The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 153, 1021-1026, Copyright © 1981 by Rockefeller University Press

ARTICLES

Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D- isoglutamine, the smallest peptide subunit of bacterial peptidoglycan

YH Chang, CM Pearson and L Chedid

N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), an apparently nonimmunogenic bacterial peptidoglycan-derived small peptide, was found to induce a polyarthritis the rat similar to that induced by Freund's complete adjuvant when injected in the form of an oil emulsion. An oil emulsion of its isomer, N-acetylmuramyl-L-alanyl-L-isoglutamine, which unlike MDP has no immunostimulatory activity, failed to induce the disease.
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