2006). Human rhinovirus induces robust IP-10 release by monocytic cells, which is independent of viral replication but linked to type I interferon receptor ligation and STAT1 activation. J. Leukoc. Biol. 80: 1364-1374 [Abstract] [Full Text]
Chen, J.-P., Lu, H.-L., Lai, S.-L., Campanella, G. S., Sung, J.-M., Lu, M.-Y., Wu-Hsieh, B. A., Lin, Y.-L., Lane, T. E., Luster, A. D., Liao, F. (2006). Dengue Virus Induces Expression of CXC Chemokine Ligand 10/IFN-{gamma}-Inducible Protein 10, Which Competitively Inhibits Viral Binding to Cell Surface Heparan Sulfate.. J. Immunol. 177: 3185-3192 [Abstract] [Full Text]
Zirger, J. M., Barcia, C., Liu, C., Puntel, M., Mitchell, N., Campbell, I., Castro, M., Lowenstein, P. R. (2006). Rapid Upregulation of Interferon-Regulated and Chemokine mRNAs upon Injection of 108 International Units, but Not Lower Doses, of Adenoviral Vectors into the Brain.. J. Virol. 80: 5655-5659 [Abstract] [Full Text]
Takeuchi, M., Oh-i, K., Suzuki, J., Hattori, T., Takeuchi, A., Okunuki, Y., Usui, Y., Usui, M. (2006). Elevated Serum Levels of CXCL9/Monokine Induced by Interferon-{gamma} and CXCL10/Interferon-{gamma}-Inducible Protein-10 in Ocular Sarcoidosis.. IOVS 47: 1063-1068 [Abstract] [Full Text]
Chen, C.-N., Chang, S.-F., Lee, P.-L., Chang, K., Chen, L.-J., Usami, S., Chien, S., Chiu, J.-J. (2006). Neutrophils, lymphocytes, and monocytes exhibit diverse behaviors in transendothelial and subendothelial migrations under coculture with smooth muscle cells in disturbed flow. Blood 107: 1933-1942 [Abstract] [Full Text]
Pan, J., Burdick, M. D., Belperio, J. A., Xue, Y. Y., Gerard, C., Sharma, S., Dubinett, S. M., Strieter, R. M. (2006). CXCR3/CXCR3 Ligand Biological Axis Impairs RENCA Tumor Growth by a Mechanism of Immunoangiostasis. J. Immunol. 176: 1456-1464 [Abstract] [Full Text]
Feldman, E. D., Weinreich, D. M., Carroll, N. M., Burness, M. L., Feldman, A. L., Turner, E., Xu, H., Alexander, H. R. Jr. (2006). Interferon {gamma}-Inducible Protein 10 Selectively Inhibits Proliferation and Induces Apoptosis in Endothelial Cells. Ann. Surg. Oncol. 13: 125-133 [Abstract] [Full Text]
Zhang, H. M., Yuan, J., Cheung, P., Chau, D., Wong, B. W., McManus, B. M., Yang, D. (2005). Gamma Interferon-Inducible Protein 10 Induces HeLa Cell Apoptosis through a p53-Dependent Pathway Initiated by Suppression of Human Papillomavirus Type 18 E6 and E7 Expression. Mol. Cell. Biol. 25: 6247-6258 [Abstract] [Full Text]
Li, G., Tian, L., Hou, J.-m., Ding, Z.-y., He, Q.-m., Feng, P., Wen, Y.-j., Xiao, F., Yao, B., Zhang, R., Peng, F., Jiang, Y., Luo, F., Zhao, X., Zhang, L., Zhou, Q., Wei, Y.-q. (2005). Improved Therapeutic Effectiveness by Combining Recombinant CXC Chemokine Ligand 10 with Cisplatin in Solid Tumors. Clin. Cancer Res. 11: 4217-4224 [Abstract] [Full Text]
McInnis, K. A., Britain, A., Lausch, R. N., Oakes, J. E. (2005). Synthesis of {alpha}-Chemokines IP-10, I-TAC, and MIG Are Differentially Regulated in Human Corneal Keratocytes. IOVS 46: 1668-1674 [Abstract] [Full Text]
Sui, Y., Li, S., Pinson, D., Adany, I., Li, Z., Villinger, F., Narayan, O., Buch, S. (2005). Simian Human Immunodeficiency Virus-Associated Pneumonia Correlates with Increased Expression of MCP-1, CXCL10, and Viral RNA in the Lungs of Rhesus Macaques. Am. J. Pathol. 166: 355-365 [Abstract] [Full Text]
