The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10

doi:10.1084/jem.170.4.1175

This Article

	Full Text (PDF, 1034K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sastry, K.
	Articles by Ezekowitz, R. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sastry, K.
	Articles by Ezekowitz, R. A.


Social Bookmarking

	What's this?

ARTICLES

The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10

K Sastry, GA Herman, L Day, E Deignan, G Bruns, CC Morton and RA Ezekowitz
Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115.

The human mannose-binding protein (MBP) plays a role in first line host defense against certain pathogens. It is an acute phase protein that exists in serum as a multimer of a 32-kD subunit. The NH2 terminus is rich in cysteines that mediate interchain disulphide bonds and stabilize the second collagen-like region. This is followed by a short intervening region, and the carbohydrate recognition domain is found in the COOH-terminal region. Analysis of the human MBP gene reveals that the coding region is interrupted by three introns, and all four exons appear to encode a distinct domain of the protein. It appears that the human MBP gene has evolved by recombination of an ancestral nonfibrillar collagen gene with a gene that encodes carbohydrate recognition, and is therefore similar to the human surfactant SP-A gene and the rat MBP gene. The gene for MBP is located on the long arm of chromosome 10 at 10q11.2-q21, a region that is included in the assignment for the gene for multiple endocrine neoplasia type 2A.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Ma, B. Y., Nakamura, N., Dlabac, V., Naito, H., Yamaguchi, S., Ishikawa, M., Nonaka, M., Ishiguro, M., Kawasaki, N., Oka, S., Kawasaki, T. (2007). Isolation, Cloning, and Characterization of a Novel Phosphomannan-binding Lectin from Porcine Serum. J. Biol. Chem. 282: 12963-12975 [Abstract] [Full Text]
Smithson, A., Munoz, A., Suarez, B., Soto, S. M., Perello, R., Soriano, A., Martinez, J. A., Vila, J., Horcajada, J. P., Mensa, J., Lozano, F. (2007). Association between Mannose-Binding Lectin Deficiency and Septic Shock following Acute Pyelonephritis Due to Escherichia coli. CVI 14: 256-261 [Abstract] [Full Text]
Seyfarth, J., Garred, P., Madsen, H. O. (2005). The 'involution' of mannose-binding lectin. Hum Mol Genet 14: 2859-2869 [Abstract] [Full Text]
Rugonfalvi-Kiss, S., Dosa, E., Madsen, H. O., Endresz, V., Prohaszka, Z., Laki, J., Karadi, I., Gonczol, E., Selmeci, L., Romics, L., Fust, G., Entz, L., Garred, P. (2005). High Rate of Early Restenosis After Carotid Eversion Endarterectomy in Homozygous Carriers of the Normal Mannose-Binding Lectin Genotype. Stroke 36: 944-948 [Abstract] [Full Text]
Whitehouse, J L, Exley, A R, Foweraker, J, Bilton, D (2005). Chronic Burkholderia multivorans bronchial infection in a non-cystic fibrosis individual with mannose binding lectin deficiency. Thorax 60: 168-170 [Abstract] [Full Text]
Gomi, K., Tokue, Y., Kobayashi, T., Takahashi, H., Watanabe, A., Fujita, T., Nukiwa, T. (2004). Mannose-Binding Lectin Gene Polymorphism Is a Modulating Factor in Repeated Respiratory Infections. Chest 126: 95-99 [Abstract] [Full Text]
Larsen, F., Madsen, H. O., Sim, R. B., Koch, C., Garred, P. (2004). Disease-associated Mutations in Human Mannose-binding Lectin Compromise Oligomerization and Activity of the Final Protein. J. Biol. Chem. 279: 21302-21311 [Abstract] [Full Text]
