Growth of factor-dependent hemopoietic precursor cell lines

doi:10.1084/jem.152.4.1036

This Article

Full Text (PDF)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Dexter, T. M.

Articles by Metcalf, D.

Search for Related Content

PubMed

PubMed Citation

Articles by Dexter, T. M.

Articles by Metcalf, D.

Pubmed/NCBI databases

Medline Plus Health Information
Substance via MeSH
Stem Cells

Social Bookmarking

What's this?

ARTICLES

Growth of factor-dependent hemopoietic precursor cell lines

TM Dexter, J Garland, D Scott, E Scolnick and D Metcalf

Cell lines have been produced from long-term cultures of mouse bone marrow that require a factor, present in WEHI-3 conditioned medium (CM) or in spleen CM, for their sustained growth. The cell lines were obtained from nonvirus-treated cultures, are nonleukemic, maintain a normal karyotype, and form colonies showing granulocyte maturation when plated in soft agar. Granulocyte/macrophage (GM) colony-stimulating factor is not the inductive moiety involved in the maintenance of proliferation of these cells. It is suggested that the cell lines represent a self-renewing population of cells ancestral to GM colony- forming cells, which may be responding to a hitherto unrecognized regulator.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Schuler, A., Schwieger, M., Engelmann, A., Weber, K., Horn, S., Muller, U., Arnold, M. A., Olson, E. N., Stocking, C. (2008). The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood 111: 4532-4541 [Abstract] [Full Text]
Olsen, S. K., Ota, N., Kishishita, S., Kukimoto-Niino, M., Murayama, K., Uchiyama, H., Toyama, M., Terada, T., Shirouzu, M., Kanagawa, O., Yokoyama, S. (2007). Crystal Structure of the Interleukin-15{middle dot}Interleukin-15 Receptor {alpha} Complex: INSIGHTS INTO TRANS AND CIS PRESENTATION. J. Biol. Chem. 282: 37191-37204 [Abstract] [Full Text]
Tan, P. C., Furness, S. G.B., Merkens, H., Lin, S., McCoy, M. L., Roskelley, C. D., Kast, J., McNagny, K. M. (2006). Na+/H+ Exchanger Regulatory Factor-1 Is a Hematopoietic Ligand for a Subset of the CD34 Family of Stem Cell Surface Proteins. Stem Cells 24: 1150-1161 [Abstract] [Full Text]
Konopleva, M., Shi, Y., Steelman, L. S., Shelton, J. G., Munsell, M., Marini, F., McQueen, T., Contractor, R., McCubrey, J. A., Andreeff, M. (2005). Development of a Conditional In vivo Model to Evaluate the Efficacy of Small Molecule Inhibitors for the Treatment of Raf-Transformed Hematopoietic Cells. Cancer Res. 65: 9962-9970 [Abstract] [Full Text]
Sebollela, A., Cagliari, T. C., Limaverde, G. S. C. S., Chapeaurouge, A., Sorgine, M. H. F., Coelho-Sampaio, T., Ramos, C. H. I., Ferreira, S. T. (2005). Heparin-binding Sites in Granulocyte-Macrophage Colony-stimulating Factor: LOCALIZATION AND REGULATION BY HISTIDINE IONIZATION. J. Biol. Chem. 280: 31949-31956 [Abstract] [Full Text]
Schwegler, C., Dorn-Beineke, A., Nittka, S., Stocking, C., Neumaier, M. (2005). Monoclonal Anti-idiotype Antibody 6G6.C4 Fused to GM-CSF Is Capable of Breaking Tolerance to Carcinoembryonic Antigen (CEA) in CEA-Transgenic Mice. Cancer Res. 65: 1925-1933 [Abstract] [Full Text]
Calfee, M. W., Shelton, J. G., McCubrey, J. A., Pesci, E. C. (2005). Solubility and Bioactivity of the Pseudomonas Quinolone Signal Are Increased by a Pseudomonas aeruginosa-Produced Surfactant. Infect. Immun. 73: 878-882 [Abstract] [Full Text]
Karlsson, R., Engstrom, M., Jonsson, M., Karlberg, P., Pronk, C. J.H., Richter, J., Jonsson, J.-I. (2003). Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes. J. Leukoc. Biol. 74: 923-931 [Abstract] [Full Text]
Kumar, A., Baker, S. J., Lee, C. M., Reddy, E. P. (2003). Molecular Mechanisms Associated with the Regulation of Apoptosis by the Two Alternatively Spliced Products of c-Myb. Mol. Cell. Biol. 23: 6631-6645 [Abstract] [Full Text]
