The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 122, 195-205, Copyright © 1965 by The Rockefeller Institute

ARTICLE

DETECTION OF STREPTOCOCCAL GROUP-SPECIFIC ANTIBODIES IN HUMAN SERA

Walter W. Karakawa Ph.D.1, C. Kirk Osterland M.D.1, and Richard Krause M.D.1

1 From the Department of Preventive Medicine, Washington University School of Medicine, St. Louis

Two serologically distinct antibodies directed against different antigenic sites on the Group A carbohydrate were detected in human sera by agglutination techniques. Agglutinins with A-variant specificity were demonstrable by the direct agglutination of purified A-variant cell walls, whereas indirect Coombs-type agglutinins with Group A specificity were demonstrable with Group A cell walls. Selective adsorption with homologous cell walls as well as inhibition studies with the soluble carbohydrates confirmed the specificity of the two types of agglutinins.

There was an obvious correlation between the magnitude of the antistreptolysin O titer, and the direct Group A-variant and the indirect Group titers. These data suggest that indirect anti-Group A agglutinins and direct anti-Group A-variant agglutinins are produced following a Group A streptococcal infection.

 Submitted on March 22, 1965


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