Hildebrandt, G. C., Corrion, L. A., Olkiewicz, K. M., Lu, B., Lowler, K., Duffner, U. A., Moore, B. B., Kuziel, W. A., Liu, C., Cooke, K. R. (2004). Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome. J. Immunol. 173: 2050-2059 [Abstract] [Full Text]
Whiting, D., Hsieh, G., Yun, J. J., Banerji, A., Yao, W., Fishbein, M. C., Belperio, J., Strieter, R. M., Bonavida, B., Ardehali, A. (2004). Chemokine Monokine Induced by IFN-{gamma}/CXC Chemokine Ligand 9 Stimulates T Lymphocyte Proliferation and Effector Cytokine Production. J. Immunol. 172: 7417-7424 [Abstract] [Full Text]
Burnett, M. S., Durrani, S., Stabile, E., Saji, M., Lee, C. W., Kinnaird, T. D., Hoffman, E. P., Epstein, S. E. (2004). Murine Cytomegalovirus Infection Increases Aortic Expression of Proatherosclerotic Genes. Circulation 109: 893-897 [Abstract] [Full Text]
Schroder, K., Hertzog, P. J., Ravasi, T., Hume, D. A. (2004). Interferon-{gamma}: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75: 163-189 [Abstract] [Full Text]
Stanford, M. M., Issekutz, T. B. (2003). The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo. J. Leukoc. Biol. 74: 791-799 [Abstract] [Full Text]
Belperio, J. A., Keane, M. P., Burdick, M. D., Lynch, J. P. III, Zisman, D. A., Xue, Y. Y., Li, K., Ardehali, A., Ross, D. J., Strieter, R. M. (2003). Role of CXCL9/CXCR3 Chemokine Biology during Pathogenesis of Acute Lung Allograft Rejection. J. Immunol. 171: 4844-4852 [Abstract] [Full Text]
Carr, D. J. J., Chodosh, J., Ash, J., Lane, T. E. (2003). Effect of Anti-CXCL10 Monoclonal Antibody on Herpes Simplex Virus Type 1 Keratitis and Retinal Infection. J. Virol. 77: 10037-10046 [Abstract] [Full Text]
Harvey, C. E., Post, J. J., Palladinetti, P., Freeman, A. J., Ffrench, R. A., Kumar, R. K., Marinos, G., Lloyd, A. R. (2003). Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation. J. Leukoc. Biol. 74: 360-369 [Abstract] [Full Text]
Veckman, V., Miettinen, M., Matikainen, S., Lande, R., Giacomini, E., Coccia, E. M., Julkunen, I. (2003). Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis. J. Leukoc. Biol. 74: 395-402 [Abstract] [Full Text]
Singh, U. P., Singh, S., Taub, D. D., Lillard, J. W. Jr. (2003). Inhibition of IFN-{gamma}-Inducible Protein-10 Abrogates Colitis in IL-10-/- Mice. J. Immunol. 171: 1401-1406 [Abstract] [Full Text]
Campanella, G. S. V., Lee, E. M. J., Sun, J., Luster, A. D. (2003). CXCR3 and Heparin Binding Sites of the Chemokine IP-10 (CXCL10). J. Biol. Chem. 278: 17066-17074 [Abstract] [Full Text]
Shanmugam, N., Reddy, M. A., Guha, M., Natarajan, R. (2003). High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells. Diabetes 52: 1256-1264 [Abstract] [Full Text]
Nagaoka, K., Sakai, A., Nojima, H., Suda, Y., Yokomizo, Y., Imakawa, K., Sakai, S., Christenson, R. K. (2003). A Chemokine, Interferon (IFN)-{gamma}-Inducible Protein 10 kDa, Is Stimulated by IFN-{tau} and Recruits Immune Cells in the Ovine Endometrium. Biol. Reprod. 68: 1413-1421 [Abstract] [Full Text]
Hill, N. J., Van Gunst, K., Sarvetnick, N. (2003). Th1 and Th2 Pancreatic Inflammation Differentially Affects Homing of Islet-Reactive CD4 Cells in Nonobese Diabetic Mice. J. Immunol. 170: 1649-1658 [Abstract] [Full Text]
