The Journal of Experimental Medicine, Vol 118, 635-648,
Copyright © 1963, by The Rockefeller Institute
HOMOLOGOUS DISEASE IN THE ADULT RAT, A MODEL FOR AUTOIMMUNE DISEASE
:
I. GENERAL FEATURES AND CUTANEOUS LESIONS
Peter Stastny M.D.1,
Vernie A. Stembridge M.D.1, and
Morris Ziff M.D.1
1 From the Department of Internal Medicine, Rheumatic Diseases Unit, and the Department of Pathology, The University of Texas Southwestern Medical School, Dallas
The cutaneous lesions of adult rats with homologous disease are described, and evidence is presented to indicate that they have an immunologic basis. The skin changes included erythema, purpura, edema, and a variety of inflammatory lesions. In the more active lesions, dermal infiltration, hydropic degeneration, acanthosis, and atrophy of the epidermis with hyperkeratosis and follicular plugging were present. In some cases, ulceration and sloughing were also observed. More chronic lesions were characterized by atrophy of the epidermis and collagenization of the dermis with disappearance of the skin appendages.
Rejection of autografts was observed simultaneously with acceptance of homografts. The histologic appearance of autografts undergoing rejection was similar to that of the spontaneous skin lesions, suggesting that the latter, too, had an immunologic basis. In favor of this, also, was the specificity of the dermatitis for the skin of the host, with sparing of neighboring homograft tissue.
There was a histologic similarity between the spontaneous skin lesions of homologous disease and those of lupus erythematosus on the one hand, and scleroderma on the other, thus supporting the possibility that the cutaneous lesions of these connective tissue diseases of man may also have an immunologic basis.
It was concluded that the adult rat with homologous disease may furnish a model for human autoimmune disease.
Submitted on April 30, 1963
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