Estabrook, M. M., Jack, D. L., Klein, N. J., Jarvis, G. A. (2004). Mannose-Binding Lectin Binds to Two Major Outer Membrane Proteins, Opacity Protein and Porin, of Neisseria meningitidis. J. Immunol. 172: 3784-3792 [Abstract] [Full Text]
Garred, P., Nielsen, M. A., Kurtzhals, J. A.L., Malhotra, R., Madsen, H. O., Goka, B. Q., Akanmori, B. D., Sim, R. B., Hviid, L. (2003). Mannose-Binding Lectin Is a Disease Modifier in Clinical Malaria and May Function as Opsonin for Plasmodium falciparum- Infected Erythrocytes. Infect. Immun. 71: 5245-5253 [Abstract] [Full Text]
Schmiegelow, K., Garred, P., Lausen, B., Andreassen, B., Petersen, B. L., Madsen, H. O. (2002). Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia. Blood 100: 3757-3760 [Abstract] [Full Text]
Neth, O., Jack, D. L., Johnson, M., Klein, N. J., Turner, M. W. (2002). Enhancement of Complement Activation and Opsonophagocytosis by Complexes of Mannose-Binding Lectin with Mannose-Binding Lectin-Associated Serine Protease After Binding to Staphylococcus aureus. J. Immunol. 169: 4430-4436 [Abstract] [Full Text]
Mullighan, C. G., Heatley, S., Doherty, K., Szabo, F., Grigg, A., Hughes, T. P., Schwarer, A. P., Szer, J., Tait, B. D., Bik To, L., Bardy, P. G. (2002). Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation. Blood 99: 3524-3529 [Abstract] [Full Text]
Koch, A., Melbye, M., Sorensen, P., Homoe, P., Madsen, H. O., Molbak, K., Hansen, C. H., Andersen, L. H., Hahn, G. W., Garred, P. (2001). Acute Respiratory Tract Infections and Mannose-Binding Lectin Insufficiency During Early Childhood. JAMA 285: 1316-1321 [Abstract] [Full Text]
Wright, T. W., Notter, R. H., Wang, Z., Harmsen, A. G., Gigliotti, F. (2001). Pulmonary Inflammation Disrupts Surfactant Function during Pneumocystis carinii Pneumonia. Infect. Immun. 69: 758-764 [Abstract] [Full Text]
Rosseau, S., Hammerl, P., Maus, U., Gunther, A., Seeger, W., Grimminger, F., Lohmeyer, J. (1999). Surfactant Protein A Down-Regulates Proinflammatory Cytokine Production Evoked by Candida albicans in Human Alveolar Macrophages and Monocytes. J. Immunol. 163: 4495-4502 [Abstract] [Full Text]
Akiyama, J., Volik, S. V., Plajzer-Frick, I., Prince, A., Sago, H., Weier, H.-U. G., Vanderbilt, J. N., Hawgood, S., Poulain, F. R. (1999). Characterization of the Mouse Collectin Gene Locus. Am. J. Respir. Cell Mol. Bio. 21: 193-199 [Abstract] [Full Text]
Ohtani, K., Suzuki, Y., Eda, S., Kawai, T., Kase, T., Yamazaki, H., Shimada, T., Keshi, H., Sakai, Y., Fukuoh, A., Sakamoto, T., Wakamiya, N. (1999). Molecular Cloning of a Novel Human Collectin from Liver (CL-L1). J. Biol. Chem. 274: 13681-13689 [Abstract] [Full Text]
Lawson, P. R., Perkins, V. C., Holmskov, U., Reid, K. B.�M. (1999). Genomic Organization of the Mouse Gene for Lung Surfactant Protein D. Am. J. Respir. Cell Mol. Bio. 20: 953-963 [Abstract] [Full Text]
Madsen, H. O., Satz, M. L., Hogh, B., Svejgaard, A., Garred, P. (1998). Different Molecular Events Result in Low Protein Levels of Mannan-Binding Lectin in Populations from Southeast Africa and South America. J. Immunol. 161: 3169-3175 [Abstract] [Full Text]
Suankratay, C., Zhang, X.-H., Zhang, Y., Lint, T. F., Gewurz, H. (1998). Requirement for the Alternative Pathway as Well as C4 and C2 in Complement-Dependent Hemolysis Via the Lectin Pathway. J. Immunol. 160: 3006-3013 [Abstract] [Full Text]
Hoover, R. R., Floros, J. (1998). Organization of the Human SP-A and SP-D Loci at 10q22-q23 . Physical and Radiation Hybrid Mapping Reveal Gene Order and Orientation. Am. J. Respir. Cell Mol. Bio. 18: 353-362 [Abstract] [Full Text]