Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis

doi:10.1084/jem.173.3.599

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Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis

K Miyake, IL Weissman, JS Greenberger and PW Kincade
Oklahoma Medical Research Foundation, Oklahoma City 73104.

Adhesion molecules are probably required for retention of maturing lymphocyte precursors in bone marrow, where they closely interact with and are dependent on stromal cells. Lymphomyeloid cell lines avidly adhere to cloned stromal cell lines in culture and screening pairs of these resulted in a selection strategy for a new monoclonal antibody to a leukocyte adhesion molecule. Immunoprecipitation analyses and comparison to a previously described antibody showed that it recognizes the alpha 4 chain of the integrin, VLA-4. This antibody totally inhibited lymphopoiesis and retarded myelopoiesis in long-term bone marrow cultures. A similar selection strategy resulted in two additional antibodies which define a single 100-kD species on stromal cells. This stromal cell adhesion molecule is a potential counter- receptor/ligand for VLA-4 on murine lympho-myeloid cells. Our findings suggest a new role for VLA-4 in lymphoid progenitor-microenvironment interactions. Recognition molecules that function in cell migration and inflammation in peripheral tissues may be important for steady-state lymphopoiesis within bone marrow.
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Price, A. A., Cumberbatch, M., Kimber, I., Ager, A. (1997). alpha 6 Integrins Are Required for Langerhans Cell Migration from the Epidermis. JEM 186: 1725-1735 [Abstract] [Full Text]
Begley, C.G., Basser, R., Mansfield, R., Thomson, B., Parker, W.R.L., Layton, J., To, B., Cebon, J., Sheridan, W.P., Fox, R.M., Green, M.D. (1997). Enhanced Levels and Enhanced Clonogenic Capacity of Blood Progenitor Cells Following Administration of Stem Cell Factor Plus Granulocyte Colony-Stimulating Factor to Humans. Blood 90: 3378-3389 [Abstract] [Full Text]
Oritani, K., Kanakura, Y., Aoyama, K., Yokota, T., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Tomiyama, Y., Matsuzawa, Y., Kincade, P. W. (1997). Matrix Glycoprotein SC1/ECM2 Augments B Lymphopoiesis. Blood 90: 3404-3413 [Abstract] [Full Text]
Schofield, K. P., Rushton, G., Humphries, M. J., Dexter, T. M., Gallagher, J. T. (1997). Influence of Interleukin-3 and Other Growth Factors on alpha 4beta 1 Integrin-Mediated Adhesion and Migration of Human Hematopoietic Progenitor Cells. Blood 90: 1858-1866 [Abstract] [Full Text]
Henninger, D. D., Gerritsen, M. E., Granger, D. N. (1997). Low-Density Lipoprotein Receptor Knockout Mice Exhibit Exaggerated Microvascular Responses to Inflammatory Stimuli. Circ. Res. 81: 274-281 [Abstract] [Full Text]
Jarvis, L. J., Maguire, J. E., LeBien, T. W. (1997). Contact Between Human Bone Marrow Stromal Cells and B Lymphocytes Enhances Very Late Antigen-4/Vascular Cell Adhesion Molecule-1-Independent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and ERK2 in Stromal Cells. Blood 90: 1626-1635 [Abstract] [Full Text]
Voort, R. v. d., Taher, T. E.I., Keehnen, R. M.J., Smit, L., Groenink, M., Pals, S. T. (1997). Paracrine Regulation of Germinal Center B Cell Adhesion through the c-Met-Hepatocyte Growth Factor/Scatter Factor Pathway. JEM 185: 2121-2131 [Abstract] [Full Text]
Higashi, Y., Moribe, H., Takagi, T., Sekido, R., Kawakami, K., Kikutani, H., Kondoh, H. (1997). Impairment of �T Cell Development in delta EF1 Mutant Mice. JEM 185: 1467-1480 [Abstract] [Full Text]
Roberts, A. W., Foote, S., Alexander, W. S., Scott, C., Robb, L., Metcalf, D. (1997). Genetic Influences Determining Progenitor Cell Mobilization and Leukocytosis Induced by Granulocyte Colony-Stimulating Factor. Blood 89: 2736-2744 [Abstract] [Full Text]
Salomon, D. R., Crisa, L., Mojcik, C. F., Ishii, J. K., Klier, G., Shevach, E. M. (1997). Vascular Cell Adhesion Molecule-1 Is Expressed by Cortical Thymic Epithelial Cells and Mediates Thymocyte Adhesion. Implications for the Function of alpha 4beta 1 (VLA4) Integrin in T-Cell Development. Blood 89: 2461-2471 [Abstract] [Full Text]
Isobe, T., Hisaoka, T., Shimizu, A., Okuno, M., Aimoto, S., Takada, Y., Saito, Y., Takagi, J. (1997). Propolypeptide of von Willebrand Factor Is a Novel Ligand for Very Late Antigen-4 Integrin. J. Biol. Chem. 272: 8447-8453 [Abstract] [Full Text]
Legras, S., Levesque, J.-P., Charrad, R., Morimoto, K., Le Bousse, C., Clay, D., Jasmin, C., Smadja-Joffe, F. (1997). CD44-Mediated Adhesiveness of Human Hematopoietic Progenitors to Hyaluronan Is Modulated by Cytokines. Blood 89: 1905-1914 [Abstract] [Full Text]