The Journal of Experimental Medicine
R&D Systems
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Journal of Experimental Medicine, Vol 161, 269-274, Copyright © 1985 by Rockefeller University Press

ARTICLES

T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes

SR Webb, JH Li, I MacNeil, P Marrack, J Sprent and DB Wilson

Previous studies have shown that T cell clones specific for strong Mlsa,d determinants concomitantly display apparently random reactivity to allo-H-2 determinants. One explanation for this finding is that T cell recognition of Mlsa,d and allo-H-2 determinants is controlled by separate sets of receptors. If these receptors were chromosomally unlinked, karyotypically unstable T cell hybrids with dual reactivity for Mlsa,d and particular allo-H-2 determinants would be expected, occasionally, to lose reactivity for one set of determinants, but not the other. The results presented here provide direct support for this prediction.
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