The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 172, 1873-1876, Copyright © 1990 by Rockefeller University Press

ARTICLES

Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells

S Scott, F Pandolfi and JT Kurnick
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 02114.

This report describes a salvage pathway whereby activated T lymphocytes revert to nonproliferating cells in the absence of antigen or mitogenic signals. After the removal of mitogenic cytokines, cultured T lymphocytes cease dividing and rapidly begin to undergo cell death. However, the addition of fibroblasts to interleukin 2 (IL-2)-propagated T cells results in prolonged survival of the previously activated T lymphocytes in the absence of proliferation. The prevention of cell death is also achieved by conditioned medium from the fibroblasts. T lymphocytes cultured with fibroblasts or the conditioned medium retain the ability to be restimulated if mitogenic stimuli are added to the culture. The activity is not accounted for by IL-1-7. The studies suggest a stromal cell-mediated, nonspecific mechanism for survival of primed T lymphocytes in a nonproliferating state.
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