Autoantibodies against the multicatalytic proteinase in patients with systemic lupus erythematosus

doi:10.1084/jem.173.2.423

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Autoantibodies against the multicatalytic proteinase in patients with systemic lupus erythematosus

J Arribas, M Luz Rodriguez, R Alvarez-Do Forno and JG Castano
Departamento de Bioquimica, Facultad de Medicina de la UAM, Spain.

Sera from patients with systemic lupus erythematosus contain specific autoantibodies directed against different polypeptide components of the multicatalytic proteinase (also known as proteasome or prosome). These human autoantibodies, in contrast to polyclonal antibodies obtained in rabbits against the purified enzyme, recognize highly conserved epitopes of the multicatalytic proteinase polypeptides from yeast to human.
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