A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes

doi:10.1084/jem.170.3.1051

This Article

	Full Text (PDF)
	Alert me when this article is cited

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Gould, K.
	Articles by Townsend, A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Gould, K.
	Articles by Townsend, A.


Social Bookmarking

	What's this?

ARTICLES

A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes

K Gould, J Cossins, J Bastin, GG Brownlee and A Townsend
Sir William Dunn School of Pathology, University of Oxford, United Kingdom.

A recombinant vaccinia has been designed to express amino acids 366-379 of influenza nucleoprotein, previously shown to be the minimal epitope recognized by a class I-restricted cytotoxic T cell clone. Target cells infected with the recombinant vaccinia virus expressing this peptide are recognized by CTL as efficiently as target cells expressing the complete nucleoprotein. The results imply the existence of a peptide transport system that constitutively passes the products of degraded proteins from the cytoplasm into a membrane-bound compartment of the cell.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Fischer, M. A., Tscharke, D. C., Donohue, K. B., Truckenmiller, M. E., Norbury, C. C. (2007). Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming. J. Gen. Virol. 88: 2378-2386 [Abstract] [Full Text]
SUPHAVILAI, C., LOOAREESUWAN, S., GOOD, M. F. (2004). ANALYSIS OF CIRCUMSPOROZOITE PROTEIN-SPECIFIC IMMUNE RESPONSES FOLLOWING RECENT INFECTION WITH PLASMODIUM VIVAX. Am J Trop Med Hyg 71: 29-39 [Abstract] [Full Text]
Moss, B (1991). Vaccinia virus: a tool for research and vaccine development. Science 252: 1662-1667 [Abstract]
Townsend, A., Ohlen, C., Foster, L., Bastin, J., Ljunggren, H.-G., Karre, K. (1989). A Mutant Cell in Which Association of Class I Heavy and Light Chains Is Induced by Viral Peptides. Cold Spring Harb Symp Quant Biol 54: 299-308 [Abstract]