Receptor editing: an approach by autoreactive B cells to escape tolerance

doi:10.1084/jem.177.4.999

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Receptor editing: an approach by autoreactive B cells to escape tolerance

D Gay, T Saunders, S Camper and M Weigert
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.

To determine the fate of anti-DNA antibody-bearing B cells in normal mice, we generated transgenic mice bearing the heavy (H) and light (L) chain genes of a well-characterized anti-double-stranded DNA antibody. This antibody was originally isolated from a diseased MRL/lpr mouse and has characteristics common to spontaneously arising anti-DNA antibodies. Results show that the H/L transgene (tg) immunoglobulin receptor is not expressed by animals bearing both tgs, although single tg animals (H or L) express their transgenes. Young H/L tg animals express few B cells, whereas adult H/L tg animals maintain almost normal B cell numbers. Analysis of the immunoglobulin receptors used by adult B cells shows that all contain the tg H chain in association with endogenous L chains. These B cells transcribe the L tg as well as the rearranged endogenous L chain gene, and loss of endogenous L chain gene transcription results in resurrection of the 3H9 H/L tg product. Examination of the endogenous L chains used by these cells shows that they represent a highly restricted subset of V genes. Taken together, these data suggest that autoreactive transgenic B cells can rearrange endogenous L chain genes to alter surface receptors. Those L chains that compete successfully with the L tg for H chain binding, and that create a nonautoreactive receptor, allow the B cell to escape deletion. We suggest that this receptor editing is a mechanism used by immature autoreactive B cells to escape tolerance.
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Culton, D. A., O'Conner, B. P., Conway, K. L., Diz, R., Rutan, J., Vilen, B. J., Clarke, S. H. (2006). Early Preplasma Cells Define a Tolerance Checkpoint for Autoreactive B Cells. J. Immunol. 176: 790-802 [Abstract] [Full Text]
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Roy, V., Chang, N.-H., Cai, Y., Bonventi, G., Wither, J. (2005). Aberrant IgM Signaling Promotes Survival of Transitional T1 B Cells and Prevents Tolerance Induction in Lupus-Prone New Zealand Black Mice. J. Immunol. 175: 7363-7371 [Abstract] [Full Text]
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Samuels, J., Ng, Y.-S., Coupillaud, C., Paget, D., Meffre, E. (2005). Impaired early B cell tolerance in patients with rheumatoid arthritis. JEM 201: 1659-1667 [Abstract] [Full Text]
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Novobrantseva, T., Xu, S., Tan, J. E.-L., Maruyama, M., Schwers, S., Pelanda, R., Lam, K.-P. (2005). Stochastic pairing of Ig heavy and light chains frequently generates B cell antigen receptors that are subject to editing in vivo. Int Immunol 17: 343-350 [Abstract] [Full Text]
Ait-Azzouzene, D., Verkoczy, L., Peters, J., Gavin, A., Skog, P., Vela, J. L., Nemazee, D. (2005). An immunoglobulin C{kappa}-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. JEM 201: 817-828 [Abstract] [Full Text]
Yurasov, S., Wardemann, H., Hammersen, J., Tsuiji, M., Meffre, E., Pascual, V., Nussenzweig, M. C. (2005). Defective B cell tolerance checkpoints in systemic lupus erythematosus. JEM 201: 703-711 [Abstract] [Full Text]
