The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 119, 151-166, Copyright © 1964, by The Rockefeller Institute

ARTICLE

SEROLOGIC DEMONSTRATION OF DUAL SPECIFICITY OF RABBIT BIVALENT HYBRID ANTIBODY

H. H. Fudenberg M.D.1, Genevieve Drews M.D.1, and A. Nisonoff Ph.D.1

1 From the Department of Medicine, University of California School of Medicine, San Francisco, and the Department of Microbiology, University of Illinois, Urbana

Hybrid, bivalent antibody molecules bearing specific combining sites for both ovalbumin and bovine gamma globulin were produced by reoxidation of a mixture of the 3.5S fragments of the two specifically purified antibodies. The dual specificity and the properties of the hybrid antibody were demonstrated by mixed agglutination and two stage agglutination experiments, and by test systems utilizing inhibition of agglutination or dispersal of agglutinates followed by antiglobulin reactions.

Submitted on September 4, 1963


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