Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

doi:10.1084/jem.172.6.1535

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Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

M Clauss, M Gerlach, H Gerlach, J Brett, F Wang, PC Familletti, YC Pan, JV Olander, DT Connolly and D Stern
Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032.

Systemic infusion of low concentrations of tumor necrosis factor/cachectin (TNF) into mice that bear TNF-sensitive tumors leads to activation of coagulation, fibrin formation, and occlusive thrombosis exclusively within the tumor vascular bed. To identify mechanisms underlying the localization of this vascular procoagulant response, a tumor-derived polypeptide has been purified to homogeneity from supernatants of murine methylcholanthrene A-induced fibrosarcomas that induces endothelial tissue factor synthesis and expression (half- maximal response at approximately 300 pM), and augments the procoagulant response to TNF in a synergistic fashion. This tumor- derived polypeptide was identified as the murine homologue of vascular permeability factor (VPF) based on similar mobility on SDS-PAGE, an homologous NH2-terminal amino acid sequence, and recognition by a monospecific antibody to guinea pig VPF. In addition, VPF was shown to induce monocyte activation, as evidenced by expression of tissue factor. Finally, VPF was shown to induce monocyte chemotaxis across collagen membranes and endothelial cell monolayers. Taken together, these results indicate that VPF can modulate the coagulant properties of endothelium and monocytes, and can promote monocyte migration into the tumor bed. This suggests one mechanism through which tumor-derived mediators can alter properties of the vessel wall.
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Doi, K., Noiri, E., Nakao, A., Fujita, T., Kobayashi, S., Tokunaga, K. (2006). Functional Polymorphisms in the Vascular Endothelial Growth Factor Gene Are Associated with Development of End-Stage Renal Disease in Males. J. Am. Soc. Nephrol. 17: 823-830 [Abstract] [Full Text]
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Howell, W M, Ali, S, Rose-Zerilli, M J, Ye, S (2005). VEGF polymorphisms and severity of atherosclerosis. J. Med. Genet. 42: 485-490 [Abstract] [Full Text]
Seipelt, R. G., Backer, C. L., Mavroudis, C., Stellmach, V., Cornwell, M., Seipelt, I. M., Schoendube, F. A., Crawford, S. E. (2005). Osteopontin expression and adventitial angiogenesis induced by local vascular endothelial growth factor 165 reduces experimental aortic calcification. J. Thorac. Cardiovasc. Surg. 129: 773-781 [Abstract] [Full Text]
Reinhardt, B., Schaarschmidt, P., Bossert, A., Luske, A., Finkenzeller, G., Mertens, T., Michel, D. (2005). Upregulation of functionally active vascular endothelial growth factor by human cytomegalovirus. J. Gen. Virol. 86: 23-30 [Abstract] [Full Text]
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Ferrara, N. (2004). Vascular Endothelial Growth Factor: Basic Science and Clinical Progress. Endocr. Rev. 25: 581-611 [Abstract] [Full Text]
Hesser, B. A., Liang, X. H., Camenisch, G., Yang, S., Lewin, D. A., Scheller, R., Ferrara, N., Gerber, H.-P. (2004). Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood 104: 149-158 [Abstract] [Full Text]
