The Journal of Experimental Medicine
Torrey Pines Biolabs
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Journal of Experimental Medicine, Vol 162, 2175-2179, Copyright © 1985 by Rockefeller University Press

ARTICLES

bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia

CR Bartram

Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species. Participation of the c-abl oncogene in this genomic recombination could be ruled out by in situ hybridization studies and Northern blot analysis.
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