Gao, P., Zhou, X.-Y., Yashiro-Ohtani, Y., Yang, Y.-F., Sugimoto, N., Ono, S., Nakanishi, T., Obika, S., Imanishi, T., Egawa, T., Nagasawa, T., Fujiwara, H., Hamaoka, T. (2003). The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3. J. Leukoc. Biol. 73: 273-280 [Abstract] [Full Text]
Lettinga, K D, Weijer, S, Speelman, P, Prins, J M, van der Poll, T, Verbon, A (2003). Reduced interferon-{gamma} release in patients recovered from Legionnaires' disease. Thorax 58: 63-67 [Abstract] [Full Text]
Kury, P., Greiner-Petter, R., Cornely, C., Jurgens, T., Muller, H. W. (2002). Mammalian Achaete Scute Homolog 2 Is Expressed in the Adult Sciatic Nerve and Regulates the Expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann Cells. J. Neurosci. 22: 7586-7595 [Abstract] [Full Text]
Inston, N. G., Cockwell, P. (2002). The evolving role of chemokines and their receptors in acute allograft rejection. Nephrol Dial Transplant 17: 1374-1379 [Full Text]
Boztug, K., Carson, M. J., Pham-Mitchell, N., Asensio, V. C., DeMartino, J., Campbell, I. L. (2002). Leukocyte Infiltration, But Not Neurodegeneration, in the CNS of Transgenic Mice with Astrocyte Production of the CXC Chemokine Ligand 10. J. Immunol. 169: 1505-1515 [Abstract] [Full Text]
Belperio, J. A., Keane, M. P., Burdick, M. D., Lynch, J. P. III, Xue, Y. Y., Li, K., Ross, D. J., Strieter, R. M. (2002). Critical Role for CXCR3 Chemokine Biology in the Pathogenesis of Bronchiolitis Obliterans Syndrome. J. Immunol. 169: 1037-1049 [Abstract] [Full Text]
Uekusa, Y., Yu, W.-G., Mukai, T., Gao, P., Yamaguchi, N., Murai, M., Matsushima, K., Obika, S., Imanishi, T., Higashibata, Y., Nomura, S., Kitamura, Y., Fujiwara, H., Hamaoka, T. (2002). A Pivotal Role for CC Chemokine Receptor 5 in T-Cell Migration to Tumor Sites Induced by Interleukin 12 Treatment in Tumor-bearing Mice. Cancer Res. 62: 3751-3758 [Abstract] [Full Text]
Saetta, M., Mariani, M., Panina-Bordignon, P., Turato, G., Buonsanti, C., Baraldo, S., Bellettato, C. M., Papi, A., Corbetta, L., Zuin, R., Sinigaglia, F., Fabbri, L. M. (2002). Increased Expression of the Chemokine Receptor CXCR3 and Its Ligand CXCL10 in Peripheral Airways of Smokers with Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 165: 1404-1409 [Abstract] [Full Text]
Cockwell, P., Calderwood, J. W., Brooks, C. J., Chakravorty, S. J., Savage, C. O. S. (2002). Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines. Nephrol Dial Transplant 17: 734-744 [Abstract] [Full Text]
Brassard, D. L., Grace, M. J., Bordens, R. W. (2002). Interferon-{alpha} as an immunotherapeutic protein. J. Leukoc. Biol. 71: 565-581 [Abstract] [Full Text]
D'Aversa, T. G., Weidenheim, K. M., Berman, J. W. (2002). CD40-CD40L Interactions Induce Chemokine Expression by Human Microglia : Implications for Human Immunodeficiency Virus Encephalitis and Multiple Sclerosis. Am. J. Pathol. 160: 559-567 [Abstract] [Full Text]
Power, U. F., Huss, T., Michaud, V., Plotnicky-Gilquin, H., Bonnefoy, J.-Y., Nguyen, T. N. (2001). Differential Histopathology and Chemokine Gene Expression in Lung Tissues following Respiratory Syncytial Virus (RSV) Challenge of Formalin-Inactivated RSV- or BBG2Na-Immunized Mice. J. Virol. 75: 12421-12430 [Abstract] [Full Text]
Proost, P., Schutyser, E., Menten, P., Struyf, S., Wuyts, A., Opdenakker, G., Detheux, M., Parmentier, M., Durinx, C., Lambeir, A.-M., Neyts, J., Liekens, S., Maudgal, P. C., Billiau, A., Van Damme, J. (2001). Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties. Blood 98: 3554-3561 [Abstract] [Full Text]