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Yoshida, S., Yoshida, A., Ishibashi, T., Elner, S. G., Elner, V. M. (2003). Role of MCP-1 and MIP-1{alpha} in retinal neovascularization during postischemic inflammation in a mouse model of retinal neovascularization. J. Leukoc. Biol. 73: 137-144 [Abstract] [Full Text]
Koyama, S., Sato, E., Tsukadaira, A., Haniuda, M., Numanami, H., Kurai, M., Nagai, S., Izumi, T. (2002). Vascular endothelial growth factor mRNA and protein expression in airway epithelial cell lines in vitro. Eur Respir J 20: 1449-1456 [Abstract] [Full Text]
Dvorak, H. F. (2002). Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy. JCO 20: 4368-4380 [Abstract] [Full Text]
Kuenen, B.C., Levi, M., Meijers, J.C.M., Kakkar, A.K., van Hinsbergh, V.W.M., Kostense, P.J., Pinedo, H.M., Hoekman, K. (2002). Analysis of Coagulation Cascade and Endothelial Cell Activation During Inhibition of Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Pathway in Cancer Patients. Arterioscler. Thromb. Vasc. Bio. 22: 1500-1505 [Abstract] [Full Text]
Koyama, S., Sato, E., Haniuda, M., Numanami, H., Nagai, S., Izumi, T. (2002). Decreased Level of Vascular Endothelial Growth Factor in Bronchoalveolar Lavage Fluid of Normal Smokers and Patients with Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 166: 382-385 [Abstract] [Full Text]
Rice, A, Quinn, C M (2002). Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast. J. Clin. Pathol. 55: 569-574 [Abstract] [Full Text]
Jussila, L., Alitalo, K. (2002). Vascular Growth Factors and Lymphangiogenesis. Physiol. Rev. 82: 673-700 [Abstract] [Full Text]
Lavie, L., Kraiczi, H., Hefetz, A., Ghandour, H., Perelman, A., Hedner, J., Lavie, P. (2002). Plasma Vascular Endothelial Growth Factor in Sleep Apnea Syndrome: Effects of Nasal Continuous Positive Air Pressure Treatment. Am. J. Respir. Crit. Care Med. 165: 1624-1628 [Abstract] [Full Text]
Cotton, J.M., Mathur, A., Hong, Y., Brown, A.S., Martin, J.F., Erusalimsky, J.D. (2002). Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery. Eur Heart J 23: 953-959 [Abstract] [Full Text]
Lemstrom, K. B., Krebs, R., Nykanen, A. I., Tikkanen, J. M., Sihvola, R. K., Aaltola, E. M., Hayry, P. J., Wood, J., Alitalo, K., Yla-Herttuala, S., Koskinen, P. K. (2002). Vascular Endothelial Growth Factor Enhances Cardiac Allograft Arteriosclerosis. Circulation 105: 2524-2530 [Abstract] [Full Text]
Adamis, A P (2002). Is diabetic retinopathy an inflammatory disease?. Br. J. Ophthalmol. 86: 363-365 [Full Text]
Leek, R. D., Talks, K. L., Pezzella, F., Turley, H., Campo, L., Brown, N. S., Bicknell, R., Taylor, M., Gatter, K. C., Harris, A. L. (2002). Relation of Hypoxia-inducible Factor-2{alpha} (HIF-2{alpha}) Expression in Tumor-infiltrative Macrophages to Tumor Angiogenesis and the Oxidative Thymidine Phosphorylase Pathway in Human Breast Cancer. Cancer Res. 62: 1326-1329 [Abstract] [Full Text]
Joussen, A. M., Poulaki, V., Qin, W., Kirchhof, B., Mitsiades, N., Wiegand, S. J., Rudge, J., Yancopoulos, G. D., Adamis, A. P. (2002). Retinal Vascular Endothelial Growth Factor Induces Intercellular Adhesion Molecule-1 and Endothelial Nitric Oxide Synthase Expression and Initiates Early Diabetic Retinal Leukocyte Adhesion in Vivo. Am. J. Pathol. 160: 501-509 [Abstract] [Full Text]
