CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation

doi:10.1084/jem.175.4.1131

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Fraser, J. D.
	Articles by Weiss, A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Fraser, J. D.
	Articles by Weiss, A.


Social Bookmarking

	What's this?

ARTICLES

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation

JD Fraser, ME Newton and A Weiss
Howard Hughes Medical Institute, University of California, San Francisco 94143.

Activation of an immune response requires intercellular contact between T lymphocytes and antigen-presenting cells (APC). Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal transduction, but T cell activation appears to require the induction of a second costimulatory signal transduction pathway. Recent studies suggest that interaction of CD28 with B7 on APC might deliver such a costimulatory signal. To investigate the role of CD28 signal transduction during APC-dependent T cell activation, we have used Staphylococcal enterotoxins (SEs) presented by a B7-positive APC. We used anti-B7 monoclonal antibodies and a mutant interleukin 2 (IL-2) promoter construct, unresponsive to CD28-generated signals, in transient transfection assays to examine the contribution of the CD28-B7 interaction to IL-2 gene activation. These studies indicate that the CD28-regulated signal transduction pathway is activated during SE stimulation of T cells and plays an important role in SE induction of IL-2 gene expression through its influence upon the CD28-responsive element contained within the IL-2 gene promoter. This effect is particularly profound in the activation of the IL-2 gene in peripheral blood T cells.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Sullivan, B. M., Coscoy, L. (2008). Downregulation of the T-Cell Receptor Complex and Impairment of T-Cell Activation by Human Herpesvirus 6 U24 Protein. J. Virol. 82: 602-608 [Abstract] [Full Text]
Cismasiu, V. B., Ghanta, S., Duque, J., Albu, D. I., Chen, H.-M., Kasturi, R., Avram, D. (2006). BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood 108: 2695-2702 [Abstract] [Full Text]
Mesel-Lemoine, M., Cherai, M., Le Gouvello, S., Guillot, M., Leclercq, V., Klatzmann, D., Thomas-Vaslin, V., Lemoine, F. M. (2006). Initial depletion of regulatory T cells: the missing solution to preserve the immune functions of T lymphocytes designed for cell therapy. Blood 107: 381-388 [Abstract] [Full Text]
Vu, M. D., Amanullah, F., Li, Y., Demirci, G., Sayegh, M. H., Li, X. C. (2004). Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection. J. Immunol. 173: 214-221 [Abstract] [Full Text]
Kuhne, M. R., Lin, J., Yablonski, D., Mollenauer, M. N., Ehrlich, L. I. R., Huppa, J., Davis, M. M., Weiss, A. (2003). Linker for Activation of T Cells, {zeta}-Associated Protein-70, and Src Homology 2 Domain-Containing Leukocyte Protein-76 are Required for TCR-Induced Microtubule-Organizing Center Polarization. J. Immunol. 171: 860-866 [Abstract] [Full Text]
Attema, J. L., Reeves, R., Murray, V., Levichkin, I., Temple, M. D., Tremethick, D. J., Shannon, M. F. (2002). The Human IL-2 Gene Promoter Can Assemble a Positioned Nucleosome That Becomes Remodeled Upon T Cell Activation. J. Immunol. 169: 2466-2476 [Abstract] [Full Text]
Rajagopalan, G., Smart, M. K., Marietta, E. V., David, C. S. (2002). Staphylococcal enterotoxin B-induced activation and concomitant resistance to cell death in CD28-deficient HLA-DQ8 transgenic mice. Int Immunol 14: 801-812 [Abstract] [Full Text]
Demirci, G., Gao, W., Zheng, X. X., Malek, T. R., Strom, T. B., Li, X. C. (2002). On CD28/CD40 Ligand Costimulation, Common {gamma}-Chain Signals, and the Alloimmune Response. J. Immunol. 168: 4382-4390 [Abstract] [Full Text]
Krakauer, T. (2000). Coordinate Suppression of Superantigen-Induced Cytokine Production and T-Cell Proliferation by a Small Nonpeptidic Inhibitor of Class II Major Histocompatibility Complex and CD4 Interaction. Antimicrob. Agents Chemother. 44: 1067-1069 [Abstract] [Full Text]
Gonsky, R., Deem, R. L., Lee, D. H., Chen, A., Targan, S. R. (1999). CD28 Costimulation Augments IL-2 Secretion of Activated Lamina Propria T Cells by Increasing mRNA Stability Without Enhancing IL-2 Gene Transactivation. J. Immunol. 162: 6621-6629 [Abstract] [Full Text]
Weng, C.-F., Zhao, W., Fegeding, K. V., Komisar, J. L., Tseng, J. (1999). Resistance of staphylococcal enterotoxin B- induced proliferation and apoptosis to the effects of dexamethasone in mouse lymphocyte cultures. Int Immunol 11: 787-801 [Abstract] [Full Text]
Shapiro, V. S., Mollenauer, M. N., Weiss, A. (1998). Cutting Edge: Nuclear Factor of Activated T Cells and AP-1 Are Insufficient for IL-2 Promoter Activation: Requirement for CD28 Up-Regulation of RE/AP. J. Immunol. 161: 6455-6458 [Abstract] [Full Text]
Lu, J., Philpott, D. J., Saunders, P. R., Perdue, M. H., Yang, P.-C., McKay, D. M. (1998). Epithelial Ion Transport and Barrier Abnormalities Evoked by Superantigen-Activated Immune Cells Are Inhibited by Interleukin-10 but Not Interleukin-4. J. Pharmacol. Exp. Ther. 287: 128-136 [Abstract] [Full Text]
Chang, J.-H., Pratt, J. C., Sawasdikosol, S., Kapeller, R., Burakoff, S. J. (1998). The Small GTP-Binding Protein Rho Potentiates AP-1 Transcription in T Cells. Mol. Cell. Biol. 18: 4986-4993 [Abstract] [Full Text]
Butscher, W. G., Powers, C., Olive, M., Vinson, C., Gardner, K. (1998). Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2. J. Biol. Chem. 273: 552-560 [Abstract] [Full Text]
Rivera-Walsh, I., Cvijic, M. E., Xiao, G., Sun, S.-C. (2000). The NF-kappa B Signaling Pathway Is Not Required for Fas Ligand Gene Induction but Mediates Protection from Activation-induced Cell Death. J. Biol. Chem. 275: 25222-25230 [Abstract] [Full Text]