A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus

doi:10.1084/jem.169.1.185

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A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus

RA Ezekowitz, M Kuhlman, JE Groopman and RA Byrn
Division of Hematology/Oncology, Harvard Medical School, Boston, Massachusetts.

In vitro infection by the human immunodeficiency virus (HIV) of CD4+ H9 lymphoblasts is inhibited by a mannose-binding protein (MBP) purified from human serum. In addition, MBP is able to selectively bind to HIV- infected H9 cells and HIV-infected cells from the monocyte cell line U937. These results indicate MBP most likely recognizes high mannose glycans known to be present on gp120 in the domain that is recognized by CD4 and thereby inhibits viral entry to susceptible cells. In support of this contention, recombinant gp120 binds directly to MBP; the binding is saturable, mannan inhibitable, removed by N-glycanase treatment, and dependent on divalent cations.
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Devyatyarova-Johnson, M., Rees, I. H., Robertson, B. D., Turner, M. W., Klein, N. J., Jack, D. L. (2000). The Lipopolysaccharide Structures of Salmonella enterica Serovar Typhimurium and Neisseria gonorrhoeae Determine the Attachment of Human Mannose-Binding Lectin to Intact Organisms. Infect. Immun. 68: 3894-3899 [Abstract] [Full Text]
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Neth, O., Jack, D. L., Dodds, A. W., Holzel, H., Klein, N. J., Turner, M. W. (2000). Mannose-Binding Lectin Binds to a Range of Clinically Relevant Microorganisms and Promotes Complement Deposition. Infect. Immun. 68: 688-693 [Abstract] [Full Text]
Ohtani, K., Suzuki, Y., Eda, S., Kawai, T., Kase, T., Yamazaki, H., Shimada, T., Keshi, H., Sakai, Y., Fukuoh, A., Sakamoto, T., Wakamiya, N. (1999). Molecular Cloning of a Novel Human Collectin from Liver (CL-L1). J. Biol. Chem. 274: 13681-13689 [Abstract] [Full Text]
LeVine, A. M., Kurak, K. E., Wright, J. R., Watford, W. T., Bruno, M. D., Ross, G. F., Whitsett, J. A., Korfhagen, T. R. (1999). Surfactant Protein-A Binds Group B Streptococcus Enhancing Phagocytosis and Clearance from Lungs of Surfactant Protein-A-Deficient Mice. Am. J. Respir. Cell Mol. Bio. 20: 279-286 [Abstract] [Full Text]
Ma, Y., Uemura, K., Oka, S., Kozutsumi, Y., Kawasaki, N., Kawasaki, T. (1999). Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: Mannan-binding proteindependent cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA 96: 371-375 [Abstract] [Full Text]
LeVine, A. M., Kurak, K. E., Bruno, M. D., Stark, J. M., Whitsett, J. A., Korfhagen, T. R. (1998). Surfactant Protein-A-Deficient Mice Are Susceptible to Pseudomonas aeruginosa Infection. Am. J. Respir. Cell Mol. Bio. 19: 700-708 [Abstract] [Full Text]
Swanson, A. F., Ezekowitz, R. A. B., Lee, A., Kuo, C.-c. (1998). Human Mannose-Binding Protein Inhibits Infection of HeLa Cells by Chlamydia trachomatis. Infect. Immun. 66: 1607-1612 [Abstract] [Full Text]
Hartshorn, K. L., White, M. R., Shepherd, V., Reid, K., Jensenius, J. C., Crouch, E. C. (1997). Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins. Am. J. Physiol. Lung Cell. Mol. Physiol. 273: L1156-L1166 [Abstract] [Full Text]
Matsushita, M., Endo, Y., Taira, S., Sato, Y., Fujita, T., Ichikawa, N., Nakata, M., Mizuochi, T. (1996). A Novel Human Serum Lectin with Collagen- and Fibrinogen-like Domains That Functions as an Opsonin. J. Biol. Chem. 271: 2448-2454 [Abstract] [Full Text]
Weis, W., Kahn, R, Fourme, R, Drickamer, K, Hendrickson, W. (1991). Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing. Science 254: 1608-1615 [Abstract]