The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 146, 600-605, Copyright © 1977 by Rockefeller University Press

ARTICLES

Cytotoxic T cells distinguish between trinitrophenyl- and dinitrophenyl- modified syngeneic cells

J Forman

Spleen cells sensitized against trinitrophenyl (TNP)-modified stimulator cells displayed a cytotoxic effect against syngeneic TNP- modified but not dinitrophenyl (DNP)-modified target cells. The same finding was observed in the opposite direction; that is, effector cells sensitized against DNP-modified stimulator cells did not cross kill TNP- modified targets. The specificity of the anti-TNP effector cells was confirmed in a cold target competition assay. Presensitization in vivo with hapten-modified cells followed by rechallenge and testing in vitro did not alter the specificity of the response between the haptens. These data indicate that the receptor(s) on the cytotoxic T cell can distinguish between two closely related haptenic molecules.
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