The Journal of Experimental Medicine, Vol 127, 411-429,
Copyright © 1968 by The Rockefeller University Press
MECHANISMS OF ACTIVATION OF C'1 ESTERASE IN HEREDITARY ANGIONEUROTIC EDEMA PLASMA IN VITRO
:
THE ROLE OF HAGEMAN FACTOR, A CLOT-PROMOTING AGENT
Virginia H. Donaldson M.D.1
1 From the Laboratories of The Research Division, St. Vincent Charity Hospital, Cleveland, Ohio 44115
The generation of C'1 esterase activity in siliconed plasma obtained from individuals with hereditary angioneurotic edema in remission tends to occur spontaneously, but can be hastened during its incubation with preparations of activated Hageman factor. This effect of activated Hageman factor could not be shown during its incubation with normal siliconed plasma, nor could consumption of normal serum inhibition of C'1 esterase be clearly shown.
Soy bean trypsin inhibitor and heparin could impair this enhanced generation of C'1 esterase but neither inhibits the esterolytic function of C'1 esterase once formed. Trasylol was less effective in blocking this effect of activated Hageman factor.
While the mechanism of the effect of activated Hageman factor upon C'1 activation remains obscure, it is apparent that some intermediate steps, possibly involving a kinin-forming system of plasma, may play a role.
Submitted on August 15, 1967
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