Journal of Experimental Medicine, Vol 153, 936-950, Copyright © 1981 by Rockefeller University Press

ARTICLES

Structure of murine Ia antigens. Two dimensional electrophoretic analyses and high pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide

M McMillan, JA Frelinger, PP Jones, DB Murphy, HO McDevitt and L Hood

We demonstrate that an invariant polypeptide, first described by Jones et al. (21), co-immunoprecipitates with our Ia molecules, that its interaction with Ia polypeptides varies with haplotype, and that it is not a precursor of the Aalpha, Abeta, Ealpha, or Ebeta. polypeptides. We also show that the polypeptides that we have previously characterized are contaminated with very little, if any, invariant protein. Further, we have used our high-pressure liquid chromatography tryptic peptide map technique to formally map the genes encoding Aalpha, Abeta, and Ebeta to the I-A subregion using recombinant and F1 hybrid mice.
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• Hood, L., Steinmetz, M., Goodenow, R., Eakle, K., Fisher, D., Kobori, J., Malissen, B., Malissen, M., McMillan, M., McNicholas, J., Orn, A., Pecht, M., Sher, B.T., Smith, L., Stroynowski, I., Sun, H., Winoto, A., Zuniga, M. (1983). Genes of the Major Histocompatibility Complex. Cold Spring Harb Symp Quant Biol 47: 1051-1065 [Abstract]  
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