Activin A/erythroid differentiation factor is induced during human monocyte activation

doi:10.1084/jem.176.5.1449

This Article

Full Text (PDF, 442K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Eramaa, M.

Articles by Ritvos, O.

Search for Related Content

PubMed

PubMed Citation

Articles by Eramaa, M.

Articles by Ritvos, O.

Pubmed/NCBI databases

Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Activin A/erythroid differentiation factor is induced during human monocyte activation

M Eramaa, M Hurme, UH Stenman and O Ritvos
Department of Bacteriology and Immunology, University of Helsinki, Finland.

Activin A/erythroid differentiation factor (EDF), a dimeric polypeptide hormone composed of two beta A subunits, regulates growth and erythroid differentiation of human hematopoietic progenitor and erythroleukemia cells. We have identified activated human peripheral blood monocytes as a natural source of activin A/EDF. In these cells, lipopolysaccharide (LPS) induced rapidly the expression of the beta A subunit mRNAs through protein kinase C-dependent transcriptional regulation. The beta A subunit mRNA expression was also increased by 1,25-dihydroxyvitamin D3, an inducer of macrophage maturation of monocytes. Western analysis with an anti-beta A antibody and an erythroid differentiation bioassay confirmed that the conditioned media of LPS-activated monocytes contained the activin A/EDF protein. We suggest that monocyte/macrophage-derived activin A/EDF may not only modulate hematopoiesis but may also act as a mediator molecule in the diverse physiologic and pathogenetic events in which these cells are involved.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Dower, K., Ellis, D. K., Saraf, K., Jelinsky, S. A., Lin, L.-L. (2008). Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide. J. Immunol. 180: 3520-3534 [Abstract] [Full Text]
Robson, N. C., Phillips, D. J., McAlpine, T., Shin, A., Svobodova, S., Toy, T., Pillay, V., Kirkpatrick, N., Zanker, D., Wilson, K., Helling, I., Wei, H., Chen, W., Cebon, J., Maraskovsky, E. (2008). Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production. Blood 111: 2733-2743 [Abstract] [Full Text]
Jones, K. L., Mansell, A., Patella, S., Scott, B. J., Hedger, M. P., de Kretser, D. M., Phillips, D. J. (2007). Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc. Natl. Acad. Sci. USA 104: 16239-16244 [Abstract] [Full Text]
Okuma, Y, O'Connor, A E, Hayashi, T, Loveland, K L, de Kretser, D M, Hedger, M P (2006). Regulated production of activin A and inhibin B throughout the cycle of the seminiferous epithelium in the rat.. J Endocrinol 190: 331-340 [Abstract] [Full Text]
Florio, P., Perrone, S., Luisi, S., Vezzosi, P., Longini, M., Marzocchi, B., Petraglia, F., Buonocore, G. (2006). Increased Plasma Concentrations of Activin A Predict Intraventricular Hemorrhage in Preterm Newborns. Clin. Chem. 52: 1516-1521 [Abstract] [Full Text]
Xu, P., Van Slambrouck, C., Berti-Mattera, L., Hall, A. K. (2005). Activin Induces Tactile Allodynia and Increases Calcitonin Gene-Related Peptide after Peripheral Inflammation. J. Neurosci. 25: 9227-9235 [Abstract] [Full Text]
Martinovic, S., Mazic, S., Kisic, V., Basic, N., Jakic-Razumovic, J., Borovecki, F., Batinic, D., Simic, P., Grgurevic, L., Labar, B., Vukicevic, S. (2004). Expression of Bone Morphogenetic Proteins in Stromal Cells from Human Bone Marrow Long-term Culture. J. Histochem. Cytochem. 52: 1159-1167 [Abstract] [Full Text]
Tannetta, D. S., Muttukrishna, S., Groome, N. P., Redman, C. W. G., Sargent, I. L. (2003). Endothelial Cells and Peripheral Blood Mononuclear Cells Are a Potential Source of Extraplacental Activin A in Preeclampsia. J. Clin. Endocrinol. Metab. 88: 5995-6001 [Abstract] [Full Text]
Funaba, M., Ikeda, T., Ogawa, K., Murakami, M., Abe, M. (2003). Role of activin A in murine mast cells: modulation of cell growth, differentiation, and migration. J. Leukoc. Biol. 73: 793-801 [Abstract] [Full Text]
Laurikkala, J., Pispa, J., Jung, H.-S., Nieminen, P., Mikkola, M., Wang, X., Saarialho-Kere, U., Galceran, J., Grosschedl, R., Thesleff, I. (2003). Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129: 2541-2553 [Abstract] [Full Text]
Shav-Tal, Y., Zipori, D. (2002). The Role of Activin A in Regulation of Hemopoiesis. Stem Cells 20: 493-500 [Abstract] [Full Text]
Coombes, B. K., Mahony, J. B. (2001). cDNA Array Analysis of Altered Gene Expression in Human Endothelial Cells in Response to Chlamydia pneumoniae Infection. Infect. Immun. 69: 1420-1427 [Abstract] [Full Text]
Jones, R.L., Salamonsen, L.A., Critchley, H.O.D., Rogers, P.A.W., Affandi, B., Findlay, J.K. (2000). Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregnancy and in women using progestin-only contraception. Mol Hum Reprod 6: 1107-1117 [Abstract] [Full Text]
Ogawa, K., Funaba, M., Mathews, L. S., Mizutani, T. (2000). Activin A Stimulates Type IV Collagenase (Matrix Metalloproteinase-2) Production in Mouse Peritoneal Macrophages. J. Immunol. 165: 2997-3003 [Abstract] [Full Text]
Kozaki, K., Akishita, M., Eto, M., Yoshizumi, M., Toba, K., Inoue, S., Ishikawa, M., Hashimoto, M., Kodama, T., Yamada, N., Orimo, H., Ouchi, Y. (1997). Role of Activin-A and Follistatin in Foam Cell Formation of THP-1 Macrophages. Arterioscler. Thromb. Vasc. Bio. 17: 2389-2394 [Abstract] [Full Text]