Soejima, K., Rollins, B. J. (2001). A Functional IFN-{gamma}-Inducible Protein-10/CXCL10-Specific Receptor Expressed by Epithelial and Endothelial Cells That Is Neither CXCR3 Nor Glycosaminoglycan. J. Immunol. 167: 6576-6582 [Abstract] [Full Text]
McMahon, E. J., Cook, D. N., Suzuki, K., Matsushima, G. K. (2001). Absence of Macrophage-Inflammatory Protein-1{alpha} Delays Central Nervous System Demyelination in the Presence of an Intact Blood-Brain Barrier. J. Immunol. 167: 2964-2971 [Abstract] [Full Text]
Asensio, V. C., Maier, J., Milner, R., Boztug, K., Kincaid, C., Moulard, M., Phillipson, C., Lindsley, K., Krucker, T., Fox, H. S., Campbell, I. L. (2001). Interferon-Independent, Human Immunodeficiency Virus Type 1 gp120-Mediated Induction of CXCL10/IP-10 Gene Expression by Astrocytes In Vivo and In Vitro. J. Virol. 75: 7067-7077 [Abstract] [Full Text]
Qiu, B., Frait, K. A., Reich, F., Komuniecki, E., Chensue, S. W. (2001). Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation. Am. J. Pathol. 158: 1503-1515 [Abstract] [Full Text]
Ding, Z., Xiong, K., Issekutz, T. B. (2001). Chemokines stimulate human T lymphocyte transendothelial migration to utilize VLA-4 in addition to LFA-1. J. Leukoc. Biol. 69: 458-466 [Abstract] [Full Text]
Wiley, R. E., Palmer, K., Gajewska, B. U., Stampfli, M. R., Alvarez, D., Coyle, A. J., Gutierrez-Ramos, J.-C., Jordana, M. (2001). Expression of the Th1 Chemokine IFN-{{gamma}}-Inducible Protein 10 in the Airway Alters Mucosal Allergic Sensitization in Mice. J. Immunol. 166: 2750-2759 [Abstract] [Full Text]
Patzwahl, R., Meier, V., Ramadori, G., Mihm, S. (2001). Enhanced Expression of Interferon-Regulated Genes in the Liver of Patients with Chronic Hepatitis C Virus Infection: Detection by Suppression-Subtractive Hybridization. J. Virol. 75: 1332-1338 [Abstract] [Full Text]
TICCHIONI, M., RAIMONDI, V., LAMY, L., WIJDENES, J., LINDBERG, F. P., BROWN, E. J., BERNARD, A. (2001). Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium under flow. FASEB J. 15: 341-350 [Abstract] [Full Text]
Cao, Z., Baguley, B. C, Ching, L.-M. (2001). Interferon-inducible Protein 10 Induction and Inhibition of Angiogenesis in Vivo by the Antitumor Agent 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA). Cancer Res. 61: 1517-1521 [Abstract] [Full Text]
Di Carlo, E., Forni, G., Lollini, P., Colombo, M. P., Modesti, A., Musiani, P. (2001). The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood 97: 339-345 [Full Text]
Perera, P.-Y., Mayadas, T. N., Takeuchi, O., Akira, S., Zaks-Zilberman, M., Goyert, S. M., Vogel, S. N. (2001). CD11b/CD18 Acts in Concert with CD14 and Toll-Like Receptor (TLR) 4 to Elicit Full Lipopolysaccharide and Taxol-Inducible Gene Expression. J. Immunol. 166: 574-581 [Abstract] [Full Text]
Wetzel, M. A., Steele, A. D., Eisenstein, T. K., Adler, M. W., Henderson, E. E., Rogers, T. J. (2000). {micro}-Opioid Induction of Monocyte Chemoattractant Protein-1, RANTES, and IFN-{gamma}-Inducible Protein-10 Expression in Human Peripheral Blood Mononuclear Cells. J. Immunol. 165: 6519-6524 [Abstract] [Full Text]
