The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 118, 315-326, Copyright © 1963, by The Rockefeller Institute

ARTICLE

PLASMA PROTEIN FORMATION IN VITRO BY TISSUES FROM MICE INFECTED WITH STAPHYLOCOCCI

Curtis A. Williams Jr. PhD.1, Richard Asofsky M.D.1, and G. Jeanette Thorbecke M.D.1

1 From The Rockefeller Institute and New York University Medical Center, New York

Isotopic labeling of plasma proteins in vitro by tissues from staphylococcal-infected and control mice was examined, using autoradiography of immunoelectrophoretic patterns. The results indicate that in infected animals there is hyperactivity of liver tissue in producing albumin, alpha- and ß-globulins, and of spleen tissue in producing immune globulins. The observed increase in labeling of some proteins by tissues from infected mice is to a large extent correlated with an increase of these proteins in the serum.

Submitted on April 11, 1963


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