The life span of naive alpha/beta T cells in secondary lymphoid organs

doi:10.1084/jem.177.4.891

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The life span of naive alpha/beta T cells in secondary lymphoid organs

H von Boehmer and K Hafen
Basel Institute for Immunology, Switzerland.

We have determined the life span of naive CD4-8+ T cells in T cell receptor transgenic mice. We find that such cells do not divide in secondary lymphoid organs in both normal euthymic mice and T cell- deficient mice. By both continuous labeling and by chasing pulse- labeled cells, we find that the minimum life span of the naive T cells is in the order of 8 wk.
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Metzler, B., Gfeller, P., Wieczorek, G., Li, J., Nuesslein-Hildesheim, B., Katopodis, A., Mueller, M., Brinkmann, V. (2008). Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure. Int Immunol 20: 633-644 [Abstract] [Full Text]
Sen, P., Charini, W. A., Subbramanian, R. A., Manuel, E. R., Kuroda, M. J., Autissier, P. A., Letvin, N. L. (2008). Clonal Focusing of Epitope-Specific CD8+ T Lymphocytes in Rhesus Monkeys following Vaccination and Simian-Human Immunodeficiency Virus Challenge. J. Virol. 82: 805-816 [Abstract] [Full Text]
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Marleau, A. M., Sarvetnick, N. (2005). T cell homeostasis in tolerance and immunity. J. Leukoc. Biol. 78: 575-584 [Abstract] [Full Text]
Tan, J. T., Ernst, B., Kieper, W. C., LeRoy, E., Sprent, J., Surh, C. D. (2002). Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells. JEM 195: 1523-1532 [Abstract] [Full Text]
Tanchot, C., Le Campion, A., Martin, B., Leaument, S., Dautigny, N., Lucas, B. (2002). Conversion of Naive T Cells to a Memory-Like Phenotype in Lymphopenic Hosts Is Not Related to a Homeostatic Mechanism That Fills the Peripheral Naive T Cell Pool. J. Immunol. 168: 5042-5046 [Abstract] [Full Text]
Le Campion, A., Bourgeois, C., Lambolez, F., Martin, B., Leaument, S., Dautigny, N., Tanchot, C., Penit, C., Lucas, B. (2002). Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes. Proc. Natl. Acad. Sci. USA 99: 4538-4543 [Abstract] [Full Text]
Le Campion, A., Lucas, B., Dautigny, N., Leaument, S., Vasseur, F., Penit, C. (2002). Quantitative and Qualitative Adjustment of Thymic T Cell Production by Clonal Expansion of Premigrant Thymocytes. J. Immunol. 168: 1664-1671 [Abstract] [Full Text]
Hassan, J., Reen, D. J. (2001). Human Recent Thymic Emigrants-Identification, Expansion, And Survival Characteristics. J. Immunol. 167: 1970-1976 [Abstract] [Full Text]
Polic, B., Kunkel, D., Scheffold, A., Rajewsky, K. (2001). How alpha beta T cells deal with induced TCRalpha ablation. Proc. Natl. Acad. Sci. USA 10.1073/pnas.141218898v1 [Abstract] [Full Text]
Tough, D. F., Zhang, X., Sprent, J. (2001). An IFN-{{gamma}}-Dependent Pathway Controls Stimulation of Memory Phenotype CD8+ T Cell Turnover In Vivo by IL-12, IL-18, and IFN-{{gamma}}. J. Immunol. 166: 6007-6011 [Abstract] [Full Text]
Sasada, T., Reinherz, E. L. (2001). A Critical Role for CD2 in Both Thymic Selection Events and Mature T Cell Function. J. Immunol. 166: 2394-2403 [Abstract] [Full Text]
Dummer, W., Ernst, B., LeRoy, E., Lee, D.-S., Surh, C. D. (2001). Autologous Regulation of Naive T Cell Homeostasis Within the T Cell Compartment. J. Immunol. 166: 2460-2468 [Abstract] [Full Text]
Clarke, S. R. M., Rudensky, A. Y. (2000). Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes. J. Immunol. 165: 2458-2464 [Abstract] [Full Text]
Boileau, C., Houde, M., Dulude, G., Clegg, C. H., Perreault, C. (2000). Regulation of Extrathymic T Cell Development and Turnover by Oncostatin M. J. Immunol. 164: 5713-5720 [Abstract] [Full Text]
Teague, T. K., Schaefer, B. C., Hildeman, D., Bender, J., Mitchell, T., Kappler, J. W., Marrack, P. (2000). Activation-induced Inhibition of Interleukin 6-mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling. JEM 191: 915-926 [Abstract] [Full Text]
Witherden, D., van Oers, N., Waltzinger, C., Weiss, A., Benoist, C., Mathis, D. (2000). Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules. JEM 191: 355-364 [Abstract] [Full Text]