Kutsch, O., Oh, J.-W., Nath, A., Benveniste, E. N. (2000). Induction of the Chemokines Interleukin-8 and IP-10 by Human Immunodeficiency Virus Type 1 Tat in Astrocytes. J. Virol. 74: 9214-9221 [Abstract] [Full Text]
Dixon, A. E., Mandac, J. B., Madtes, D. K., Martin, P. J., Clark, J. G. (2000). Chemokine expression in Th1 cell-induced lung injury: prominence of IFN-gamma -inducible chemokines. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L592-L599 [Abstract] [Full Text]
Lauw, F. N., Simpson, A. J. H., Prins, J. M., van Deventer, S. J. H., Chaowagul, W., White, N. J., van der Poll, T. (2000). The CXC Chemokines Gamma Interferon (IFN-gamma )-Inducible Protein 10 and Monokine Induced by IFN-gamma Are Released during Severe Melioidosis. Infect. Immun. 68: 3888-3893 [Abstract] [Full Text]
Bromley, S. K., Peterson, D. A., Gunn, M. D., Dustin, M. L. (2000). Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation. J. Immunol. 165: 15-19 [Abstract] [Full Text]
Wang, X., Li, X., Schmidt, D. B., Foley, J. J., Barone, F. C., Ames, R. S., Sarau, H. M. (2000). Identification and Molecular Characterization of Rat CXCR3: Receptor Expression and Interferon-Inducible Protein-10 Binding Are Increased in Focal Stroke. Mol. Pharmacol. 57: 1190-1198 [Abstract] [Full Text]
Dawson, T. C., Beck, M. A., Kuziel, W. A., Henderson, F., Maeda, N. (2000). Contrasting Effects of CCR5 and CCR2 Deficiency in the Pulmonary Inflammatory Response to Influenza A Virus. Am. J. Pathol. 156: 1951-1959 [Abstract] [Full Text]
Murdoch, C., Finn, A. (2000). Chemokine receptors and their role in inflammation and infectious diseases. Blood 95: 3032-3043 [Abstract] [Full Text]
Borgland, S. L., Bowen, G. P., Wong, N. C. W., Libermann, T. A., Muruve, D. A. (2000). Adenovirus Vector-Induced Expression of the C-X-C Chemokine IP-10 Is Mediated through Capsid-Dependent Activation of NF-kappa B. J. Virol. 74: 3941-3947 [Abstract] [Full Text]
Rottenberg, M. E., Gigliotti Rothfuchs, A., Gigliotti, D., Ceausu, M., Une, C., Levitsky, V., Wigzell, H. (2000). Regulation and Role of IFN-{gamma} in the Innate Resistance to Infection with Chlamydia pneumoniae. J. Immunol. 164: 4812-4818 [Abstract] [Full Text]
Matejuk, A., Vandenbark, A. A., Burrows, G. G., Bebo, B. F. Jr., Offner, H. (2000). Reduced Chemokine and Chemokine Receptor Expression in Spinal Cords of TCR BV8S2 Transgenic Mice Protected Against Experimental Autoimmune Encephalomyelitis with BV8S2 Protein. J. Immunol. 164: 3924-3931 [Abstract] [Full Text]
Narvaiza, I., Mazzolini, G., Barajas, M., Duarte, M., Zaratiegui, M., Qian, C., Melero, I., Prieto, J. (2000). Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-{gamma}-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy. J. Immunol. 164: 3112-3122 [Abstract] [Full Text]
McGuinness, P H, Painter, D, Davies, S, McCaughan, G W (2000). Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. Gut 46: 260-269 [Abstract] [Full Text]
Johnson-Leger, C, Aurrand-Lions, M, Imhof, B. (2000). The parting of the endothelium: miracle, or simply a junctional affair?. J. Cell Sci. 113: 921-933 [Abstract]
Juedes, A. E., Hjelmstrom, P., Bergman, C. M., Neild, A. L., Ruddle, N. H. (2000). Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis. J. Immunol. 164: 419-426 [Abstract] [Full Text]
Yamagami, S., Miyazaki, D., Ono, S. J., Dana, M. R. (1999). Differential Chemokine Gene Expression in Corneal Transplant Rejection. IOVS 40: 2892-2897 [Abstract] [Full Text]