Grimaldi, C. M., Hicks, R., Diamond, B. (2005). B Cell Selection and Susceptibility to Autoimmunity. J. Immunol. 174: 1775-1781 [Abstract] [Full Text]
Hayashi, K., Nojima, T., Goitsuka, R., Kitamura, D. (2004). Impaired Receptor Editing in the Primary B Cell Repertoire of BASH-Deficient Mice. J. Immunol. 173: 5980-5988 [Abstract] [Full Text]
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Edry, E., Melamed, D. (2004). Receptor Editing in Positive and Negative Selection of B Lymphopoiesis. J. Immunol. 173: 4265-4271 [Abstract] [Full Text]
Ota, T., Aoki-Ota, M., Tsunoda, K., Simoda, K., Nishikawa, T., Amagai, M., Koyasu, S. (2004). Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism. Int Immunol 16: 1487-1495 [Abstract] [Full Text]
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Cancro, M. P., Kearney, J. F. (2004). B Cell Positive Selection: Road Map to the Primary Repertoire?. J. Immunol. 173: 15-19 [Abstract] [Full Text]
Brady, G. F., Congdon, K. L., Clark, A. G., Sackey, F. N. A., Rudolph, E. H., Radic, M. Z., Foster, M. H. (2004). {kappa} Editing Rescues Autoreactive B Cells Destined for Deletion in Mice Transgenic for a Dual Specific Anti-Laminin Ig. J. Immunol. 172: 5313-5321 [Abstract] [Full Text]
Quong, M. W., Martensson, A., Langerak, A. W., Rivera, R. R., Nemazee, D., Murre, C. (2004). Receptor Editing and Marginal Zone B Cell Development Are Regulated by the Helix-Loop-Helix Protein, E2A. JEM 199: 1101-1112 [Abstract] [Full Text]
Gaudin, E., Hao, Y., Rosado, M. M., Chaby, R., Girard, R., Freitas, A. A. (2004). Positive Selection of B Cells Expressing Low Densities of Self-reactive BCRs. JEM 199: 843-853 [Abstract] [Full Text]
Goodyear, C. S., Narita, M., Silverman, G. J. (2004). In Vivo VL-Targeted Activation-Induced Apoptotic Supraclonal Deletion by a Microbial B Cell Toxin. J. Immunol. 172: 2870-2877 [Abstract] [Full Text]
Su, W., Boursier, L., Padala, A., Sanderson, J. D., Spencer, J. (2004). Biases in Ig {lambda} Light Chain Rearrangements in Human Intestinal Plasma Cells. J. Immunol. 172: 2360-2366 [Abstract] [Full Text]
Li, Y., Louzoun, Y., Weigert, M. (2004). Editing Anti-DNA B Cells by V{lambda}x. JEM 199: 337-346 [Abstract] [Full Text]
Paul, E., Lutz, J., Erikson, J., Carroll, M. C. (2004). Germinal center checkpoints in B cell tolerance in 3H9 transgenic mice. Int Immunol 16: 377-384 [Abstract] [Full Text]
Chang, N.-H., MacLeod, R., Wither, J. E. (2004). Autoreactive B Cells in Lupus-Prone New Zealand Black Mice Exhibit Aberrant Survival and Proliferation in the Presence of Self-Antigen In Vivo. J. Immunol. 172: 1553-1560 [Abstract] [Full Text]
Aplin, B. D., Keech, C. L., de Kauwe, A. L., Gordon, T. P., Cavill, D., McCluskey, J. (2003). Tolerance through Indifference: Autoreactive B Cells to the Nuclear Antigen La Show No Evidence of Tolerance in a Transgenic Model. J. Immunol. 171: 5890-5900 [Abstract] [Full Text]
Guth, A. M., Zhang, X., Smith, D., Detanico, T., Wysocki, L. J. (2003). Chromatin Specificity of Anti-Double-Stranded DNA Antibodies and a Role for Arg Residues in the Third Complementarity-Determining Region of the Heavy Chain. J. Immunol. 171: 6260-6266 [Abstract] [Full Text]
Ferry, H., Jones, M., Vaux, D. J., Roberts, I. S.D., Cornall, R. J. (2003). The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells. JEM 198: 1415-1425 [Abstract] [Full Text]
