The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 163, 1319-1324, Copyright © 1986 by Rockefeller University Press

ARTICLES

Enhancement of epidermal regeneration by biosynthetic epidermal growth factor

GL Brown, L Curtsinger 3d, JR Brightwell, DM Ackerman, GR Tobin, HC Polk Jr, C George-Nascimento, P Valenzuela and GS Schultz

Epidermal regeneration depends on mitosis and migration of keratinocytes. Epidermal growth factor is known to stimulate growth of keratinocytes in vitro, thus it might be expected to promote wound healing. The results of this study show that topical application of biosynthetic human epidermal growth factor accelerates epidermal regeneration in split-thickness wounds and partial-thickness burns. The significant enhancement of epidermal regeneration suggests the potential for clinical use of epidermal growth factor for accelerating healing of burns, wounds from trauma, diabetic ulcers, skin graft donor sites, and others.
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