Bukowski, R. M., Rayman, P., Molto, L., Tannenbaum, C. S., Olencki, T., Peereboom, D., Tubbs, R., McLain, D., Budd, G. T., Griffin, T., Novick, A., Hamilton, T. A., Finke, J. (1999). Interferon-{{gamma}} and CXC Chemokine Induction by Interleukin 12 in Renal Cell Carcinoma. Clin. Cancer Res. 5: 2780-2789 [Abstract] [Full Text]
Kawai, T., Seki, M., Hiromatsu, K., Eastcott, J. W., Watts, G. F. M., Sugai, M., Smith, D. J., Porcelli, S. A., Taubman, M. A. (1999). Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES. J. Immunol. 163: 3269-3278 [Abstract] [Full Text]
Chung, K F, Barnes, P J (1999). Cytokines in asthma. Thorax 54: 825-857 [Full Text]
Juffermans, N. P., Verbon, A., van Deventer, S. J. H., van Deutekom, H., Belisle, J. T., Ellis, M. E., Speelman, P., van der Poll, T. (1999). Elevated Chemokine Concentrations in Sera of Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Patients with Tuberculosis: a Possible Role for Mycobacterial Lipoarabinomannan. Infect. Immun. 67: 4295-4297 [Abstract] [Full Text]
Kopydlowski, K. M., Salkowski, C. A., Cody, M. J., van Rooijen, N., Major, J., Hamilton, T. A., Vogel, S. N. (1999). Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo. J. Immunol. 163: 1537-1544 [Abstract] [Full Text]
Ogawa, M., Umehara, K., Yu, W.-G., Uekusa, Y., Nakajima, C., Tsujimura, T., Kubo, T., Fujiwara, H., Hamaoka, T. (1999). A Critical Role for a Peritumoral Stromal Reaction in the Induction of T-Cell Migration Responsible for Interleukin-12-induced Tumor Regression. Cancer Res. 59: 1531-1538 [Abstract] [Full Text]
Wei, S., Wei, W., Sedivy, J. M. (1999). Expression of Catalytically Active Telomerase Does Not Prevent Premature Senescence Caused by Overexpression of Oncogenic Ha-Ras in Normal Human Fibroblasts. Cancer Res. 59: 1539-1543 [Abstract] [Full Text]
Asensio, V. C., Lassmann, S., Pagenstecher, A., Steffensen, S. C., Henriksen, S. J., Campbell, I. L. (1999). C10 Is a Novel Chemokine Expressed in Experimental Inflammatory Demyelinating Disorders that Promotes Recruitment of Macrophages to the Central Nervous System. Am. J. Pathol. 154: 1181-1191 [Abstract] [Full Text]
Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999). The T Cell-Specific CXC Chemokines IP-10, Mig, and I-TAC Are Expressed by Activated Human Bronchial Epithelial Cells. J. Immunol. 162: 3549-3558 [Abstract] [Full Text]
Mahalingam, S., Farber, J. M., Karupiah, G. (1999). The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo. J. Virol. 73: 1479-1491 [Abstract] [Full Text]
Neumann, B., Zantl, N., Veihelmann, A., Emmanuilidis, K., Pfeffer, K., Heidecke, C.-D., Holzmann, B. (1999). Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Int Immunol 11: 217-227 [Abstract] [Full Text]
Cavallo, F., Carlo, E. D., Butera, M., Verrua, R., Colombo, M. P., Musiani, P., Forni, G. (1999). Immune Events Associated with the Cure of Established Tumors and Spontaneous Metastases by Local and Systemic Interleukin 12. Cancer Res. 59: 414-421 [Abstract] [Full Text]
Liao, F., Rabin, R. L., Smith, C. S., Sharma, G., Nutman, T. B., Farber, J. M. (1999). CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3{alpha}. J. Immunol. 162: 186-194 [Abstract] [Full Text]