Enders, A., Bouillet, P., Puthalakath, H., Xu, Y., Tarlinton, D. M., Strasser, A. (2003). Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation-induced Apoptosis and Deletion of Autoreactive B Cells. JEM 198: 1119-1126 [Abstract] [Full Text]
Lenze, D, Greiner, A, Knorr, C, Anagnostopoulos, I, Stein, H, Hummel, M (2003). Receptor revision of immunoglobulin heavy chain genes in human MALT lymphomas. Mol. Pathol. 56: 249-255 [Abstract] [Full Text]
Wardemann, H., Yurasov, S., Schaefer, A., Young, J. W., Meffre, E., Nussenzweig, M. C. (2003). Predominant Autoantibody Production by Early Human B Cell Precursors. Science 301: 1374-1377 [Abstract] [Full Text]
Jankovic, M., Nussenzweig, M. C. (2003). OcaB regulates transitional B cell selection. Int Immunol 15: 1099-1104 [Abstract] [Full Text]
Feuerstein, N., Shivers, D., Chen, F., Eisenberg, R. A., Finkel, T. H. (2003). Chronic GVH prevents anergy in bone marrow self-reactive B cells: a selective increase in post-endoplasmic reticulum processing and trafficking to the cell surface of autoreactive IgM receptors. Int Immunol 15: 975-985 [Abstract] [Full Text]
Tze, L. E., Hippen, K. L., Behrens, T. W. (2003). Late Immature B Cells (IgMhighIgDneg) Undergo a Light Chain Receptor Editing Response to Soluble Self-Antigen. J. Immunol. 171: 678-682 [Abstract] [Full Text]
Oberdoerffer, P., Novobrantseva, T. I., Rajewsky, K. (2003). Expression of a Targeted {lambda}1 Light Chain Gene Is Developmentally Regulated and Independent of Ig{kappa} Rearrangements. JEM 197: 1165-1172 [Abstract] [Full Text]
Mehr, R., Shahaf, G., Sah, A., Cancro, M. (2003). Asynchronous differentiation models explain bone marrow labeling kinetics and predict reflux between the pre- and immature B cell pools. Int Immunol 15: 301-312 [Abstract] [Full Text]
Qi, C.-F., Martensson, A., Mattioli, M., Dalla-Favera, R., Lobanenkov, V. V., Morse, H. C. III (2003). CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells. Proc. Natl. Acad. Sci. USA 100: 633-638 [Abstract] [Full Text]
Sekiguchi, D. R., Eisenberg, R. A., Weigert, M. (2003). Secondary Heavy Chain Rearrangement: A Mechanism for Generating Anti-double-stranded DNA B Cells. JEM 197: 27-39 [Abstract] [Full Text]
Hayakawa, K., Asano, M., Shinton, S. A., Gui, M., Wen, L.-J., Dashoff, J., Hardy, R. R. (2003). Positive Selection of Anti-Thy-1 Autoreactive B-1 Cells and Natural Serum Autoantibody Production Independent from Bone Marrow B Cell Development. JEM 197: 87-99 [Abstract] [Full Text]
Li, Y., Li, H., Ni, D., Weigert, M. (2002). Anti-DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern. JEM 196: 1543-1552 [Abstract] [Full Text]
Chackerian, B., Lenz, P., Lowy, D. R., Schiller, J. T. (2002). Determinants of Autoantibody Induction by Conjugated Papillomavirus Virus-Like Particles. J. Immunol. 169: 6120-6126 [Abstract] [Full Text]
Meffre, E., Nussenzweig, M. C. (2002). Deletion of immunoglobulin beta in developing B cells leads to cell death. Proc. Natl. Acad. Sci. USA 99: 11334-11339 [Abstract] [Full Text]
Morris, S. C., Dragula, N. L., Finkelman, F. D. (2002). IL-4 Promotes Stat6-Dependent Survival of Autoreactive B Cells In Vivo Without Inducing Autoantibody Production. J. Immunol. 169: 1696-1704 [Abstract] [Full Text]
Santori, F. R., Arsov, I., Lili, M., Vukmanovic, S. (2002). Editing Autoreactive TCR Enables Efficient Positive Selection. J. Immunol. 169: 1729-1734 [Abstract] [Full Text]
Yan, J., Mamula, M. J. (2002). B and T cell tolerance and autoimmunity in autoantibody transgenic mice. Int Immunol 14: 963-971 [Abstract] [Full Text]