The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 176, 915-918, Copyright © 1992 by Rockefeller University Press

ARTICLES

Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides

FF Santos-Benito, A Fernandez-Mayoralas, M Martin-Lomas and M Nieto-Sampedro
Instituto Cajal, Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain.

A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was cytostatic for primary astrocytes in culture, but cytotoxic for fast proliferating cell lines.
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