Thymus epithelium induces tissue-specific tolerance

doi:10.1084/jem.177.4.1153

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Thymus epithelium induces tissue-specific tolerance

A Bonomo and P Matzinger
Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892.

Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells.
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