Crowther, M., Brown, N. J., Bishop, E. T., Lewis, C. E. (2001). Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J. Leukoc. Biol. 70: 478-490 [Abstract] [Full Text]
Epstein, S. E., Kornowski, R., Fuchs, S., Dvorak, H. F. (2001). Angiogenesis Therapy : Amidst the Hype, the Neglected Potential for Serious Side Effects. Circulation 104: 115-119 [Full Text]
Celletti, F. L., Hilfiker, P. R., Ghafouri, P., Dake, M. D. (2001). Effect of human recombinant vascular endothelial growth factor165 on progression of atherosclerotic plaque. J Am Coll Cardiol 37: 2126-2130 [Abstract] [Full Text]
Kini, A. R., Peterson, L. C., Tallman, M. S., Lingen, M. W. (2001). Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid. Blood 97: 3919-3924 [Abstract] [Full Text]
Tabibiazar, R, Rockson, S.G (2001). Angiogenesis and the ischaemic heart. Eur Heart J 22: 903-918
Zachary, I. (2001). Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am. J. Physiol. Cell Physiol. 280: C1375-C1386 [Abstract] [Full Text]
Inoue, M., Itoh, H., Tanaka, T., Chun, T.-H., Doi, K., Fukunaga, Y., Sawada, N., Yamshita, J., Masatsugu, K., Saito, T., Sakaguchi, S., Sone, M., Yamahara, K.-i., Yurugi, T., Nakao, K. (2001). Oxidized LDL Regulates Vascular Endothelial Growth Factor Expression in Human Macrophages and Endothelial Cells Through Activation of Peroxisome Proliferator-Activated Receptor-{{gamma}}. Arterioscler. Thromb. Vasc. Bio. 21: 560-566 [Abstract] [Full Text]
Clauss, M., Sunderkotter, C., Sveinbjornsson, B., Hippenstiel, S., Willuweit, A., Marino, M., Haas, E., Seljelid, R., Scheurich, P., Suttorp, N., Grell, M., Risau, W. (2001). A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability. Blood 97: 1321-1329 [Abstract] [Full Text]
Zachary, I., Gliki, G. (2001). Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49: 568-581 [Abstract] [Full Text]
Robinson, C., Stringer, S. (2001). The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J. Cell Sci. 114: 853-865 [Abstract]
MECHTCHERIAKOVA, D., SCHABBAUER, G., LUCERNA, M., CLAUSS, M., DE MARTIN, R., BINDER, B. R., HOFER, E. (2001). Specificity, diversity, and convergence in VEGF and TNF-{alpha} signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells. FASEB J. 15: 230-242 [Abstract] [Full Text]
Murray, J. C., Barnett, G., Tas, M., Jakobsen, A., Brown, J., Powe, D., Clelland, C. (2000). Immunohistochemical Analysis of Endothelial-Monocyte-Activating Polypeptide-II Expression in Vivo. Am. J. Pathol. 157: 2045-2053 [Abstract] [Full Text]
Vuorela, P., Andersson, S., Carpen, O., Ylikorkala, O., Halmesmaki, E. (2000). Unbound vascular endothelial growth factor and its receptors in breast, human milk, and newborn intestine. Am. J. Clin. Nutr. 72: 1196-1201 [Abstract] [Full Text]
Bausero, P., Ben-Mahdi, M.-H., Mazucatelli, J.-P., Bloy, C., Perrot-Applanat, M. (2000). Vascular endothelial growth factor is modulated in vascular muscle cells by estradiol, tamoxifen, and hypoxia. Am. J. Physiol. Heart Circ. Physiol. 279: H2033-H2042 [Abstract] [Full Text]
Saita, N., Fujiwara, N., Yano, I., Soejima, K., Kobayashi, K. (2000). Trehalose 6,6'-Dimycolate (Cord Factor) of Mycobacterium tuberculosis Induces Corneal Angiogenesis in Rats. Infect. Immun. 68: 5991-5997 [Abstract] [Full Text]