Truong, B.-T. H., Lee, Y.-J., Lodie, T. A., Park, D. J., Perrotti, D., Watanabe, N., Koeffler, H. P., Nakajima, H., Tenen, D. G., Kogan, S. C. (2003). CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood 101: 1141-1148 [Abstract] [Full Text]
Frost, M. J., Ferrao, P. T., Hughes, T. P., Ashman, L. K. (2002). Juxtamembrane Mutant V560GKit Is More Sensitive to Imatinib (STI571) Compared with Wild-Type c-Kit Whereas the Kinase Domain Mutant D816VKit Is Resistant. Molecular Cancer Therapeutics 1: 1115-1124 [Abstract] [Full Text]
Xie, R.-L., van Wijnen, A. J., van der Meijden, C. M., Stein, J. L., Stein, G. S. (2002). Forced Expression of the Interferon Regulatory Factor 2 Oncoprotein Causes Polyploidy and Cell Death in FDC-P1 Myeloid Hematopoietic Progenitor Cells. Cancer Res. 62: 2510-2515 [Abstract] [Full Text]
Chiang, M. Y., Monroe, J. G. (2001). Role for Transcription Pax5A Factor in Maintaining Commitment to the B Cell Lineage by Selective Inhibition of Granulocyte-Macrophage Colony-Stimulating Factor Receptor Expression. J. Immunol. 166: 6091-6098 [Abstract] [Full Text]
Sun, X., Layton, J. E., Elefanty, A., Lieschke, G. J. (2001). Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL-expressing cells, demonstrating synergy between AG490 and STI571. Blood 97: 2008-2015 [Abstract] [Full Text]
Lee, A. W.-M., States, D. J. (2000). Both Src-Dependent and -Independent Mechanisms Mediate Phosphatidylinositol 3-Kinase Regulation of Colony-Stimulating Factor 1-Activated Mitogen-Activated Protein Kinases in Myeloid Progenitors. Mol. Cell. Biol. 20: 6779-6798 [Abstract] [Full Text]
Reuss, F. U., Coffin, J. M. (2000). The Mouse Mammary Tumor Virus Transcription Enhancers for Hematopoietic Progenitor and Mammary Gland Cells Share Functional Elements. J. Virol. 74: 8183-8187 [Abstract] [Full Text]
Wang, A., Braun, S. E., Sonpavde, G., Cornetta, K. (2000). Antileukemic Activity of Flt3 Ligand in Murine Leukemia. Cancer Res. 60: 1895-1900 [Abstract] [Full Text]
Fujio, K., Nosaka, T., Kojima, T., Kawashima, T., Yahata, T., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Yamamoto, K., Nishimura, T., Kitamura, T. (2000). Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain. Blood 95: 2204-2210 [Abstract] [Full Text]
Graner, M., Raymond, A., Romney, D., He, L., Whitesell, L., Katsanis, E. (2000). Immunoprotective Activities of Multiple Chaperone Proteins Isolated from Murine B-Cell Leukemia/Lymphoma. Clin. Cancer Res. 6: 909-915 [Abstract] [Full Text]
Kogan, S. C., Hong, S.-h., Shultz, D. B., Privalsky, M. L., Bishop, J. M. (2000). Leukemia initiated by PMLRARalpha : the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable. Blood 95: 1541-1550 [Abstract] [Full Text]
Delassus, S., Titley, I., Enver, T. (1999). Functional and Molecular Analysis of Hematopoietic Progenitors Derived From the Aorta-Gonad-Mesonephros Region of the Mouse Embryo. Blood 94: 1495-1503 [Abstract] [Full Text]
Jenkins, B. J., Le, F., Gonda, T. J. (1999). A Cell Type-specific Constitutive Point Mutant of the Common beta -Subunit of the Human Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Interleukin (IL)-3, and IL-5 Receptors Requires the GM-CSF Receptor alpha -Subunit for Activation. J. Biol. Chem. 274: 8669-8677 [Abstract] [Full Text]
Watowich, S. S., Liu, K. D., Xie, X., Lai, S. Y., Mikami, A., Longmore, G. D., Goldsmith, M. A. (1999). Oligomerization and Scaffolding Functions of the Erythropoietin Receptor Cytoplasmic Tail. J. Biol. Chem. 274: 5415-5421 [Abstract] [Full Text]
Weiler, S. R., Gooya, J. M., Ortiz, M., Tsai, S., Collins, S. J., Keller, J. R. (1999). D3: A Gene Induced During Myeloid Cell Differentiation of Linlo c-Kit+ Sca-1+ Progenitor Cells. Blood 93: 527-536 [Abstract] [Full Text]
