Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies

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Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies

HM Cherwinski, JH Schumacher, KD Brown and TR Mosmann
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304.

Lymphokine synthesis patterns of a panel of 19 T cell clones have been evaluated, using mRNA hybridization methods to examine 11 different mRNAs induced by Con A. The two types of CD4+ Th cell clone described previously were clearly distinguished by this procedure, and the differences between the two types have now been extended to six induced products. With minor exceptions, only Th1 clones synthesized mRNA for IL-2, IFN-gamma, and lymphotoxin, and only Th2 clones synthesized mRNA for IL-4, IL-5, and another induced gene, P600. Four more induced products were expressed preferentially but not uniquely by one or another type of clone: mRNAs for GM-CSF, TNF, and another induced, secreted product (TY5) were produced in larger amounts by Th1 clones, whereas preproenkephalin was preferentially expressed by Th2 clones. IL- 3 was produced in similar amounts by both types of clone. mAbs were used to establish three bioassays that were functionally monospecific for IL-2, IL-3, and IL-4, and a new anti-IFN gamma mAb, XMG1.2, was used to establish an ELISA for IFN-gamma. These four assays were used to show that secreted protein and mRNA levels correlated well for all cell lines. The implications of these findings for normal T cells are discussed.
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Tam, R. C., Lim, C., Bard, J., Pai, B. (1999). Contact Hypersensitivity Responses Following Ribavirin Treatment In Vivo Are Influenced by Type 1 Cytokine Polarization, Regulation of IL-10 Expression, and Costimulatory Signaling. J. Immunol. 163: 3709-3717 [Abstract] [Full Text]
Scanga, C. A., Mohan, V. P., Joseph, H., Yu, K., Chan, J., Flynn, J. L. (1999). Reactivation of Latent Tuberculosis: Variations on the Cornell Murine Model. Infect. Immun. 67: 4531-4538 [Abstract] [Full Text]
Trembleau, S., Penna, G., Gregori, S., Chapman, H. D., Serreze, D. V., Magram, J., Adorini, L. (1999). Pancreas-Infiltrating Th1 Cells and Diabetes Develop in IL-12-Deficient Nonobese Diabetic Mice. J. Immunol. 163: 2960-2968 [Abstract] [Full Text]
Caveno, J., Zhang, Y., Motyka, B., Teh, S.-J., Teh, H.-S. (1999). Functional Similarity and Differences Between Selection-Independent CD4-CD8- {alpha}{beta} T Cells and Positively Selected CD8 T Cells Expressing the Same TCR and the Induction of Anergy in CD4-CD8- {alpha}{beta} T Cells in Antigen-Expressing Mice. J. Immunol. 163: 1222-1229 [Abstract] [Full Text]
Mumberg, D., Monach, P. A., Wanderling, S., Philip, M., Toledano, A. Y., Schreiber, R. D., Schreiber, H. (1999). CD4+ T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma. Proc. Natl. Acad. Sci. USA 96: 8633-8638 [Abstract] [Full Text]
Doolan, D. L., Hoffman, S. L. (1999). IL-12 and NK Cells Are Required for Antigen-Specific Adaptive Immunity Against Malaria Initiated by CD8+ T Cells in the Plasmodium yoelii Model. J. Immunol. 163: 884-892 [Abstract] [Full Text]
Cohn, L., Homer, R. J., MacLeod, H., Mohrs, M., Brombacher, F., Bottomly, K. (1999). Th2-Induced Airway Mucus Production Is Dependent on IL-4R{alpha}, But Not on Eosinophils. J. Immunol. 162: 6178-6183 [Abstract] [Full Text]
Yoneto, T., Yoshimoto, T., Wang, C.-R., Takahama, Y., Tsuji, M., Waki, S., Nariuchi, H. (1999). Gamma Interferon Production Is Critical for Protective Immunity to Infection with Blood-Stage Plasmodium berghei XAT but Neither NO Production nor NK Cell Activation Is Critical. Infect. Immun. 67: 2349-2356 [Abstract] [Full Text]
Ramsingh, A. I., Lee, W. T., Collins, D. N., Armstrong, L. E. (1999). T Cells Contribute to Disease Severity during Coxsackievirus B4 Infection. J. Virol. 73: 3080-3086 [Abstract] [Full Text]
Ohshima, Y., Yang, L-P., Avice, M-N., Kurimoto, M., Nakajima, T., Sergerie, M., Demeure, C. E., Sarfati, M., Delespesse, G. (1999). Naive Human CD4+ T Cells Are a Major Source of Lymphotoxin {alpha}. J. Immunol. 162: 3790-3794 [Abstract] [Full Text]
Brombacher, F., Dorfmuller, A., Magram, J., Dai, W. J., Kohler, G., Wunderlin, A., Palmer-Lehmann, K., Gately, M. K., Alber, G. (1999). IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes. Int Immunol 11: 325-332 [Abstract] [Full Text]
Vos, Q., Snapper, C. M., Mond, J. J. (1999). Heterogeneity in the ability of cytotoxic murine NK cell clones to enhance Ig secretion in vitro. Int Immunol 11: 159-168 [Abstract] [Full Text]
Gramaglia, I., Mauri, D. N., Miner, K. T., Ware, C. F., Croft, M. (1999). Lymphotoxin {alpha}{beta} Is Expressed on Recently Activated Naive and Th1-Like CD4 Cells but Is Down-Regulated by IL-4 During Th2 Differentiation. J. Immunol. 162: 1333-1338 [Abstract] [Full Text]
Zeiler, T., Mantyjarvi, R., Rautiainen, J., Rytkonen-Nissinen, M., Vilja, P., Taivainen, A., Kauppinen, J., Virtanen, T. (1999). T Cell Epitopes of a Lipocalin Allergen Colocalize with the Conserved Regions of the Molecule. J. Immunol. 162: 1415-1422 [Abstract] [Full Text]
Sam, H., Stevenson, M. M. (1999). In Vivo IL-12 Production and IL-12 Receptors {beta}1 and {beta}2 mRNA Expression in the Spleen Are Differentially Up-Regulated in Resistant B6 and Susceptible A/J Mice During Early Blood-Stage Plasmodium chabaudi AS Malaria. J. Immunol. 162: 1582-1589 [Abstract] [Full Text]
Groux, H., Cottrez, F., Rouleau, M., Mauze, S., Antonenko, S., Hurst, S., McNeil, T., Bigler, M., Roncarolo, M.-G., Coffman, R. L. (1999). A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells. J. Immunol. 162: 1723-1729 [Abstract] [Full Text]
Girgis, L., Davis, M. M., de St. Groth, B. F. (1999). The Avidity Spectrum of �T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model. JEM 189: 265-278 [Abstract] [Full Text]
White, D. W., MacNeil, A., Busch, D. H., Pilip, I. M., Pamer, E. G., Harty, J. T. (1999). Perforin-Deficient CD8+ T Cells: In Vivo Priming and Antigen-Specific Immunity Against Listeria monocytogenes. J. Immunol. 162: 980-988 [Abstract] [Full Text]