The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 159, 318-323, Copyright © 1984 by Rockefeller University Press

ARTICLES

The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors

D Ramarli, B Parodi, M Fabbi, G Corte and A Lanzavecchia

Human alloreactive proliferating T cell clones have been compared for their capacity to provide help for B cell activation and the generation of a specific cytotoxic response. The results demonstrate that, when triggered by the relevant alloantigen, the same T cell clone can induce a strong polyclonal B cell activation and serve as the only source of helper cells for the generation of a specific cytotoxic response by any source of CTL precursors against any stimulator cell present in culture.
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