Structure-function relationships among highly diverse T cells that recognize a determinant from influenza virus hemagglutinin

doi:10.1084/jem.172.6.1643

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Structure-function relationships among highly diverse T cells that recognize a determinant from influenza virus hemagglutinin

AH Taylor, AM Haberman, W Gerhard and AJ Caton
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylyvania 19104.

We have analyzed the structural and genetic basis for T cell recognition of the complex formed between antigen and class II products of the major histocompatibility complex by performing sequence analysis of T cell receptors (TCRs) induced in response to the helper T cell site 1 of the influenza virus hemagglutinin. The results demonstrate, first, that structurally highly diverse TCRs can be utilized in recognition of the same antigen/I-Ed complex: 12 of 13 TCRs utilize unique V alpha/V beta gene segment combinations, suggesting that approximately 70 different V alpha/V beta combinations are available to BALB/c mice in response to this determinant. Second, comparison of these sequences with the ability of each hybridoma to recognize a panel of peptide analogues suggests that alpha and beta chains of these TCRs frequently determine specificity for the NH2-terminal and the COOH terminal portions, respectively, of the site 1 determinant.
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