Peacock, J. W., Jirik, F. R. (1999). TCR Activation Inhibits Chemotaxis Toward Stromal Cell-Derived Factor-1: Evidence for Reciprocal Regulation Between CXCR4 and the TCR. J. Immunol. 162: 215-223 [Abstract] [Full Text]
Horton, M. R., McKee, C. M., Bao, C., Liao, F., Farber, J. M., Hodge-DuFour, J., Pure, E., Oliver, B. L., Wright, T. M., Noble, P. W. (1998). Hyaluronan Fragments Synergize with Interferon-gamma to Induce the C-X-C Chemokines Mig and Interferon-inducible Protein-10 in Mouse Macrophages. J. Biol. Chem. 273: 35088-35094 [Abstract] [Full Text]
Cuff, C. A., Schwartz, J., Bergman, C. M., Russell, K. S., Bender, J. R., Ruddle, N. H. (1998). Lymphotoxin {alpha}3 Induces Chemokines and Adhesion Molecules: Insight into the Role of LT{alpha} in Inflammation and Lymphoid Organ Development. J. Immunol. 161: 6853-6860 [Abstract] [Full Text]
van den Berg, R. H., Faber-Krol, M. C., Sim, R. B., Daha, M. R. (1998). The First Subcomponent of Complement, C1q, Triggers the Production of IL-8, IL-6, and Monocyte Chemoattractant Peptide-1 by Human Umbilical Vein Endothelial Cells. J. Immunol. 161: 6924-6930 [Abstract] [Full Text]
Barnes, P. J., Chung, K. F., Page, C. P. (1998). Inflammatory Mediators of Asthma: An Update. Pharmacol. Rev. 50: 515-596 [Abstract] [Full Text]
Engelhardt, E., Toksoy, A., Goebeler, M., Debus, S., Brocker, E.-B., Gillitzer, R. (1998). Chemokines IL-8, GRO{alpha}, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing. Am. J. Pathol. 153: 1849-1860 [Abstract] [Full Text]
Agostini, C., Cassatella, M., Zambello, R., Trentin, L., Gasperini, S., Perin, A., Piazza, F., Siviero, M., Facco, M., Dziejman, M., Chilosi, M., Qin, S., Luster, A. D., Semenzato, G. (1998). Involvement of the IP-10 Chemokine in Sarcoid Granulomatous Reactions. J. Immunol. 161: 6413-6420 [Abstract] [Full Text]
Majumder, S., Zhou, L. Z.-H., Chaturvedi, P., Babcock, G., Aras, S., Ransohoff, R. M. (1998). p48/STAT-1{alpha}-Containing Complexes Play a Predominant Role in Induction of IFN-{gamma}-Inducible Protein, 10 kDa (IP-10) by IFN-{gamma} Alone or in Synergy with TNF-{alpha}. J. Immunol. 161: 4736-4744 [Abstract] [Full Text]
Nakamura, H., Haley, K. J., Nakamura, T., Luster, A. D., Lilly, C. M. (1998). Differential regulation of eotaxin expression by TNF-alpha and PMA in human monocytic U-937 cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 275: L601-L610 [Abstract] [Full Text]
Mattapallil, J. J., Smit-McBride, Z., McChesney, M., Dandekar, S. (1998). Intestinal Intraepithelial Lymphocytes Are Primed for Gamma Interferon and MIP-1beta Expression and Display Antiviral Cytotoxic Activity despite Severe CD4+ T-Cell Depletion in Primary Simian Immunodeficiency Virus Infection. J. Virol. 72: 6421-6429 [Abstract] [Full Text]
Bot, A., Bot, S., Bona, C. A. (1998). Protective Role of Gamma Interferon during the Recall Response to Influenza Virus. J. Virol. 72: 6637-6645 [Abstract] [Full Text]
Hu, J., You, S., Li, W., Wang, D., Nagpal, M. L., Mi, Y., Liang, P., Lin, T. (1998). Expression and Regulation of Interferon-{gamma}-Inducible Protein 10 Gene in Rat Leydig Cells. Endocrinology 139: 3637-3645 [Abstract] [Full Text]
Tannenbaum, C. S., Tubbs, R., Armstrong, D., Finke, J. H., Bukowski, R. M., Hamilton, T. A. (1998). The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor. J. Immunol. 161: 927-932 [Abstract] [Full Text]