STUDIES ON ARTIFICIAL ANTIGENS: III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS

doi:10.1084/jem.118.6.953

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ARTICLE

STUDIES ON ARTIFICIAL ANTIGENS : III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS

Bernard B. Levine M.D.¹, Antonio Ojeda M.D.¹, and Baruj Benacerraf M.D.¹

¹ From the Departments of Medicine and Pathology, New York University School of Medicine, New York

The genetic transmission of the capacity to develop an immuneresponse to hapten-polylysine conjugates was studied in guineapigs.

82 per cent of the 22 offspring of 8 pairs of responder(guinea pigs which are capable of an immune response) parentswere also responders, whereas, none of the 26 offspring of 9pairs of non-responder parents were responders.

None of 11 strain13 guinea pigs and 100 per cent of 40 strain 2 guinea pigs wereresponders.

These findings are consistent with the view thatthe capacity to respond immunologically to hapten-polylysineconjugates is genetically transmitted as a unigenic Mendeliandominant.

Submitted on July 29, 1963

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