Philipp, W., Speicher, L., Humpel, C. (2000). Expression of Vascular Endothelial Growth Factor and Its Receptors in Inflamed and Vascularized Human Corneas. IOVS 41: 2514-2522 [Abstract] [Full Text]
Senger, D. R., Van De Water, L. (2000). VEGF Expression by Epithelial and Stromal Cell Compartments : Resolving a Controversy. Am. J. Pathol. 157: 1-3 [Full Text]
THOMAS, S., VANUYSTEL, J., GRUDEN, G., RODRÍGUEZ, V., BURT, D., GNUDI, L., HARTLEY, B., VIBERTI, G. (2000). Vascular Endothelial Growth Factor Receptors in Human Mesangium in Vitro and in Glomerular Disease. J. Am. Soc. Nephrol. 11: 1236-1243 [Abstract] [Full Text]
Zachary, I., Mathur, A., Yla-Herttuala, S., Martin, J. (2000). Vascular Protection : A Novel Nonangiogenic Cardiovascular Role for Vascular Endothelial Growth Factor. Arterioscler. Thromb. Vasc. Bio. 20: 1512-1520 [Abstract] [Full Text]
Koukourakis, M. I., Giatromanolaki, A., Thorpe, P. E., Brekken, R. A., Sivridis, E., Kakolyris, S., Georgoulias, V., Gatter, K. C., Harris, A. L. (2000). Vascular Endothelial Growth Factor/KDR Activated Microvessel Density versus CD31 Standard Microvessel Density in Non-Small Cell Lung Cancer. Cancer Res. 60: 3088-3095 [Abstract] [Full Text]
Lu, J., Kasama, T., Kobayashi, K., Yoda, Y., Shiozawa, F., Hanyuda, M., Negishi, M., Ide, H., Adachi, M. (2000). Vascular Endothelial Growth Factor Expression and Regulation of Murine Collagen-Induced Arthritis. J. Immunol. 164: 5922-5927 [Abstract] [Full Text]
Vidal, F., Aragones, J., Alfranca, A., de Landazuri, M. O. (2000). Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1. Blood 95: 3387-3395 [Abstract] [Full Text]
Guo, D.-Q., Wu, L.-W., Dunbar, J. D., Ozes, O. N., Mayo, L. D., Kessler, K. M., Gustin, J. A., Baerwald, M. R., Jaffe, E. A., Warren, R. S., Donner, D. B. (2000). Tumor Necrosis Factor Employs a Protein-tyrosine Phosphatase to Inhibit Activation of KDR and Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation. J. Biol. Chem. 275: 11216-11221 [Abstract] [Full Text]
Sakaguchi, I., Ikeda, N., Nakayama, M., Kato, Y., Yano, I., Kaneda, K. (2000). Trehalose 6,6'-Dimycolate (Cord Factor) Enhances Neovascularization through Vascular Endothelial Growth Factor Production by Neutrophils and Macrophages. Infect. Immun. 68: 2043-2052 [Abstract] [Full Text]
Otani, A., Takagi, H., Oh, H., Suzuma, K., Matsumura, M., Ikeda, E., Honda, Y. (2000). Angiotensin II-Stimulated Vascular Endothelial Growth Factor Expression in Bovine Retinal Pericytes. IOVS 41: 1192-1199 [Abstract] [Full Text]
Clauss, M., Schaper, W. (2000). Vascular Endothelial Growth Factor : A Jack-of-All-Trades or a Nonspecific Stress Gene?. Circ. Res. 86: 251-252 [Full Text]
Kornowski, R., Fuchs, S., Leon, M. B., Epstein, S. E. (2000). Delivery Strategies to Achieve Therapeutic Myocardial Angiogenesis. Circulation 101: 454-458 [Abstract] [Full Text]
Li, W, Keller, G (2000). VEGF nuclear accumulation correlates with phenotypical changes in endothelial cells. J. Cell Sci. 113: 1525-1534 [Abstract]
Rosmorduc, O., Wendum, D., Corpechot, C., Galy, B., Sebbagh, N., Raleigh, J., Housset, C., Poupon, R. (1999). Hepatocellular Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Angiogenesis in Experimental Biliary Cirrhosis. Am. J. Pathol. 155: 1065-1073 [Abstract] [Full Text]
Schaper, W., Buschmann, I. (1999). Arteriogenesis, the good and bad of it. Eur Heart J 20: 1297-1299
