Journal of Experimental Medicine, Vol 162, 1387-1392, Copyright © 1985 by Rockefeller University Press

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Multiple class I and class II major histocompatibility complex allospecificities are generated with T cell receptor variable (V) domains created by a single Ti beta V gene family

O Acuto, RE Hussey and EL Reinherz

10 alloreactive cytotoxic T lymphocytes using REX Ti beta variable region (V) gene segments in formation of their antigen/major histocompatibility complex (MHC) T3-Ti receptor were selected, cloned, and characterized in an effort to examine the extent of receptor diversity created by this one V gene family. Multiple and distinct class II as well as class I allospecificities were generated from the formation of different Ti beta V domains. Five allospecificities were directed at various class I epitopes whereas the other five were directed at class II MHC gene products. The following conclusions were drawn: (a) Ti beta V genes do not segregate into those that encode class I and those that encode class II allospecificities; and (b) there is no restriction on the Ti beta V gene pool available to T4+ vs. T8+ T lymphocytes.
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• Li, H., Van Vranken, S., Zhao, Y., Li, Z., Guo, Y., Eisele, L., Li, Y. (2005). Crystal structures of T cell receptor {beta} chains related to rheumatoid arthritis. Protein Sci. 14: 3025-3038 [Abstract] [Full Text]  
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