The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 118, 73-98, Copyright © 1963, by The Rockefeller Institute

ARTICLE

THE PURIFICATION AND PARTIAL CHARACTERIZATION OF SEVERAL FORMS OF HOG RENIN SUBSTRATE

Leonard T. Skeggs Jr. Ph.D.1, Kenneth E. Lentz Ph.D.1, Harry Hochstrasser Ph.D.1, and Joseph R. Kahn M.D.1

1 From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

Hog renin substrate has been separated into three major (A, B, and C) and two minor forms (D and E) by DEAE cellulose chromatography. Two of the major forms (B and C) have been further fractionated into two additional types (1 and 2) by countercurrent distribution.

The purification of substrates A, C1, and C2 has been completed. Analysis shows that all three are glycoproteins with molecular weights of about 57,000, and have similar amino acid compositions. Differences exist in the sialic acid, glucosamine, and neutral hexose content, which may account for different physical properties.

All the forms of the substrates are attacked by renin at similar rates, and appear to yield the same angiotensin I.

 Submitted on April 4, 1963


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