Schaper, W., Buschmann, I. (1999). Arteriogenesis, the good and bad of it. Cardiovasc Res 43: 835-837 [Full Text]
Schwarz, M. A., Kandel, J., Brett, J., Li, J., Hayward, J., Schwarz, R. E., Chappey, O., Wautier, J.-L., Chabot, J., Gerfo, P. L., Stern, D. (1999). Endothelial-Monocyte Activating Polypeptide II, A Novel Antitumor Cytokine that Suppresses Primary and Metastatic Tumor Growth and Induces Apoptosis in Growing Endothelial Cells. JEM 190: 341-354 [Abstract] [Full Text]
Otani, A., Takagi, H., Oh, H., Koyama, S., Matsumura, M., Honda, Y. (1999). Expressions of Angiopoietins and Tie2 in Human Choroidal Neovascular Membranes. IOVS 40: 1912-1920 [Abstract] [Full Text]
Abe, K., Shoji, M., Chen, J., Bierhaus, A., Danave, I., Micko, C., Casper, K., Dillehay, D. L., Nawroth, P. P., Rickles, F. R. (1999). Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. Proc. Natl. Acad. Sci. USA 96: 8663-8668 [Abstract] [Full Text]
Ascherl, G., Hohenadl, C., Schatz, O., Shumay, E., Bogner, J., Eckhart, L., Tschachler, E., Monini, P., Ensoli, B., Sturzl, M. (1999). Infection With Human Immunodeficiency Virus-1 Increases Expression of Vascular Endothelial Cell Growth Factor in T Cells: Implications for Acquired Immunodeficiency Syndrome-Associated Vasculopathy. Blood 93: 4232-4241 [Abstract] [Full Text]
Gasparri, A., Moro, M., Curnis, F., Sacchi, A., Pagano, S., Veglia, F., Casorati, G., Siccardi, A. G., Dellabona, P., Corti, A. (1999). Tumor Pretargeting with Avidin Improves the Therapeutic Index of Biotinylated Tumor Necrosis Factor {{alpha}} in Mouse Models. Cancer Res. 59: 2917-2923 [Abstract] [Full Text]
Mechtcheriakova, D., Wlachos, A., Holzmuller, H., Binder, B. R., Hofer, E. (1999). Vascular Endothelial Cell Growth Factor-Induced Tissue Factor Expression in Endothelial Cells Is Mediated by EGR-1. Blood 93: 3811-3823 [Abstract] [Full Text]
He, Y., Smith, S. K., Day, K. A., Clark, D. E., Licence, D. R., Charnock-Jones, D. S. (1999). Alternative Splicing of Vascular Endothelial Growth Factor (VEGF)-R1 (FLT-1) pre-mRNA Is Important for the Regulation of VEGF Activity. Mol. Endocrinol. 13: 537-545 [Abstract] [Full Text]
Armesilla, A. L., Lorenzo, E., Gomez del Arco, P., Martinez-Martinez, S., Alfranca, A., Redondo, J. M. (1999). Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression. Mol. Cell. Biol. 19: 2032-2043 [Abstract] [Full Text]
Camera, M., Giesen, P. L. A., Fallon, J., Aufiero, B. M., Taubman, M., Tremoli, E., Nemerson, Y. (1999). Cooperation Between VEGF and TNF-{alpha} Is Necessary for Exposure of Active Tissue Factor on the Surface of Human Endothelial Cells. Arterioscler. Thromb. Vasc. Bio. 19: 531-537 [Abstract] [Full Text]
Corral, C. J., Siddiqui, A., Wu, L., Farrell, C. L., Lyons, D., Mustoe, T. A. (1999). Vascular Endothelial Growth Factor Is More Important Than Basic Fibroblastic Growth Factor During Ischemic Wound Healing. Arch Surg 134: 200-205 [Abstract] [Full Text]
Clark, D. E., Smith, S. K., He, Y., Day, K. A., Licence, D. R., Corps, A. N., Lammoglia, R., Charnock-Jones, D. S. (1998). A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation. Biol. Reprod. 59: 1540-1548 [Abstract] [Full Text]
