The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 600-617, Copyright © 1971 by The Rockefeller University Press

ARTICLE

CAPSULATION OF PNEUMOCOCCUS WITH SOLUBLE CELL WALL-LIKE POLYSACCHARIDE : II. NONIDENTITY OF CELL WALL AND SOLUBLE CELL WALL-LIKE POLYSACCHARIDES DERIVED FROM THE SAME AND FROM DIFFERENT PNEUMOCOCCAL STRAINS



Gerald Schiffman Ph.D.1, Donald L. Bornstein M.D.1, and Robert Austrian M.D.1

1 From the John Herr Musser Department of Research Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Methods are described for the separation of the C or cell wall polysaccharide from the Cs or soluble C-like capsular polysaccharide of Cs pneumococcal strains. Immunologic analysis has shown that both the C and Cs polysaccharides of a variety of pneumococcal strains are heterogeneous and that the dissimilarities appear to reside in the mucopeptide portion of the molecule or in the region of its attachment to the teichoic acid moiety of the molecule rather than in the teichoic acid fraction. Differences of the type described have been observed in the C polysaccharides of wild-type capsulated strains of several types, in those of independently isolated noncapsulated variants derived from a single strain of a given capsular type, and in the C and Cs polysaccharides of spontaneous mutant or transformed strains of pneumococci producing capsules of Cs polysaccharide.

Submitted on May 21, 1971


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