Lee, A. W.-m. (1999). Synergistic Activation of Mitogen-Activated Protein Kinase by Cyclic AMP and Myeloid Growth Factors Opposes Cyclic AMP's Growth-Inhibitory Effects. Blood 93: 537-553 [Abstract] [Full Text]
Borghesi, L. A., Yamashita, Y., Kincade, P. W. (1999). Heparan Sulfate Proteoglycans Mediate Interleukin-7- Dependent B Lymphopoiesis. Blood 93: 140-148 [Abstract] [Full Text]
Zhou, P., Qian, L., Bieszczad, C. K., Noelle, R., Binder, M., Levy, N. B., Craig, R. W. (1998). Mcl-1 in Transgenic Mice Promotes Survival in a Spectrum of Hematopoietic Cell Types and Immortalization in the Myeloid Lineage. Blood 92: 3226-3239 [Abstract] [Full Text]
Verdier, F., Chretien, S., Muller, O., Varlet, P., Yoshimura, A., Gisselbrecht, S., Lacombe, C., Mayeux, P. (1998). Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5�(STAT5) Activation. POSSIBLE INVOLVEMENT OF THE UBIQUITINATED CIS PROTEIN. J. Biol. Chem. 273: 28185-28190 [Abstract] [Full Text]
Jenkins, B. J., Blake, T. J., Gonda, T. J. (1998). Saturation Mutagenesis of the beta �Subunit of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor Shows Clustering of Constitutive Mutations, Activation of ERK MAP Kinase and STAT Pathways, and Differential beta �Subunit Tyrosine Phosphorylation. Blood 92: 1989-2002 [Abstract] [Full Text]
Meyer, J., Jucker, M., Ostertag, W., Stocking, C. (1998). Carboxyl-Truncated STAT5beta Is Generated by a Nucleus-Associated Serine Protease in Early Hematopoietic Progenitors. Blood 91: 1901-1908 [Abstract] [Full Text]
Hu, M. C.-T., Chien, S. L. (1998). The Cytoplasmic Domain of Stem Cell Antigen CD34 Is Essential for Cytoadhesion Signaling But Not Sufficient for Proliferation Signaling. Blood 91: 1152-1162 [Abstract] [Full Text]
von Laer, D., Thomsen, S., Vogt, B., Donath, M., Kruppa, J., Rein, A., Ostertag, W., Stocking, C. (1998). Entry of Amphotropic and 10A1 Pseudotyped Murine Retroviruses Is Restricted in Hematopoietic Stem Cell Lines. J. Virol. 72: 1424-1430 [Abstract] [Full Text]
Hayashi, R. J., Loh, D. Y., Kanagawa, O., Wang, F. (1998). Differences Between Responses of Naive and Activated T Cells to Anergy Induction. J. Immunol. 160: 33-38 [Abstract] [Full Text]
Joneja, B., Chen, H.-C., Seshasayee, D., Wrentmore, A. L., Wojchowski, D. M. (1997). Mechanisms of Stem Cell Factor and Erythropoietin Proliferative Co-signaling in FDC2-ER Cells. Blood 90: 3533-3545 [Abstract] [Full Text]
Verdier, F., Chretien, S., Billat, C., Gisselbrecht, S., Lacombe, C., Mayeux, P. (1997). Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2. AN ALTERNATE PATHWAY FOR ERYTHROPOIETIN-INDUCED PHOSPHATIDYLINOSITOL 3-KINASE ACTIVATION. J. Biol. Chem. 272: 26173-26178 [Abstract] [Full Text]
Yoshikawa, H., Sakihama, T., Nakajima, Y., Tasaka, K. (1997). Fcgamma RIII-Mediated Regulation of Hematopoiesis in Murine Bone Marrow Cells by Interleukin-3 and CD95 (Fas/Apo-1). Blood 90: 1911-1919 [Abstract] [Full Text]
Cooper, C. L., Brady, G., Bilia, F., Iscove, N. N., Quesenberry, P. J. (1997). Expression of the Id Family Helix-Loop-Helix Regulators During Growth and Development in the Hematopoietic System. Blood 89: 3155-3165 [Abstract] [Full Text]
Miyakawa, Y., Oda, A., Druker, B. J., Ozaki, K., Handa, M., Ohashi, H., Ikeda, Y. (1997). Thrombopoietin and Thrombin Induce Tyrosine Phosphorylation of Vav in Human Blood Platelets. Blood 89: 2789-2798 [Abstract] [Full Text]
Musashi, M., Sakurada, K., Kawamura, K.-I., Iwasaki, H., Tsuda, Y., Kobayashi, M., Sasaki, M., Kato, K., Tanaka, E., Sudo, T., Asaka, M., Miyazaki, T. (1997). Phorbol Ester Enhancement of IL-3-Dependent Proliferation of Primitive Hematopoietic Progenitors of Mice in Culture. J. Pharmacol. Exp. Ther. 280: 225-231 [Abstract] [Full Text]
Russ, A.�P., Friedel, C., Ballas, K., Kalina, U., Zahn, D., Strebhardt, K., von�Melchner, H. (1996). Identification of genes induced by factor deprivation in hematopoietic cells undergoing apoptosis using gene-trap mutagenesis and site-specific�recombination. Proc. Natl. Acad. Sci. USA 93: 15279-15284 [Abstract] [Full Text]
