The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 127, 853-866, Copyright © 1968 by The Rockefeller University Press

ARTICLE

INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM

Roger Foster Jr. M.D.1, Donald Metcalf M.D.1, and Rosemary Kirchmyer 1

1 From the Roswell Park Memorial Institute, Buffalo, New York 14203

1. Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally into normal ICR/Ha Swiss mice. Colony-stimulating activity was assayed in vitro by the stimulation of hemopoietic colony formation by DBA/1 bone marrow cells.

2. The inducing agent in leukemic serum was passageable, filterable, sedimentable, and heat-, ether-, and UV-labile.

3. A similar agent was recovered from normal Swiss serum after blind serial passages through normal mice.

4. LDH elevating virus induced a similar elevation of serum colony-stimulating activity when injected at high titers, and cross-resistance was demonstrated between LDH virus and the passaged leukemic serum agent.

 Submitted on September 5, 1967


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