Inoue, M., Itoh, H., Ueda, M., Naruko, T., Kojima, A., Komatsu, R., Doi, K., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Yamashita, J., Chun, T.-H., Masatsugu, K., Becker, A. E., Nakao, K. (1998). Vascular Endothelial Growth Factor (VEGF) Expression in Human Coronary Atherosclerotic Lesions : Possible Pathophysiological Significance of VEGF in Progression of Atherosclerosis. Circulation 98: 2108-2116 [Abstract] [Full Text]
Knies, U. E., Behrensdorf, H. A., Mitchell, C. A., Deutsch, U., Risau, W., Drexler, H. C.�A., Clauss, M. (1998). Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. Proc. Natl. Acad. Sci. USA 95: 12322-12327 [Abstract] [Full Text]
Metais, C., Li, J., Li, J., Simons, M., Sellke, F. W. (1998). Effects of coronary artery disease on expression and microvascular response to VEGF. Am. J. Physiol. Heart Circ. Physiol. 275: H1411-H1418 [Abstract] [Full Text]
Shen, W Y, Yu, M J T, Barry, C J, Constable, I J, Rakoczy, P E (1998). Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat. Br. J. Ophthalmol. 82: 1063-1071 [Abstract] [Full Text]
Xu, F., Severinghaus, J. W. (1998). Rat brain VEGF expression in alveolar hypoxia: possible role in high-altitude cerebral edema. J. Appl. Physiol. 85: 53-57 [Abstract] [Full Text]
Ramos, M. A., Kuzuya, M., Esaki, T., Miura, S., Satake, S., Asai, T., Kanda, S., Hayashi, T., Iguchi, A. (1998). Induction of Macrophage VEGF in Response to Oxidized LDL and VEGF Accumulation in Human Atherosclerotic Lesions. Arterioscler. Thromb. Vasc. Bio. 18: 1188-1196 [Abstract] [Full Text]
Hippenstiel, S., Krull, M., Ikemann, A., Risau, W., Clauss, M., Suttorp, N. (1998). VEGF induces hyperpermeability by a direct action on endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L678-L684 [Abstract] [Full Text]
Otani, A., Takagi, H., Suzuma, K., Honda, Y. (1998). Angiotensin II Potentiates Vascular Endothelial Growth Factor�Induced Angiogenic Activity in Retinal Microcapillary Endothelial Cells. Circ. Res. 82: 619-628 [Abstract] [Full Text]
Ott, I., Fischer, E. G., Miyagi, Y., Mueller, B. M., Ruf, W. (1998). A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280�. JCB 140: 1241-1253 [Abstract] [Full Text]
Kroll, J., Waltenberger, J. (1997). The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells. J. Biol. Chem. 272: 32521-32527 [Abstract] [Full Text]
Natarajan, R., Bai, W., Lanting, L., Gonzales, N., Nadler, J. (1997). Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 273: H2224-H2231 [Abstract] [Full Text]
Mitola, S., Sozzani, S., Luini, W., Primo, L., Borsatti, A., Weich, H., Bussolino, F. (1997). Tat-Human Immunodeficiency Virus-1 Induces Human Monocyte Chemotaxis by Activation of Vascular Endothelial Growth Factor Receptor-1. Blood 90: 1365-1372 [Abstract] [Full Text]
Abedi, H., Zachary, I. (1997). Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells. J. Biol. Chem. 272: 15442-15451 [Abstract] [Full Text]
SCHLINGEMANN, R. O, VAN HINSBERGH, V. W M (1997). Role of vascular permeability factor/vascular endothelial growth factor in eye disease. Br. J. Ophthalmol. 81: 501-512 [Full Text]
Pendurthi, U. R., Williams, J. T., Rao, L. V. M. (1997). Acidic and Basic Fibroblast Growth Factors Suppress Transcriptional Activation of Tissue Factor and Other Inflammatory Genes in Endothelial Cells. Arterioscler. Thromb. Vasc. Bio. 17: 940-946 [Abstract] [Full Text]
Ferrara, N., Davis-Smyth, T. (1997). The Biology of Vascular Endothelial Growth Factor. Endocr. Rev. 18: 4-25 [Abstract] [Full Text]