Ilaria, R. L. Jr., Van Etten, R. A. (1996). P210 and P190BCR/ABL Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members. J. Biol. Chem. 271: 31704-31710 [Abstract] [Full Text]
Jenkins, B. J., Bagley, C. J., Woodcock, J., Lopez, A. F., Gonda, T. J. (1996). Interacting Residues in the Extracellular Region of the Common beta Subunit of the Human Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptors Involved in Constitutive Activation. J. Biol. Chem. 271: 29707-29714 [Abstract] [Full Text]
Takahashi, T., Tanaka, M., Ogasawara, J., Suda, T., Murakami, H., Nagata, S. (1996). Swapping between Fas and Granulocyte Colony-stimulating Factor Receptor. J. Biol. Chem. 271: 17555-17560 [Abstract] [Full Text]
Jiang, N., He, T.-C., Miyajima, A., Wojchowski, D. M. (1996). The box1 Domain of the Erythropoietin Receptor Specifies Janus Kinase 2Activation and Functions Mitogenically within an Interleukin 2beta -Receptor Chimera. J. Biol. Chem. 271: 16472-16476 [Abstract] [Full Text]
Middleton, S. A., Johnson, D. L., Jin, R., McMahon, F. J., Collins, A., Tullai, J., Gruninger, R. H., Jolliffe, L. K., Mulcahy, L. S. (1996). Identification of a Critical Ligand Binding Determinant of the Human Erythropoietin Receptor. EVIDENCE FOR COMMON LIGAND BINDING MOTIFS IN THE CYTOKINE RECEPTOR FAMILY. J. Biol. Chem. 271: 14045-14054 [Abstract] [Full Text]
Nagata, Y., Nagahisa, H., Aida, Y., Okutomi, K., Nagasawa, T., Todokoro, K. (1995). Thrombopoietin Induces Megakaryocyte Differentiation in Hematopoietic Progenitor FDC-P2 Cells. J. Biol. Chem. 270: 19673-19675 [Abstract] [Full Text]
B�nsch, D., Kammer, W., Lischke, A., Friedrich, K. (1995). Species-specific Agonist/Antagonist Activities of Human Interleukin-4 Variants Suggest Distinct Ligand Binding Properties of Human and Murine Common Receptor [IMAGE] Chain. J. Biol. Chem. 270: 8452-8457 [Abstract] [Full Text]
Dranoff, G, Crawford, A., Sadelain, M, Ream, B, Rashid, A, Bronson, R., Dickersin, G., Bachurski, C., Mark, E., Whitsett, J., et, al. (1994). Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 264: 713-716 [Abstract]
Wang, L., Myers, M. Jr, Sun, X., Aaronson, S., White, M, Pierce, J. (1993). IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. Science 261: 1591-1594 [Abstract]
Alvarez-Silva, M, da Silva, L., Borojevic, R (1993). Cell membrane-associated proteoglycans mediate extramedullar myeloid proliferation in granulomatous inflammatory reactions to schistosome eggs. J. Cell Sci. 104: 477-484 [Abstract]
Wong, P M, Chung, S W, Nienhuis, A W (1987). Retroviral transfer and expression of the interleukin-3 gene in hemopoietic cells.. Genes Dev. 1: 358-365 [Abstract]
Birchenall-Sparks, M., Farrar, W., Rennick, D, Kilian, P., Ruscetti, F. (1986). Regulation of expression of the interleukin-2 receptor on hematopoietic cells by interleukin-3. Science 233: 455-458 [Abstract]
Gaines, P., Geiger, J. N., Knudsen, G., Seshasayee, D., Wojchowski, D. M. (2000). GATA-1- and FOG-dependent Activation of Megakaryocytic alpha IIB Gene Expression. J. Biol. Chem. 275: 34114-34121 [Abstract] [Full Text]
Arnold, R., Liou, J., Drexler, H. C. A., Weiss, A., Kiefer, F. (2001). Caspase-mediated Cleavage of Hematopoietic Progenitor Kinase 1 (HPK1) Converts an Activator of NFkappa B into an Inhibitor of NFkappa B. J. Biol. Chem. 276: 14675-14684 [Abstract] [Full Text]
Parada, Y., Banerji, L., Glassford, J., Lea, N. C., Collado, M., Rivas, C., Lewis, J. L., Gordon, M. Y., Thomas, N. S. B., Lam, E. W.-F. (2001). BCR-ABL and Interleukin 3 Promote Haematopoietic Cell Proliferation and Survival through Modulation of Cyclin D2 and p27Kip1 Expression. J. Biol. Chem. 276: 23572-23580 [Abstract] [Full Text]