The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 118, 1021-1035, Copyright © 1963, by The Rockefeller Institute

ARTICLE

IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS : A SEARCH FOR ANTIBODY-ABSORBING DEPOTS OF ALLERGEN



Jack R. Battisto Ph.D.1 and Merrill W. Chase Ph.D.1

1 From the Albert Einstein College of Medicine of Yeshiva University and The Rockefeller Institute, New York

Guinea pigs fed picryl chloride to induce specific immunologic unresponsiveness cleared small amounts of venously infused antipicryl antibody at a rate equal to that of normal guinea pigs.

Catabolism of passively administered picryl-specific antibody did not alter the unresponsive state of picryl chloride-fed guinea pigs or the responsive state of normal guinea pigs.

Lymphoid cells of picryl chloride immunized guinea pigs produced equal amounts of picryl-specific antibody in picryl chloride-fed and normal animals.

Allergen-fed guinea pigs remained unresponsive to attempted sensitization with the allergen in excess of 10 months after the final feeding, though some became feebly sensitive between 9 and 11 months. Second attempts to make unresponsive animals hypersensitive were unsuccessful.

White blood cells of guinea pigs unresponsive to picryl chloride were unable to transfer delayed-type hypersensitivity for picryl chloride to normal recipients yet readily transferred tuberculin hypersensitivity.

 Submitted on August 15, 1963


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