The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 175, 1027-1032, Copyright © 1992 by Rockefeller University Press

ARTICLES

Localization of major histocompatibility complex class I and II mRNA in human first-trimester chorionic villi by in situ hybridization

JA Lata, RS Tuan, KJ Shepley, MM Mulligan, LG Jackson and JB Smith
Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

Maternal immune recognition of pregnancy occurs despite the nonexpression of classical major histocompatibility complex (MHC) antigenic determinants by chorionic villous trophoblast, which comprise the major surface area where maternal blood contacts fetal-derived cells. cDNA-mRNA in situ hybridization was used to probe expression of transcripts corresponding to nonpolymorphic MHC determinants in first- trimester chorionic villus samples. The HLA-B7 probe hybridization signals were localized to syncytiotrophoblast and to cells of the mesenchyme but not to villous cytotrophoblast. HLA-G mRNA was found only in syncytiotrophoblast. A DR beta clone hybridized to both villous cytotrophoblast and syncytiotrophoblast. The results suggest that expression of trophoblast class I and class II determinants early in gestation (10 wk) may be regulated by posttranscriptional events. This also suggests the potential for maternal antifetal alloimmune responses.
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