Kieper, W. C., Jameson, S. C. (1999). Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands. Proc. Natl. Acad. Sci. USA 96: 13306-13311 [Abstract] [Full Text]
Dyall, R., Nikolic-Zugic, J. (1999). The Final Maturation of At Least Some Single-positive CD4hi Thymocytes Does Not Require T Cell Receptor�Major Histocompatibility Complex Contact. JEM 190: 757-764 [Abstract] [Full Text]
Di Rosa, F., Ramaswamy, S., Ridge, J. P., Matzinger, P. (1999). On the Lifespan of Virgin T Lymphocytes. J. Immunol. 163: 1253-1257 [Abstract] [Full Text]
Blish, C. A., Dillon, S. R., Farr, A. G., Fink, P. J. (1999). Anergic CD8+ T Cells Can Persist and Function In Vivo. J. Immunol. 163: 155-164 [Abstract] [Full Text]
Ramanathan, S., Poussier, P. (1999). T Cell Reconstitution of BB/W Rats After the Initiation of Insulitis Precipitates the Onset of Diabetes. J. Immunol. 162: 5134-5142 [Abstract] [Full Text]
Dulude, G., Roy, D.-C., Perreault, C. (1999). The Effect of Graft-versus-Host Disease on T Cell Production and Homeostasis. JEM 189: 1329-1342 [Abstract] [Full Text]
Boursalian, T. E., Bottomly, K. (1999). Survival of Naive CD4 T Cells: Roles of Restricting Versus Selecting MHC Class II and Cytokine Milieu. J. Immunol. 162: 3795-3801 [Abstract] [Full Text]
Kong, F.-k., Chen, C.-l. H., Six, A., Hockett, R. D., Cooper, M. D. (1999). T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool. Proc. Natl. Acad. Sci. USA 96: 1536-1540 [Abstract] [Full Text]
Timm, J. A., Thoman, M. L. (1999). Maturation of CD4+ Lymphocytes in the Aged Microenvironment Results in a Memory-Enriched Population. J. Immunol. 162: 711-717 [Abstract] [Full Text]
Dumont-Girard, F., Roux, E., van Lier, R. A., Hale, G., Helg, C., Chapuis, B., Starobinski, M., Roosnek, E. (1998). Reconstitution of the T-Cell Compartment After Bone Marrow Transplantation: Restoration of the Repertoire by Thymic Emigrants. Blood 92: 4464-4471 [Abstract] [Full Text]
Seitzman, G. D., Sonstein, J., Kim, S., Choy, W., Curtis, J. L. (1998). Lung Lymphocytes Proliferate Minimally in the Murine Pulmonary Immune Response to Intratracheal Sheep Erythrocytes. Am. J. Respir. Cell Mol. Bio. 18: 800-812 [Abstract] [Full Text]
Nesic, D., Vukmanovic, S. (1998). MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants. J. Immunol. 160: 3705-3712 [Abstract] [Full Text]
Tough, D. F., Sprent, J. (1998). Lifespan of gamma /delta T Cells. JEM 187: 357-365 [Abstract] [Full Text]
Brocker, T. (1997). Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II-expressing Dendritic Cells. JEM 186: 1223-1232 [Abstract] [Full Text]
Kirberg, J., Berns, A., Boehmer, H. v. (1997). Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex-Encoded Molecules. JEM 186: 1269-1275 [Abstract] [Full Text]
Tanchot, C., Rocha, B. (1997). Peripheral Selection of �T Cell Repertoires: The Role of Continuous Thymus Output. JEM 186: 1099-1106 [Abstract] [Full Text]
Vella, A., Teague, T. K., Ihle, J., Kappler, J., Marrack, P. (1997). Interleukin 4�(IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4. JEM 186: 325-330 [Abstract] [Full Text]
Tanchot, C., Lemonnier, F. A., Pérarnau, B., Freitas, A. A., Rocha, B. (1997). Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells. Science 276: 2057-2062 [Abstract] [Full Text]
Jecker, P., Beuleke, A., Dressendorfer, I., Pabst, R., Westermann, J. (1997). Long-term Oral Application of 5-Bromo-2-Deoxyuridine Does Not Reliably Label Proliferating Immune Cells in the LEW Rat. J. Histochem. Cytochem. 45: 393-402 [Abstract] [Full Text]
Pihlgren, M., Dubois, P. M., Tomkowiak, M., Sjogren, T., Marvel, J. (1996). Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro. JEM 184: 2141-2152 [Abstract] [Full Text]
Sprent, J, Tough, D. (1994). Lymphocyte life-span and memory. Science 265: 1395-1400 [Abstract]
Le Campion, A., Bourgeois, C., Lambolez, F., Martin, B., Leaument, S., Dautigny, N., Tanchot, C., Penit, C., Lucas, B. (2002). Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes. Proc. Natl. Acad. Sci. USA 99: 4538-4543 [Abstract] [Full Text]
Polic, B., Kunkel, D., Scheffold, A., Rajewsky, K. (2001). How alpha beta T cells deal with induced TCRalpha ablation. Proc. Natl. Acad. Sci. USA 98: 8744-8749 [Abstract] [Full Text]